The following are multiple choice questions (with answers) about medical knowledge.   **Question:** A 46-year-old man comes to the emergency department because of a 4-week history of fatigue and headache that have gotten progressively worse. He has allergic asthma treated with inhaled salbutamol. He immigrated to the USA from Thailand 9 years ago. He lives by himself and works as a waiter in a restaurant. He has had 6 lifetime male sexual partners and uses condoms inconsistently. He drinks 1–2 beers daily. His temperature is 38.2°C (100.8°F), pulse is 88/min, and blood pressure is 128/76 mm Hg. Examination of the mouth shows several white patches on the tongue and oral mucosa that can be easily scraped off with a tongue blade. On mental status examination, the patient is somnolent and has short-term memory deficits. The remainder of the examination shows no abnormalities. Laboratory studies show: Hemoglobin 13.6 g/dL Leukocyte count 9,600/mm3 Segmented neutrophils 80% Eosinophils 1% Lymphocytes 17% Monocytes 2% CD4+ T-lymphocytes 80/mm3 (Normal ≥ 500) Platelet count 328,000/mm3 Serum pH 7.36 Na+ 135 mEq/L Cl- 101 mEq/L K+ 4.8 mEq/L HCO3- 22 mEq/L Glucose 95 mg/dL Creatinine 0.9 mg/dL BUN 16 mg/dL Bilirubin, total 0.7 mg/dL AST 13 U/L ALT 15 U/L Erythrocyte sedimentation rate 10 mm/hour HIV test positive A lumbar puncture is performed and an opening pressure of 150 mm H2O is noted. Cerebrospinal fluid analysis shows a leukocyte count of 25/mm3 (60% lymphocytes), protein concentration of 52 mg/dL, and a glucose concentration of 37 mg/dL. India ink stain shows organisms with prominent capsules. Blood cultures are drawn. Which of the following is the most appropriate pharmacotherapy for this patient's neurological symptoms?"   (A) Pyrimethamine, sulfadiazine, and folinic acid   (B) Amphotericin B and flucytosine   (C) Fluconazole   (D) Vancomycin and meropenem
['(B) Amphotericin B and flucytosine <> answer', 'The following are multiple choice questions (with answers) about medical knowledge. <> instruction', '(A) Pyrimethamine, sulfadiazine, and folinic acid \n (B) Amphotericin B and flucytosine \n (C) Fluconazole \n (D) Vancomycin and meropenem <> possible answers', '  A 46-year-old man comes to the emergency department because of a 4-week history of fatigue and headache that have gotten progressively worse. He has allergic asthma treated with inhaled salbutamol. He immigrated to the USA from Thailand 9 years ago. He lives by himself and works as a waiter in a restaurant. He has had 6 lifetime male sexual partners and uses condoms inconsistently. He drinks 1–2 beers daily. His temperature is 38.2°C (100.8°F), pulse is 88/min, and blood pressure is 128/76 mm Hg. Examination of the mouth shows several white patches on the tongue and oral mucosa that can be easily scraped off with a tongue blade. On mental status examination, the patient is somnolent and has short-term memory deficits. The remainder of the examination shows no abnormalities. Laboratory studies show:\nHemoglobin 13.6 g/dL\nLeukocyte count 9,600/mm3\nSegmented neutrophils 80%\nEosinophils 1%\nLymphocytes 17%\nMonocytes 2%\nCD4+ T-lymphocytes 80/mm3 (Normal ≥ 500)\nPlatelet count 328,000/mm3\nSerum\npH 7.36\nNa+ 135 mEq/L\nCl- 101 mEq/L\nK+ 4.8 mEq/L\nHCO3- 22 mEq/L\nGlucose 95 mg/dL\nCreatinine 0.9 mg/dL\nBUN 16 mg/dL\nBilirubin, total 0.7 mg/dL\nAST 13 U/L\nALT 15 U/L\nErythrocyte sedimentation rate 10 mm/hour\nHIV test positive\nA lumbar puncture is performed and an opening pressure of 150 mm H2O is noted. Cerebrospinal fluid analysis shows a leukocyte count of 25/mm3 (60% lymphocytes), protein concentration of 52 mg/dL, and a glucose concentration of 37 mg/dL. India ink stain shows organisms with prominent capsules. Blood cultures are drawn. Which of the following is the most appropriate pharmacotherapy for this patient\'s neurological symptoms?" <> context@']