tokens: The most common side effects are infection , suppression of the bone marrow ( decreasing numbers of leukocytes , erythrocytes , and thrombocytes ) , headache , hemorrhage ( bleeding ) , pleural effusion ( fluid around the lungs ) , dyspnea ( difficulty breathing ) , diarrhea , vomiting , nausea ( feeling sick ) , abdominal pain ( belly ache ) , skin rash , musculoskeletal pain , tiredness , swelling in the legs and arms and in the face , fever .