payload: {"action":"created","issue":{"url":"https://api.github.com/repos/phargarten2/miWQS/issues/2","repository_url":"https://api.github.com/repos/phargarten2/miWQS","labels_url":"https://api.github.com/repos/phargarten2/miWQS/issues/2/labels{/name}","comments_url":"https://api.github.com/repos/phargarten2/miWQS/issues/2/comments","events_url":"https://api.github.com/repos/phargarten2/miWQS/issues/2/events","html_url":"https://github.com/phargarten2/miWQS/issues/2","id":446654521,"node_id":"MDU6SXNzdWU0NDY2NTQ1MjE=","number":2,"title":"Poisson WQS Regression Unstable Indices and Rsolnp issues","user":{"login":"phargarten2","id":17706062,"node_id":"MDQ6VXNlcjE3NzA2MDYy","avatar_url":"https://avatars3.githubusercontent.com/u/17706062?v=4","gravatar_id":"","url":"https://api.github.com/users/phargarten2","html_url":"https://github.com/phargarten2","followers_url":"https://api.github.com/users/phargarten2/followers","following_url":"https://api.github.com/users/phargarten2/following{/other_user}","gists_url":"https://api.github.com/users/phargarten2/gists{/gist_id}","starred_url":"https://api.github.com/users/phargarten2/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/phargarten2/subscriptions","organizations_url":"https://api.github.com/users/phargarten2/orgs","repos_url":"https://api.github.com/users/phargarten2/repos","events_url":"https://api.github.com/users/phargarten2/events{/privacy}","received_events_url":"https://api.github.com/users/phargarten2/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":{"login":"phargarten2","id":17706062,"node_id":"MDQ6VXNlcjE3NzA2MDYy","avatar_url":"https://avatars3.githubusercontent.com/u/17706062?v=4","gravatar_id":"","url":"https://api.github.com/users/phargarten2","html_url":"https://github.com/phargarten2","followers_url":"https://api.github.com/users/phargarten2/followers","following_url":"https://api.github.com/users/phargarten2/following{/other_user}","gists_url":"https://api.github.com/users/phargarten2/gists{/gist_id}","starred_url":"https://api.github.com/users/phargarten2/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/phargarten2/subscriptions","organizations_url":"https://api.github.com/users/phargarten2/orgs","repos_url":"https://api.github.com/users/phargarten2/repos","events_url":"https://api.github.com/users/phargarten2/events{/privacy}","received_events_url":"https://api.github.com/users/phargarten2/received_events","type":"User","site_admin":false},"assignees":[{"login":"phargarten2","id":17706062,"node_id":"MDQ6VXNlcjE3NzA2MDYy","avatar_url":"https://avatars3.githubusercontent.com/u/17706062?v=4","gravatar_id":"","url":"https://api.github.com/users/phargarten2","html_url":"https://github.com/phargarten2","followers_url":"https://api.github.com/users/phargarten2/followers","following_url":"https://api.github.com/users/phargarten2/following{/other_user}","gists_url":"https://api.github.com/users/phargarten2/gists{/gist_id}","starred_url":"https://api.github.com/users/phargarten2/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/phargarten2/subscriptions","organizations_url":"https://api.github.com/users/phargarten2/orgs","repos_url":"https://api.github.com/users/phargarten2/repos","events_url":"https://api.github.com/users/phargarten2/events{/privacy}","received_events_url":"https://api.github.com/users/phargarten2/received_events","type":"User","site_admin":false}],"milestone":null,"comments":7,"created_at":"2019-05-21T14:32:31Z","updated_at":"2019-06-18T18:17:14Z","closed_at":null,"author_association":"OWNER","body":" From: Ariane Guilbert, Université de Bordeaux\r\n Date:  May 10, 2019, 11:40 AM\r\n\r\nDear Mr. Hargarten,\r\n\r\nI use your **miWQS**  package and its `estimate.wqs()` function to study the relationships between several endocrine disruptors and child neurodevelopment (test score). Based on the distribution of my dependent variable, I apply the family option “Poisson” (as an approximation of the negative binomial distribution).\r\n However, I face some problems. If I run several times the `estimate.wqs()` function:\r\n\r\n- I get wqs index values very unstable, sometimes highly significant, sometimes not (I did not set a seed to check the stability of the results);\r\n\r\n- I frequently get the following error message which aborts the calculations \r\n```\r\nError in if (mac(tol + tt[1], tt[2] - tt[3])) <= 0) { :\r\n     missing value where TRUE/FALSE needed.\r\n``` \r\n\r\nWhat might be the reasons for such issues: the approximation of the negative binomial distribution of the outcome by a Poisson distribution?  Exposure variables weakly related to the outcome? Exposure variables having opposite effects on the outcome (while beta1 is expected to be either positive or negative)?   \r\n\r\nI thank you very much for your answer and for having developed this tool."},"comment":{"url":"https://api.github.com/repos/phargarten2/miWQS/issues/comments/503252044","html_url":"https://github.com/phargarten2/miWQS/issues/2#issuecomment-503252044","issue_url":"https://api.github.com/repos/phargarten2/miWQS/issues/2","id":503252044,"node_id":"MDEyOklzc3VlQ29tbWVudDUwMzI1MjA0NA==","user":{"login":"ArianeGui","id":50911919,"node_id":"MDQ6VXNlcjUwOTExOTE5","avatar_url":"https://avatars0.githubusercontent.com/u/50911919?v=4","gravatar_id":"","url":"https://api.github.com/users/ArianeGui","html_url":"https://github.com/ArianeGui","followers_url":"https://api.github.com/users/ArianeGui/followers","following_url":"https://api.github.com/users/ArianeGui/following{/other_user}","gists_url":"https://api.github.com/users/ArianeGui/gists{/gist_id}","starred_url":"https://api.github.com/users/ArianeGui/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ArianeGui/subscriptions","organizations_url":"https://api.github.com/users/ArianeGui/orgs","repos_url":"https://api.github.com/users/ArianeGui/repos","events_url":"https://api.github.com/users/ArianeGui/events{/privacy}","received_events_url":"https://api.github.com/users/ArianeGui/received_events","type":"User","site_admin":false},"created_at":"2019-06-18T18:17:14Z","updated_at":"2019-06-18T18:17:14Z","author_association":"NONE","body":"> When setting b1.pos = FALSE, did you find a positive WQS beta index in the training set or in the validation set?\r\n\r\nI mean the final WQS beta index you get after running the estimate.wqs() function. \r\n\r\n> Also, have you heard back about the Rsolnp issue or did you no longer need to since you avoided the error by taking several steps as described above?\r\nI sent an email to the author of the function but did not get a feedback. I should contact him again. \r\n\r\nThank you for your reply. \r\n\r\nAriane Guilbert. "}}
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