sentence: Macrophages are responsible for protecting tissues from foreign substances.
sentences_before: Monocytes which migrate from the bloodstream to the tissues will then differentiate into macrophages or dendritic cells, which then stay in the tissue.
sentences_after: They are cells that possess a large smooth nucleus, a large area of cytoplasm and many internal vesicles for processing foreign material.
concept_name: macrophage
headings: Monocyte Physiology
categories: Immunology Blood cells