tokens: CEEs are specifically approved in countries such as the United States and Canada for the treatment of moderate to severe vasomotor symptoms ( hot flashes ) and vulvovaginal atrophy ( atrophic vaginitis , atrophic urethritis ) associated with menopause , hypoestrogenism due to hypogonadism , ovariectomy , or primary ovarian failure , abnormal uterine bleeding , the palliative treatment of metastatic breast cancer in women , the palliative treatment of advanced androgen-dependent prostate cancer in men , and the prevention of postmenopausal osteoporosis .