The following are multiple choice questions (with answers) about medical knowledge.   **Question:** A 53-year-old male presents to his primary care physician complaining of fatigue and joint and muscle pain. He reports a 6-month history of slowly progressive tiredness associated with dull achy pain in his knees, hips, and shoulders. His past medical history is notable for hypertension, diabetes, and stable angina. He takes lisinopril, metformin, glyburide, and aspirin. He has a history of intravenous drug use and was homeless in his early 30’s. He drinks alcohol socially and has a 30 pack-year smoking history. His temperature is 98.6°F (37°C), blood pressure is 130/85 mmHg, pulse is 95/min, and respirations are 18/min. Physical examination reveals a generally well-appearing male without evidence of ascites, peripheral edema, or jaundice. Results from laboratory tests are below:  Hepatitis A IgM: Negative Hepatitis A IgG: Negative Hepatitis B surface antigen: Negative Hepatitis B E antigen: Negative Hepatitis B core antigen: Negative Hepatitis B surface IgG: Positive Hepatitis B E IgG: Negative Hepatitis B core IgG: Negative Hepatitis C IgG: Positive HCV RNA: 100,000,000 IU/ml  This patient should be started on which of the following medications?   (A) Sofosbuvir and simeprevir   (B) Interferon-gamma   (C) Ribavirin   (D) Lamivudine
['(A) Sofosbuvir and simeprevir <> answer', 'The following are multiple choice questions (with answers) about medical knowledge. <> instruction', '(A) Sofosbuvir and simeprevir \n (B) Interferon-gamma \n (C) Ribavirin \n (D) Lamivudine <> possible answers', '  A 53-year-old male presents to his primary care physician complaining of fatigue and joint and muscle pain. He reports a 6-month history of slowly progressive tiredness associated with dull achy pain in his knees, hips, and shoulders. His past medical history is notable for hypertension, diabetes, and stable angina. He takes lisinopril, metformin, glyburide, and aspirin. He has a history of intravenous drug use and was homeless in his early 30’s. He drinks alcohol socially and has a 30 pack-year smoking history. His temperature is 98.6°F (37°C), blood pressure is 130/85 mmHg, pulse is 95/min, and respirations are 18/min. Physical examination reveals a generally well-appearing male without evidence of ascites, peripheral edema, or jaundice. Results from laboratory tests are below:\n\nHepatitis A IgM: Negative\nHepatitis A IgG: Negative\nHepatitis B surface antigen: Negative\nHepatitis B E antigen: Negative\nHepatitis B core antigen: Negative\nHepatitis B surface IgG: Positive\nHepatitis B E IgG: Negative\nHepatitis B core IgG: Negative\nHepatitis C IgG: Positive\nHCV RNA: 100,000,000 IU/ml\n\nThis patient should be started on which of the following medications? <> context@']