I want to test the ability of students to read a passage and answer questions about it. Could you please come up with a good question for the passage "The teachings on the Four Noble Truths are regarded as central to the teachings of Buddhism, and are said to provide a conceptual framework for Buddhist thought. These four truths explain the nature of dukkha (suffering, anxiety, unsatisfactoriness), its causes, and how it can be overcome. The four truths are:[note 4]"? 

Who might try to understand the nature of dukkha?