payload: {"action":"opened","issue":{"url":"https://api.github.com/repos/Open-Systems-Pharmacology/OSPSuite.Core/issues/652","repository_url":"https://api.github.com/repos/Open-Systems-Pharmacology/OSPSuite.Core","labels_url":"https://api.github.com/repos/Open-Systems-Pharmacology/OSPSuite.Core/issues/652/labels{/name}","comments_url":"https://api.github.com/repos/Open-Systems-Pharmacology/OSPSuite.Core/issues/652/comments","events_url":"https://api.github.com/repos/Open-Systems-Pharmacology/OSPSuite.Core/issues/652/events","html_url":"https://github.com/Open-Systems-Pharmacology/OSPSuite.Core/issues/652","id":508493959,"node_id":"MDU6SXNzdWU1MDg0OTM5NTk=","number":652,"title":"Cannot calculate sensitivity after PI","user":{"login":"Yuri05","id":25061876,"node_id":"MDQ6VXNlcjI1MDYxODc2","avatar_url":"https://avatars2.githubusercontent.com/u/25061876?v=4","gravatar_id":"","url":"https://api.github.com/users/Yuri05","html_url":"https://github.com/Yuri05","followers_url":"https://api.github.com/users/Yuri05/followers","following_url":"https://api.github.com/users/Yuri05/following{/other_user}","gists_url":"https://api.github.com/users/Yuri05/gists{/gist_id}","starred_url":"https://api.github.com/users/Yuri05/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/Yuri05/subscriptions","organizations_url":"https://api.github.com/users/Yuri05/orgs","repos_url":"https://api.github.com/users/Yuri05/repos","events_url":"https://api.github.com/users/Yuri05/events{/privacy}","received_events_url":"https://api.github.com/users/Yuri05/received_events","type":"User","site_admin":false},"labels":[{"id":562220032,"node_id":"MDU6TGFiZWw1NjIyMjAwMzI=","url":"https://api.github.com/repos/Open-Systems-Pharmacology/OSPSuite.Core/labels/type:%20bug","name":"type: bug","color":"fbca04","default":false}],"state":"open","locked":false,"assignee":null,"assignees":[],"milestone":null,"comments":0,"created_at":"2019-10-17T13:55:58Z","updated_at":"2019-10-17T13:55:58Z","closed_at":null,"author_association":"MEMBER","body":"\r\n[19_15.zip](https://github.com/Open-Systems-Pharmacology/OSPSuite.Core/files/3739647/19_15.zip)\r\n\r\nWhen the PI in the project attached is started: the PI itself is finished immediately. However calculation of sensitivity never ends. Probably a numerical issue.\r\n![grafik](https://user-images.githubusercontent.com/25061876/67014751-a789f200-f0f5-11e9-8650-db41f417c08d.png)\r\n\r\n\r\nInterestingly: one of the identification parameters is biliary plasma clearance. In the original simulation it is set to 0. In the PI it is set to fixed with initial value 0 (thus it has no effect on optimization results). But if Bil_PLS is removed from the list of identification parameters: sensitivity can be calculated.\r\n\r\n![grafik](https://user-images.githubusercontent.com/25061876/67015194-72ca6a80-f0f6-11e9-84ba-eea888808ae4.png)\r\n"}}
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