MultiCaRe
Collection
MultiCaRe: Open-Source Clinical Case Dataset
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11
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{
"authors": [
"Wenhua Liang",
"Jingjing Lu",
"Mingwei Qin",
"Xinting Sang"
],
"case_amount": 1,
"doi": "10.1258/arsr.2012.120031",
"journal": "Acta Radiol Short Rep",
"journal_detail": "2012 Jul 31;1(6):arsr.2012.120031.",
"keywords": [
"vascular tumor",
"diagnostic imaging",
"liver",
"pathology",
"spleen"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/23986846/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC3738355",
"pmid": "23986846",
"title": "Littoral cell angioma mimicking hepatic tumor",
"year": "2012"
}
|
PMC3738355
|
Littoral cell angioma is a rare vascular tumor of the spleen that was described by Falk et al. in 1991. Because of the limited number, untypical imaging manifestations, and lack of knowledge on this tumor type, these tumors are often misdiagnosed. In most cases, the tumor presents with multiple small hypoattenuating nodules in the spleen with delayed enhancement. However, solitary littoral cell angiomas have not been well described. We present the CT features of an unusual littoral cell angioma mimicking hepatic tumor.
|
{
"authors": [
"Payal J Shah",
"Brian Ellis",
"Lauren R DiGiovine",
"Jeffery P Hogg",
"Monique J Leys"
],
"case_amount": 1,
"doi": "10.3205/oc000036",
"journal": "GMS Ophthalmol Cases",
"journal_detail": "2015 Dec 2;5:Doc14.",
"keywords": [
"mri",
"aortic arch",
"carotid artery stenosis",
"carotid duplex ultrasound",
"ocular ischemic syndrome",
"panretinal laser",
"retrobulbar block"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/27625958/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC5015624",
"pmid": "27625958",
"title": "Central retinal artery occlusion following laser treatment for ocular ischemic aortic arch syndrome",
"year": "2015"
}
|
PMC5015624
|
Objective:
Ocular ischemic syndrome is a rare blinding condition generally caused by disease of the carotid artery. We describe a 69-year-old female with a 50 pack-year smoking history with aortic arch syndrome causing bilateral ocular ischemic syndrome.
Methods:
The patient presented with progressive visual loss and temple pain. Slit lamp biomicroscopy revealed bilateral iris neovascularization. This finding prompted a cardiovascular work up. Panretinal photocoagulation with retrobulbar block was performed in the right eye.
Results:
A temporal artery biopsy was negative. The carotid duplex ultrasound showed only a 1-39% stenosis. MRA revealed a more proximal occlusion of the aortic branch for which she underwent subclavian carotid bypass surgery. At the one month follow up, the right eye suffered profound vision loss secondary to a central retinal artery occlusion.
Conclusion:
Ocular neovascularization may be one of the clinical manifestations of aortic arch syndrome. This case also illustrates the limitations of relying solely on carotid duplex ultrasound testing. We caution against overly aggressive panretinal photocoagulation utilizing retrobulbar anesthesia.
|
{
"authors": [
"Nobuhiko Seki",
"Maika Natsume",
"Ryosuke Ochiai",
"Terunobu Haruyama",
"Masashi Ishihara",
"Yoko Fukasawa",
"Takahiko Sakamoto",
"Shigeru Tanzawa",
"Ryo Usui",
"Takeshi Honda",
"Shuji Ota",
"Yasuko Ichikawa",
"Kiyotaka Watanabe"
],
"case_amount": 1,
"doi": "10.1159/000493088",
"journal": "Case Rep Oncol",
"journal_detail": "2019 Jan 21;12(1):91-97.",
"keywords": [
"bevacizumab",
"egfr mutation",
"erlotinib",
"lung cancer",
"met amplification"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/30792648/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC6381877",
"pmid": "30792648",
"title": "Promising Combination Therapy with Bevacizumab and Erlotinib in an EGFR-Mutated NSCLC Patient with MET Amplification Who Showed Intrinsic Resistance to Initial EGFR-TKI Therapy",
"year": "2019"
}
|
PMC6381877
|
In lung cancer, several potential mechanisms of intrinsic and acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been explored, including mesenchymal-epithelial transition factor (MET) signaling pathway activation. On the other hand, vascular endothelial growth factor (VEGF) production of EGFR-mutated lung cancer cells is stimulated by predominantly activated MET signaling pathway. Therefore, the inhibition of VEGF axis as the downstream target of MET signaling pathway seems promising. Here, for the first time, we report the potential efficacy of combination therapy with bevacizumab and erlotinib in an EGFR-mutated NSCLC patient with MET amplification who showed intrinsic resistance to initial EGFR-TKI therapy. The patient was a 60-year-old male smoker, showing performance status (PS) 2, who presented with stage IV lung adenocarcinoma (cT4N2M1a) harboring the EGFR exon 19 deletion mutation. He was started on gefitinib at 250 mg/day. However, by 28 days, his symptoms further deteriorated along with the increased tumor size, resulting in PS 3. Then, repeat biopsy was performed, showing the positive MET amplification and the preserved EGFR exon 19 deletion mutation. Therefore, on the basis of the potential efficacy for activated MET signaling pathway as well as the confirmed safety by the known phase II trial for EGFR-mutated patients, the patient was started on combination therapy with bevacizumab at 15 mg/kg every 3 weeks plus erlotinib at 150 mg/day. By 21 days, his symptoms gradually improved along with the decreased tumor size, resulting in better PS with no severe toxicities.
|
{
"authors": [
"Ali Raza Ghani",
"Faisal Inayat",
"Nouman Safdar Ali",
"Reema Anjum",
"Michael Viray",
"Arsalan Talib Hashmi",
"Iqra Riaz",
"Bruce D Klugherz",
"Hafeez Ul Hassan Virk"
],
"case_amount": 9,
"doi": "10.1177/2324709618770479",
"journal": "J Investig Med High Impact Case Rep",
"journal_detail": "2018 Apr 18;6:2324709618770479.",
"keywords": [
"acute coronary syndrome",
"diagnosis",
"fibromuscular dysplasia",
"management",
"myocardial infarction",
"pregnancy-associated spontaneous coronary artery dissection",
"spontaneous coronary artery dissection"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/29707593/",
"major_mesh_terms": [],
"mesh_terms": [],
"pmcid": "PMC5912312",
"pmid": "29707593",
"title": "Spontaneous Coronary Artery Dissection: A Case Series of 9 Patients With Literature Review",
"year": "2018"
}
|
PMC5912312
|
Spontaneous coronary artery dissection is an increasingly recognized nonatherosclerotic cause of acute coronary syndrome. Reports regarding the prognosis and natural history of this disease are limited. In addition to the diagnostic difficulty, this condition poses a significant therapeutic challenge due to the lack of specific management guidelines. We present here a case series of 9 patients with spontaneous coronary artery dissection. Additionally, this article reviews the incidence, clinical characteristics, risk factors, diagnostic modalities, therapeutic approaches, and patterns of recurrence in patients with spontaneous coronary artery dissection.
|
{
"authors": [
"Xiangyi Kong",
"Dongmei Li",
"Yanguo Kong",
"Dingrong Zhong"
],
"case_amount": 1,
"doi": "10.1097/MD.0000000000005657",
"journal": "Medicine (Baltimore)",
"journal_detail": "2017 Jan;96(4):e5657.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/28121922/",
"major_mesh_terms": [
"Adenoma, Oxyphilic / pathology",
"Ki-67 Antigen / analysis",
"Neoplasm Recurrence, Local / pathology",
"Pituitary Gland, Anterior / pathology",
"Pituitary Neoplasms / pathology"
],
"mesh_terms": [
"Adenoma, Oxyphilic / pathology",
"Ki-67 Antigen / analysis",
"Neoplasm Recurrence, Local / pathology",
"Pituitary Gland, Anterior / pathology",
"Pituitary Neoplasms / pathology",
"Case Reports",
"Adenoma, Oxyphilic / chemistry",
"Adult",
"Humans",
"Male",
"Neoplasm Recurrence, Local / chemistry",
"Pituitary Neoplasms / chemistry",
"Ki-67 Antigen"
],
"pmcid": "PMC5287946",
"pmid": "28121922",
"title": "Malignant adenohypophysis spindle cell oncocytoma with repeating recurrences and a high Ki-67 index",
"year": "2017"
}
|
PMC5287946
|
Adenohypophysis spindle cell oncocytoma (ASCO) is a rare tumor recently reported by Roncaroli et al in 2002. This tumor is considered a grade I tumor by the World Health Organization.We report a rare case of malignant ASCO with repeating recurrences and a high Ki-67 index-a challenging diagnosis guided by clinical presentations, radiological signs, and postoperative pathological tests.We represent a 30-year-old man who had suffered from headaches, diplopia, and impaired visual field and acuity. His magnetic resonance imaging revealed an abnormal sellar mass and was originally misdiagnosed as a pituitary macroadenoma. We present detailed analysis of the patient's disease course and review relevant literature.When surgically treated, the specimen revealed a typical histopathology pattern of ASCO. The tumor recurred for several times and the patient underwent 3 surgeries and 1 γ-knife treatment, which was accompanied by a continuously increasing Ki-67 index.This is the first reported case of malignant ASCO (WHO III-IV grade). Despite its rarity, ASCO should be considered in the differential diagnosis of sellar lesions that mimic pituitary adenomas.
|
{
"authors": [
"Rutuja Gajanan Vidhale",
"Subraj Shetty",
"Nikita Kamble",
"Treville Pereira"
],
"case_amount": 1,
"doi": "10.4103/jomfp.jomfp_214_21",
"journal": "J Oral Maxillofac Pathol",
"journal_detail": "2022 Jan-Mar;26(1):101-103.",
"keywords": [
"mucocele",
"mucus extravasation cyst",
"myxoglobulosis"
],
"license": "CC BY-NC-SA",
"link": "https://pubmed.ncbi.nlm.nih.gov/35571290/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC9106225",
"pmid": "35571290",
"title": "A novel mucocele: Myxoglobulosis",
"year": "2022"
}
|
PMC9106225
|
Oral extravasation mucoceles are among the most widely recognized submucosal lesions which are usually a result of trauma involving salivary glands and their ducts. This paper reports a case of a 40-year-old female patient with a chief complaint of a painless swelling on the lower lip since 6 months. Upon a provisional diagnosis of mucocele, surgical excision was carried out. Histopathological examination revealed a mucus extravasation cyst having lumen filled with unique mucinous globular structures similar to a rare variant of appendiceal mucocele, myxoglobulosis.
|
{
"authors": [
"Liaqat A Khan",
"Ali M Al-Neami",
"Ayman F Soliman",
"Alaa A M Khaled",
"Mohammed I H Tawhari",
"Yahya A Athlawy"
],
"case_amount": 1,
"doi": "10.1016/j.ijscr.2020.03.051",
"journal": "Int J Surg Case Rep",
"journal_detail": "2020;71:364-366.",
"keywords": [
"bochdalek",
"diaphragm",
"emergency care",
"hernia",
"physician",
"retrocardiac",
"spleen"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/32506006/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC7276389",
"pmid": "32506006",
"title": "Bochdalek hernia with retrocardiac spleen - Diagnostic dilemma for emergency care physicians-A case report",
"year": "2020"
}
|
PMC7276389
|
Introduction:
Physicians working as first-level responders in emergency departments (ED) often encounter patients, of any age group with shortness of breath (SOB). Definitive diagnosis is quite challenging once the underlying pathology is rare and unusual and/or the ED physicians recommend and rely on non-specific investigations.
Presentation of case:
A 29-year-old female presented to the emergency department with sudden onset of shortness of breath and upper abdominal pain radiating to the left shoulder. Diagnosis of Bochdalek hernia was made clinically coupled with radiological findings of CXR and computed tomography (CT) by the surgeon on-call, while it was missed by an emergency care physician on her first visit.
Discussion:
Herniation of the abdominal contents into the thoracic cavity via the Bochdalek opening, commonly known as Bochdalek hernia is seen and diagnosed most commonly accidentally in early life. Adult cases of symptomatic Bochdalek hernia has been reported in the literature. These patients usually present with non-specific symptoms, thus pose a diagnostic challenge for an emergency care physician.
Conclusion:
The report of this case highlights the notion that such rare causes of acute onset dyspnea and upper abdominal pain pose a diagnostic challenge for novice emergency care physicians especially in situations where he/she does not ask for second-line help in general and recommend and rely on a non-specific investigation in specific.
|
{
"authors": [
"Ryuji Kawaguchi",
"Naoto Furukawa",
"Yoshihiko Yamada",
"Hidekazu Ooi",
"Hiroshi Kobayashi"
],
"case_amount": 2,
"doi": "10.1159/000330239",
"journal": "Case Rep Oncol",
"journal_detail": "2011;4(2):358-62.",
"keywords": [
"alpha-fetoprotein",
"hepatoid adenocarcinoma",
"rhabdomyosarcoma",
"uterine carcinosarcoma"
],
"license": "CC BY-NC-ND",
"link": "https://pubmed.ncbi.nlm.nih.gov/21769295/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC3134036",
"pmid": "21769295",
"title": "Carcinosarcoma of the uterine corpus with alpha-fetoprotein-producing hepatoid adenocarcinoma: a report of two cases",
"year": "2011"
}
|
PMC3134036
|
We report two cases of uterine carcinosarcoma associated with alpha-fetoprotein (AFP)-producing hepatoid adenocarcinoma. Samples were obtained from two women aged 63 and 82 years. Serum AFP levels of the two samples were 10,131 and 401 ng/ml, respectively. Histologically, in both cases the tumor cells were composed of hepatoid adenocarcinoma component and sarcoma component including rhabdomyosarcoma. Immunohistochemical analyses revealed that AFP was expressed in the cytoplasm of the carcinomatous component. After surgery, the patients received six courses of carboplatin/paclitaxel chemotherapy, and the serum levels of AFP decreased to normal range. The first patient is alive and well at the 2-year follow-up, while the second patient died of disease 1 year after initial operative treatment. This is, to our knowledge, the second report of carcinosarcoma of the uterine corpus with AFP-producing hepatoid adenocarcinoma, as proven by immunohistochemical analyses.
|
{
"authors": [
"Ludovica Fucci",
"Lorenzo Gensini",
"Ugo Coppetelli",
"Elettra Ortu La Barbera",
"Martina Gentile",
"Luciano Fiori",
"Salvatore Perrone",
"Giuseppe Cimino"
],
"case_amount": 1,
"doi": "10.1016/j.lrr.2022.100330",
"journal": "Leuk Res Rep",
"journal_detail": "2022 May 30;17:100330.",
"keywords": [
"daratumumab",
"multiple myeloma",
"real-word experience",
"relapsed refractory"
],
"license": "CC BY-NC-ND",
"link": "https://pubmed.ncbi.nlm.nih.gov/35694449/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC9184873",
"pmid": "35694449",
"title": "Daratumumab triplet therapies in patients with relapsed or refractory multiple myeloma: A \"real world\" experience",
"year": "2022"
}
|
PMC9184873
|
We report our retrospective analysis on 34 relapsed/refractory multiple myeloma (RRMM) patients treated with daratumumab based triplets. Twenty patients were females and 14 males. Median age was 73.2. Daratumumab was associated to lenalidomide in and dexamethasone (DRd) in 30 (88,3%) and to bortezomib and dexamethasone (DVd) in 4 cases (11,7%). The ORR was 88%. CR occurred in 12% of cases, VGPR in 44% and PR in 32%. The 12 months PFS and OS rates were 78% and 86,5%, respectively. Present data confirm those recently reported in the literature and further reinforce the early use of daratumumab-based triplets for RRMM patients.
|
{
"authors": [
"Pradyumna Agasthi",
"Hemalatha Narayanasamy",
"Dan Sorajja",
"James Slack",
"Farouk Mookadam"
],
"case_amount": 1,
"doi": "10.1155/2018/3953579",
"journal": "Case Rep Cardiol",
"journal_detail": "2018 Sep 30;2018:3953579.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/30363961/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC6186336",
"pmid": "30363961",
"title": "Decitabine Induced Delayed Cardiomyopathy in Hematologic Malignancy",
"year": "2018"
}
|
PMC6186336
|
Decitabine is a pyrimidine analogue of nucleoside cytidine, used for the treatment of myelodysplastic syndromes, chronic myelogenous leukemia, and acute myelogenous leukemia. We present a case of cardiomyopathy associated with decitabine used for secondary acute myelogenous leukemia. The patient presented with new heart failure symptoms and an ejection fraction decline.
|
{
"authors": [
"Nnenna E Ikeogu",
"Satyam Singh",
"Helai Hussaini",
"Zainab Omar",
"Sakshi Lakhra",
"Khalid H Mohamed",
"Munira Abdefatah Ali",
"Enoh Nguty Nkeng",
"Tulika Garg",
"Aadil Khan"
],
"case_amount": 1,
"doi": "10.7759/cureus.33931",
"journal": "Cureus",
"journal_detail": "2023 Jan 18;15(1):e33931.",
"keywords": [
"albendazole",
"dress syndrome",
"neurocysticercosis",
"taenia solium",
"tumour necrosis factor-alpha (tnfα)"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/36819416/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC9937515",
"pmid": "36819416",
"title": "Cysticercal Encephalitis in a Young Female: A Rare Presentation of Neurocysticercosis",
"year": "2023"
}
|
PMC9937515
|
One of the most frequent parasite infections of the central nervous system is neurocysticercosis. This neurologic condition is caused by Taenia solium (T. solium) larval infestation. Infected pork intake, poor hygiene practices, water tainted with T. solium, or asymptomatic carriers are the main ways of spread. We describe a case of neurocysticercosis in a young woman who presented with low-grade fever, headache, altered sensorium, and recurrent seizures. Computed tomography of the head revealed an inflammatory granuloma and a ring-increased attenuating lesion in the left temporal region. Additionally, a well-defined rounded discrete lesion was identified in the left parietal region on magnetic resonance imaging of the brain. Even if the symptoms do not initially suggest neurocysticercosis or if the patient lives in a region where the condition is uncommon, our case depicts adding neurocysticercosis to the differential diagnosis for encephalitis.
|
{
"authors": [
"Jing Wang",
"Wei Hu",
"Kexin Wang",
"Rong Yu",
"Liwen Chang",
"Zhihui Rong"
],
"case_amount": 4,
"doi": "10.3389/fped.2023.1179402",
"journal": "Front Pediatr",
"journal_detail": "2023 May 5;11:1179402.",
"keywords": [
"covid-19",
"omicron variant",
"sars-cov-2",
"acute hepatitis",
"liver injury",
"neonate",
"transaminase"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/37215592/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10196249",
"pmid": "37215592",
"title": "Case report: Acute hepatitis in neonates with COVID-19 during the Omicron SARS-CoV-2 variant wave: a report of four cases",
"year": "2023"
}
|
PMC10196249
|
Background:
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), first emerging in December 2019 and continuously evolving, poses a considerable challenge worldwide. It was reported in the literature that neonates had mild upper respiratory symptoms and a better outcome after Omicron SARS-CoV-2 variant infection, but there was insufficient data about complications and prognosis.
Case presentation:
In this paper, we present the clinical and laboratory characteristics of four COVID-19 neonate patients with acute hepatitis during the Omicron SARS-CoV-2 variant wave. All patients had a clear history of Omicron exposure and were infected via contact with confirmed caregivers. Low to moderate fever and respiratory symptoms were the primary clinical manifestations, and all patients had a normal liver function at the initial stage of the course. Then, the fever lasted 2 to 4 days, and it was noted that hepatic dysfunction might have occurred 5 to 8 days after the first onset of fever, mainly characterized by moderate ALT and AST elevation (>3 to 10-fold of upper limit). There were no abnormalities in bilirubin levels, blood ammonia, protein synthesis, lipid metabolism, and coagulation. All the patients received hepatoprotective therapy, and transaminase levels gradually decreased to the normal range after 2 to 3 weeks without other complications.
Conclusions:
This is the first case series about moderate to severe hepatitis in COVID-19 neonatal patients via horizontal transmission. Besides fever and respiratory symptoms, the clinical doctor should pay much attention to evaluating the risk of liver function injury after SARS-CoV-2 variants infection, which is usually asymptomatic and has a delayed onset.
|
{
"authors": [
"Carol George",
"Anna Buchheim"
],
"case_amount": 2,
"doi": "10.3389/fpsyg.2014.00865",
"journal": "Front Psychol",
"journal_detail": "2014 Aug 5;5:865.",
"keywords": [
"adult attachment projective picture system",
"adult attachment",
"psychoanalysis",
"psychotherapy",
"trauma"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/25140164/",
"major_mesh_terms": [],
"mesh_terms": [],
"pmcid": "PMC4122203",
"pmid": "25140164",
"title": "Use of the adult attachment projective picture system in psychodynamic psychotherapy with a severely traumatized patient",
"year": "2014"
}
|
PMC4122203
|
The following case study is presented to facilitate an understanding of how the attachment information evident from Adult Attachment Projective Picture System (AAP) assessment can be integrated into a psychodynamic perspective in making therapeutic recommendations that integrate an attachment perspective. The Adult Attachment Projective Picture System (AAP) is a valid representational measure of internal representations of attachment based on the analysis of a set of free response picture stimuli designed to systematically activate the attachment system (George and West, 2012). The AAP provides a fruitful diagnostic tool for psychodynamic-oriented clinicians to identify attachment-based deficits and resources for an individual patient in therapy. This paper considers the use of the AAP with a traumatized patient in an inpatient setting and uses a case study to illustrate the components of the AAP that are particularly relevant to a psychodynamic conceptualization. The paper discusses also attachment-based recommendations for intervention.
|
{
"authors": [
"Kostas Nizamis",
"Noortje H M Rijken",
"Robbert van Middelaar",
"João Neto",
"Bart F J M Koopman",
"Massimo Sartori"
],
"case_amount": 1,
"doi": "10.3389/fneur.2020.00231",
"journal": "Front Neurol",
"journal_detail": "2020 Apr 15;11:231.",
"keywords": [
"duchenne muscular dystrophy",
"forearm",
"hand",
"high-density surface electromyography",
"motor control",
"myocontrol",
"principal component analysis (pca)",
"wrist"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/32351441/",
"major_mesh_terms": [],
"mesh_terms": [],
"pmcid": "PMC7174775",
"pmid": "32351441",
"title": "Characterization of Forearm Muscle Activation in Duchenne Muscular Dystrophy via High-Density Electromyography: A Case Study on the Implications for Myoelectric Control",
"year": "2020"
}
|
PMC7174775
|
Duchenne muscular dystrophy (DMD) is a genetic disorder that results in progressive muscular degeneration. Although medical advances increased their life expectancy, DMD individuals are still highly dependent on caregivers. Hand/wrist function is central for providing independence, and robotic exoskeletons are good candidates for effectively compensating for deteriorating functionality. Robotic hand exoskeletons require the accurate decoding of motor intention typically via surface electromyography (sEMG). Traditional low-density sEMG was used in the past to explore the muscular activations of individuals with DMD; however, it cannot provide high spatial resolution. This study characterized, for the first time, the forearm high-density (HD) electromyograms of three individuals with DMD while performing seven hand/wrist-related tasks and compared them to eight healthy individuals (all data available online). We looked into the spatial distribution of HD-sEMG patterns by using principal component analysis (PCA) and also assessed the repeatability and the amplitude distributions of muscle activity. Additionally, we used a machine learning approach to assess DMD individuals' potentials for myocontrol. Our analysis showed that although participants with DMD were able to repeat similar HD-sEMG patterns across gestures (similarly to healthy participants), a fewer number of electrodes was activated during their gestures compared to the healthy participants. Additionally, participants with DMD activated their muscles close to maximal contraction level (0.63 ± 0.23), whereas healthy participants had lower normalized activations (0.26 ± 0.2). Lastly, participants with DMD showed on average fewer PCs (3), explaining 90% of the complete gesture space than the healthy (5). However, the ability of the DMD participants to produce repeatable HD-sEMG patterns was unexpectedly comparable to that of healthy participants, and the same holds true for their offline myocontrol performance, disproving our hypothesis and suggesting a clear potential for the myocontrol of wearable exoskeletons. Our findings present evidence for the first time on how DMD leads to progressive alterations in hand/wrist motor control in DMD individuals compared to healthy. The better understanding of these alterations can lead to further developments for the intuitive and robust myoelectric control of active hand exoskeletons for individuals with DMD.
|
{
"authors": [
"Misty Ruppert",
"John Pyun",
"K V Chalam",
"David Sierpina"
],
"case_amount": 2,
"doi": "10.1155/2020/8860863",
"journal": "Case Rep Genet",
"journal_detail": "2020 Dec 2;2020:8860863.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/33777460/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC7969344",
"pmid": "33777460",
"title": "Multimodal Imaging Characteristics of ADRP in a Family with p.Thr58Arg Substituted RHO Mutation",
"year": "2020"
}
|
PMC7969344
|
Background:
Autosomal dominant retinitis pigmentosa (adRP) is a rare cause of progressive visual impairment in young patients and is frequently a result of RHO gene mutations. p.Thr58Arg rhodopsin mutation leads to misfolding of rhodopsin, subsequent accumulation in the endoplasmic reticulum, and leads to consecutive atrophy of photoreceptor cells through apoptosis.
Materials and methods:
We describe multimodal imaging findings in a 58-year-old female with adRP due to a c.173 C > G, p.Thr58Arg rhodopsin mutation (confirmed on genotyping), including ultra-wide-field fundus autofluorescence (UWF-FAF), color scanning laser ophthalmoscopy, structural optical coherence tomography (OCT), OCT-angiography (OCT-A), electroretinography (ERG), and visual field testing (HVF). Additionally, we compare the patient's phenotypic findings to those of her offspring, who was also affected by adRP.
Results:
The 58-year-old female and her son with symptoms of nyctalopia and decreased vision showed macular pigmentary changes in a bull's-eye pattern along with bone spicules in periphery with retinal atrophy. Genotyping confirmed p.Thr58Arg rhodopsin mutation. Wide area of dystrophic retina was noted on UWF-FAF, along with corresponding atrophy of photoreceptor layer on OCT. OCTA revealed complete nonperfusion of the superficial capillary plexus in areas of retinal dystrophy. ERG revealed increased latency and decreased amplitudes; HVF revealed constriction of visual fields consistent with retinal findings.
Conclusions:
Multimodal imaging is extremely helpful in delineating the extent of retinal dystrophy and comparable to ERG for monitoring of progress in retinitis pigmentosa. Photoreceptor layer thickness (measured with OCT) strongly correlated with ERG and can be used as a secondary surrogate for monitoring the disease progress.
|
{
"authors": [
"Xiaowei Liu",
"Yuekang Zhang",
"Si Zhang",
"Chuanyuan Tao",
"Yan Ju"
],
"case_amount": 1,
"doi": "10.3340/jkns.2015.0609.001",
"journal": "J Korean Neurosurg Soc",
"journal_detail": "2018 Jan;61(1):120-126.",
"keywords": [
"atypical meningioma",
"basal ganglia",
"intraparenchymal meningioma"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/29354244/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC5769854",
"pmid": "29354244",
"title": "Intraparenchymal Atypical Meningioma in Basal Ganglia Region in a Child: Case Report and Literature Review",
"year": "2018"
}
|
PMC5769854
|
Intraparenchymal meningiomas without dural attachment are extremely rare, especially when they occur in basal ganglia region in child. An 8-year-old boy was admitted at our hospital, complaining of recurrent headache and vomiting for 3 months. Neurological examination showed impaired vision and mild paresis of the left extremities. Magnetic resonance imaging demonstrated a lesion located in the right basal ganglia region extending to superasellar cistern with solid, multiple cystic and necrotic components. Computed tomography revealed calcification within the mass. Due to the anterior cerebral artery involvement, a subtotal resection was achieved and postoperative radiotherapy was recommended. Histopathological examination indicated that the lesion was an atypical meningioma. The postoperative rehabilitation was uneventful. Mildly impaired vision and motor weakness of left extremities improved significantly and the patient returned to normal life after surgery. To our knowledge, intraparenchymal atypical meningioma in basal ganglia extending to superasellar cistern was never reported. The significance in differential diagnosis of lesions in basal ganglia should be emphasized.
|
{
"authors": [
"Omron Hassan",
"Courtney S Lewis",
"Likitha Aradhyula",
"Brian R Hirshman",
"Martin H Pham"
],
"case_amount": 1,
"doi": "10.25259/SNI_166_2020",
"journal": "Surg Neurol Int",
"journal_detail": "2020 May 9;11:104.",
"keywords": [
"adjacent segment disease",
"epidural venous plexus",
"lumbar radiculopathy"
],
"license": "CC BY-NC-SA",
"link": "https://pubmed.ncbi.nlm.nih.gov/32494381/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC7265352",
"pmid": "32494381",
"title": "Engorged venous plexus mimicking adjacent segment disease: Case report and review of the literature",
"year": "2020"
}
|
PMC7265352
|
Background:
An engorged venous plexus may mimic nerve compression from a herniated disk on the magnetic resonance (MR) studies as they both have similar signal intensities. During a laminectomy, if an engorged venous plexus is encountered instead of a disk herniation, there may be marked unanticipated bleeding.
Case description:
A 58-year-old female who had a prior anterior lumbar interbody fusion later returned with recurrent radiculopathy. Adjacent segment disease from a spinal disk herniation was suspected based on the surgical history, physical examination, and imaging (MRI) findings. Rather than a disk, an engorged venous plexuses (EVP) was encountered intraoperatively.
Conclusion:
Here, we discussed our findings regarding a lumbar EVP rather than a herniated disk and reviewed the current literature. Although rare, a higher index of suspicion for these vascular malformations based on combined historical information and MRI studies should allow one to better detect and/or anticipate an EVP rather than a routine disk.
|
{
"authors": [
"Kevin Z Zhou",
"Robert Khor",
"Kenneth K Lau"
],
"case_amount": 1,
"doi": "10.1259/bjrcr.20170050",
"journal": "BJR Case Rep",
"journal_detail": "2017 Aug 4;3(4):20170050.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/30363204/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC6159178",
"pmid": "30363204",
"title": "Use of single photon metal artefact reduction in the detection of an impacted capsule endoscope",
"year": "2017"
}
|
PMC6159178
|
Wireless capsule endoscopy was introduced over a decade ago and is now a widely used tool in the investigation of gastrointestinal pathologies. Despite its ubiquity, the full profile of indications, contraindications and complications is still being developed. Metal artefact reduction is a software technique which can significantly reduce the artefact produced by metallic objects on CT scans. This case exemplifies a rare but noteworthy complication of capsule endoscopy and highlights a novel application of metal artefact reduction.
|
{
"authors": [
"Stéphane Helleringer",
"Géraldine Duthé",
"Almamy Malick Kanté",
"Armelle Andro",
"Cheikh Sokhna",
"Jean-François Trape",
"Gilles Pison"
],
"case_amount": 1,
"doi": "10.1111/tmi.12012",
"journal": "Trop Med Int Health",
"journal_detail": "2013 Jan;18(1):27-34.",
"keywords": null,
"license": "author_manuscript",
"link": "https://pubmed.ncbi.nlm.nih.gov/23130912/",
"major_mesh_terms": [
"Cause of Death",
"Data Collection / standards",
"Maternal Mortality",
"Mortality"
],
"mesh_terms": [
"Cause of Death",
"Data Collection / standards",
"Maternal Mortality",
"Mortality",
"Research Support, N.I.H., Extramural",
"Research Support, Non-U.S. Gov't",
"Adolescent",
"Adult",
"Autopsy",
"Child",
"Death Certificates",
"Female",
"Humans",
"Interviews as Topic",
"Middle Aged",
"Pregnancy",
"Retrospective Studies",
"Rural Population",
"Senegal / epidemiology",
"Siblings",
"Young Adult"
],
"pmcid": "PMC3678730",
"pmid": "23130912",
"title": "Misclassification of pregnancy-related deaths in adult mortality surveys: case study in Senegal",
"year": "2013"
}
|
PMC3678730
|
Objective:
In countries with limited vital registration data, maternal mortality levels are often estimated using siblings' survival histories (SSH) collected during retrospective adult mortality surveys. We explored how accurately adult deaths can be classified as pregnancy related using such data.
Method:
The study was conducted in a rural area of south-eastern Senegal with high maternal mortality, Bandafassi. We used data from a demographic surveillance system (DSS) in this area to identify deaths of women at reproductive ages between 2003 and 2009 and to locate the surviving adult sisters of the deceased and interview them. Siblings' survival histories were linked at the individual level to death records, and verbal autopsy data obtained by the demographic surveillance system. We compared the classification of adult female deaths as pregnancy related or not in interviews and DSS records.
Results:
There were 91 deaths at reproductive ages in the Bandafassi DSS between 2003 and 2009, but only 59 had known surviving sisters. Some deaths were omitted by respondents, or reported as alive or as having occurred during childhood (n = 8). Among deaths reported both in the SSH and DSS data, 94% of deaths classified as pregnancy related in the DSS data were also classified as such by siblings' survival histories. Only 70% of deaths classified as not pregnancy related in the DSS data were also classified as such by siblings' survival histories.
Conclusion:
Misclassifications of pregnancy-related deaths in retrospective adult mortality surveys may affect estimates of pregnancy-related mortality rates.
|
{
"authors": [
"Jian-Min Jin",
"Peng Bai",
"Wei He",
"Fei Wu",
"Xiao-Fang Liu",
"De-Min Han",
"Shi Liu",
"Jin-Kui Yang"
],
"case_amount": 1,
"doi": "10.3389/fpubh.2020.00152",
"journal": "Front Public Health",
"journal_detail": "2020 Apr 29;8:152.",
"keywords": [
"covid-19",
"sars",
"sars-cov-2",
"female",
"gender",
"male",
"morbidity",
"mortality"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/32411652/",
"major_mesh_terms": [
"COVID-19 / epidemiology",
"COVID-19 / mortality",
"Comorbidity",
"Severe Acute Respiratory Syndrome / epidemiology",
"Severe Acute Respiratory Syndrome / mortality",
"Severity of Illness Index"
],
"mesh_terms": [
"COVID-19 / epidemiology",
"COVID-19 / mortality",
"Comorbidity",
"Severe Acute Respiratory Syndrome / epidemiology",
"Severe Acute Respiratory Syndrome / mortality",
"Severity of Illness Index",
"Research Support, Non-U.S. Gov't",
"China / epidemiology",
"Cough / etiology",
"Female",
"Fever / etiology",
"Humans",
"Male",
"Middle Aged",
"SARS-CoV-2 / isolation & purification",
"Sex Factors"
],
"pmcid": "PMC7201103",
"pmid": "32411652",
"title": "Gender Differences in Patients With COVID-19: Focus on Severity and Mortality",
"year": "2020"
}
|
PMC7201103
|
Objective: The recent outbreak of Novel Coronavirus Disease (COVID-19) is reminiscent of the SARS outbreak in 2003. We aim to compare the severity and mortality between male and female patients with COVID-19 or SARS. Study Design and Setting: We extracted the data from: (1) a case series of 43 hospitalized patients we treated, (2) a public data set of the first 37 cases of patients who died of COVID-19 and 1,019 patients who survived in China, and (3) data of 524 patients with SARS, including 139 deaths, from Beijing in early 2003. Results: Older age and a high number of comorbidities were associated with higher severity and mortality in patients with both COVID-19 and SARS. Age was comparable between men and women in all data sets. In the case series, however, men's cases tended to be more serious than women's (P = 0.035). In the public data set, the number of men who died from COVID-19 is 2.4 times that of women (70.3 vs. 29.7%, P = 0.016). In SARS patients, the gender role in mortality was also observed. The percentage of males were higher in the deceased group than in the survived group (P = 0.015). Conclusion: While men and women have the same prevalence, men with COVID-19 are more at risk for worse outcomes and death, independent of age.
|
{
"authors": [
"Chen-Yu Wang",
"Ya-Qin Chen",
"Jie-Yuan Jin",
"Ran Du",
"Liang-Liang Fan",
"Rong Xiang"
],
"case_amount": 1,
"doi": "10.3389/fgene.2020.00755",
"journal": "Front Genet",
"journal_detail": "2020 Jul 15;11:755.",
"keywords": [
"abca8",
"atherosclerosis",
"cholesterol efflux",
"nonsense mutation",
"reduced hdl-c levels"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/32760429/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC7373792",
"pmid": "32760429",
"title": "A Novel Nonsense Mutation of ABCA8 in a Han-Chinese Family With ASCVD Leads to the Reduction of HDL-c Levels",
"year": "2020"
}
|
PMC7373792
|
Arteriosclerotic cardiovascular disease (ASCVD) is one of the major causes of death worldwide and most commonly develops as a result of atherosclerosis (AS). As we all know, dyslipidemia is a leading pathogenic risk factor for ASCVD, which leads to cardiac ischemic injury and myocardial infarction. Dyslipidemias include hypercholesterolemia, hypertriglyceridemia, increased low-density lipoprotein cholesterol (LDL-c) and decreased high density lipoproteins cholesterol (HDL-c). Mutations of dyslipidemia related genes have been proved to be the crucial contributor to the development of AS and ASCVD. In this study, a Han-Chinese family with ASCVD was enrolled and the lipid testing discovered an obvious reduced levels of HDL-c in the affected members. We then performed whole exome sequencing to detect the candidate genes of the family. After data filtering, a novel heterozygous nonsense mutation (NM_007168: c.3460C>T; p.R1154X) of ABCA8 was detected and validated to be co-separated in the family members by Sanger sequencing. Previous studies have proved that deleterious heterozygous ABCA8 variants may disrupt cholesterol efflux and reduce HDL-c levels in humans and mice. This study may be the second report related to ABCA8 mutations in patients with reduced levels of HDL-c. Our study not only contributed to the genetic counseling and prenatal genetic diagnosis of patients with ASCVD caused by reduced HDL-c levels, but also provided a new sight among ABCA8, cholesterol efflux and HDL-c levels.
|
{
"authors": [
"Júlia D Rossetto",
"Eliana A Forno",
"Melina Correia Morales",
"Julio Cesar Moreira",
"Pedro V Ferrari",
"Bruno T Herrerias",
"Flavio E Hirai",
"Carolina P B Gracitelli"
],
"case_amount": 1,
"doi": "10.1159/000513958",
"journal": "Case Rep Ophthalmol",
"journal_detail": "2021 Apr 19;12(1):270-276.",
"keywords": [
"eyelid diseases",
"hordeolum",
"necrosis",
"necrotizing fasciitis"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/34054469/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC8138243",
"pmid": "34054469",
"title": "Upper Eyelid Necrosis Secondary to Hordeolum: A Case Report",
"year": "2021"
}
|
PMC8138243
|
We reported a case of upper eyelid necrosis initially misdiagnosed as a preseptal cellulitis following a hordeolum externum resulting in great damage to the upper eyelid (anterior lamella). The infection was successfully treated with surgical cleansing, drainage, and endovenous antibiotics. Early treatment may avoid severe complications such as eyelid deformity, systemic involvement, and blindness.
|
{
"authors": [
"Hae Lang Park",
"Seung Mo Lim",
"Tae Hwa Kim",
"Kyung Ho Kang",
"Hyun Kang",
"Yong Hun Jung",
"Chong Wha Baek",
"Young Cheol Woo",
"Jin Yun Kim",
"Gill Hoi Koo",
"Hwa Yong Shin"
],
"case_amount": 1,
"doi": "10.3344/kjp.2013.26.1.62",
"journal": "Korean J Pain",
"journal_detail": "2013 Jan;26(1):62-4.",
"keywords": [
"facial nerve",
"hemifacial spasm",
"pulsed radiofrequency treatment"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/23342210/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC3546213",
"pmid": "23342210",
"title": "Intractable hemifacial spasm treated by pulsed radiofrequency treatment",
"year": "2013"
}
|
PMC3546213
|
Hemifacial spasm is defined as unilateral, involuntary, irregular twitching of all or parts of the muscles innervated by facial nerves. Here, we present a case of recurrent hemifacial spasm after microvascular decompression (MVD) treated with pulsed radiofrequency (PRF) treatment with good results. A 35-year-old woman suffered from recurrent hemifacial spasm after MVD that was refractory to medical treatment and botulinum toxin injections. We attempted a left facial nerve block twice. Then, we applied PRF at a maximum temperature of 42℃ for 120 sec. Some response was observed, so we applied PRF two additional times. The frequency of twitch decreased from 3-4 Hz to < 0.5 Hz, and subjective severity on a visual analogue scale also decreased from 10/10 to 2-3/10. PRF treatment might be an effective medical treatment for refractory hemifacial spasm and has fewer complications and is less invasive compared with those of surgery.
|
{
"authors": [
"Shuai-Jie Lv",
"Zheng-Ming Wang",
"Rui Wang",
"Heng-Kai Jin",
"Pei-Jian Tong",
"Xun Liu"
],
"case_amount": 1,
"doi": "10.3389/fsurg.2022.1067306",
"journal": "Front Surg",
"journal_detail": "2023 Jan 6;9:1067306.",
"keywords": [
"psi",
"case report",
"extra-articular deformity",
"haemophilic arthritis",
"total knee arthroplasty"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/36684182/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC9852490",
"pmid": "36684182",
"title": "Total knee arthroplasty and femoral osteotomy with a patient-specific cutting guide to treat haemophilic arthritis with severe extra-articular deformity: A case report and review of literatures",
"year": "2023"
}
|
PMC9852490
|
Background:
Total knee arthroplasty (TKA) is recommended for haemophilic patients with end-stage arthritis. TKA combined with a one-stage extraarticular osteotomy is uncommon in the treatment of haemophilic arthritis (HA) with severe extra-articular deformities (EADs) and a history of inhibitors under the guidance of a patient-specific cutting guide (PSI).
Case presentation:
We reported a 20-year-old male patient with severe haemophilia, limited knee functionality, a 30° sagittal deformity on the femoral side and a history of inhibitors. We adopted the Van Creveld protocol to decrease the inhibitors. TKA and extra-articular osteotomy (EAO) were performed simultaneously and sequentially under the guidance of PSI. An appropriate central alignment of the lower limb was restored by using cement prostheses with antibiotics and femur shaft locking compression plates. The last follow-up showed that the knee function was good, the VAS score was 0, the WOMAC score was 18 and the ROM was 0°-95°.
Conclision:
Regular haematology management can reduce the perioperative bleeding risk in haemophilic patients treated with inhibitors. PSI plays an important role in guiding the TKA and EAO of end-stage HA patients with severe EAD.
|
{
"authors": [
"Kamal Khademvatani",
"Yousef Rezaei",
"Abdollah Kerachian",
"Mir Hossein Seyyed-Mohammadzad",
"Ramin Eskandari",
"Alireza Rostamzadeh"
],
"case_amount": 1,
"doi": "10.12659/AJCR.890607",
"journal": "Am J Case Rep",
"journal_detail": "2014 Jul 13;15:300-3.",
"keywords": [
"echocardiography",
"leiomyoma",
"pulmonary embolism",
"thrombolytic therapy"
],
"license": "NO-CC CODE",
"link": "https://pubmed.ncbi.nlm.nih.gov/25061497/",
"major_mesh_terms": [
"Pulmonary Embolism / etiology",
"Uterine Neoplasms / complications"
],
"mesh_terms": [
"Pulmonary Embolism / etiology",
"Uterine Neoplasms / complications",
"Case Reports",
"Review",
"Acute Disease",
"Adult",
"Diagnosis, Differential",
"Echocardiography, Transesophageal",
"Electrocardiography",
"Female",
"Follow-Up Studies",
"Humans",
"Leiomyoma",
"Magnetic Resonance Imaging",
"Neoplasm Staging",
"Pulmonary Embolism / diagnosis",
"Uterine Neoplasms / diagnosis"
],
"pmcid": "PMC4108191",
"pmid": "25061497",
"title": "Acute pulmonary embolism caused by enlarged uterine leiomyoma: a rare presentation",
"year": "2014"
}
|
PMC4108191
|
Patient:
Female, 42.
Final diagnosis:
Acute pulmonary embolism.
Symptoms:
Chest pain • dyspnea.
Medication:
Streptokinase • Warfarin.
Clinical procedure:
.-
Specialty:
Cardiology and Neoplasm.
Objective:
Management of emergency care.
Background:
Deep venous thrombosis (DVT) and subsequent pulmonary embolism (PE) caused by pelvic vein compression are rare and life-threatening complications of leiomyoma of the uterus.
Case report:
We report a 42-year-old virgin woman with a history of leiomyoma who presented to the emergency department with complaints of dyspnea and pleuritic chest pain with transient spotting. On physical examination, she had a non-tender abdomen with a 20-week size uterus. Imaging investigations revealed an acute DVT in her left leg and a huge uterine-derived mass compressing the common iliac veins. Transesophageal echocardiography (TEE) demonstrated an echogenic mass in her right pulmonary artery consistent with thrombosis. The patient was completely cured using thrombolytic therapy and myomectomy, and was well at 1 year after thrombolysis.
Conclusions:
PE caused by pelvic vein compression is a rare complication of leiomyoma, which should be considered. Thrombolytic therapy associated with myomectomy can be implemented for treating such cases, and TEE can be used for diagnosing suspected high-risk PE.
|
{
"authors": [
"George-Adrian Ciobanu",
"Mircea Ionuţ Gheorghiţă",
"Octavian Mihnea Petrescu",
"Sanda Mihaela Popescu",
"Ionela Elisabeta Staicu"
],
"case_amount": 5,
"doi": "10.12865/CHSJ.47.01.19",
"journal": "Curr Health Sci J",
"journal_detail": "2021 Jan-Mar;47(1):117-122.",
"keywords": [
"medication-related osteonecrosis of the jaw (mronj)",
"mandibulectomy reconstruction",
"remote pectoralis major flap",
"zoledronic acid"
],
"license": "CC BY-NC-SA",
"link": "https://pubmed.ncbi.nlm.nih.gov/34211758/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC8200619",
"pmid": "34211758",
"title": "Mandibulectomy Reconstruction with Pectoralis Major Island Flap Associated with Primary Reconstruction Plate for Mandibular Medication-Related Osteonecrosis",
"year": "2021"
}
|
PMC8200619
|
A bimaxillary edentulous male patient, aged 67 years, diagnosed with prostate cancer who underwent intravenous bisphosphonates treatment (zoledronic acid) for about one year presented with pain in the anterior mandibular arch, with exposed necrotic bone, and was diagnosed with stage 2 medication-related osteonecrosis of the jaw (MRONJ). MRONJ is the development of bone necrosis in the oral cavity as an adverse reaction in patients treated with antiresorptive and antiangiogenic medication, without radiation therapy to the head and neck. This persistent bone necrosis does not always respond to standard treatments. The reconstruction technique with pectoralis major flap, at a distance, associated with the primary reconstruction plate, was an effective treatment modality for the treatment of large osteonecrosis noncompliant with conservatory treatments. Through this technique, the morpho-functionality of the jaw can be restored almost completely.
|
{
"authors": [
"Akira Miyake",
"Heima Sakaguchi",
"Aya Miyazaki",
"Takekazu Miyoshi",
"Takeshi Aiba",
"Isao Shiraishi"
],
"case_amount": 2,
"doi": "10.1016/j.hrcr.2016.09.001",
"journal": "HeartRhythm Case Rep",
"journal_detail": "2016 Sep 21;3(1):53-57.",
"keywords": [
"congenital long qt syndrome",
"fetal magnetocardiography",
"prenatal management",
"ventricular arrhythmia",
"ventricular tachycardia/torsades de pointes"
],
"license": "CC BY-NC-ND",
"link": "https://pubmed.ncbi.nlm.nih.gov/28491768/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC5420015",
"pmid": "28491768",
"title": "Successful prenatal management of ventricular tachycardia and second-degree atrioventricular block in fetal long QT syndrome",
"year": "2016"
}
|
PMC5420015
| null |
{
"authors": [
"A Shreenivasa",
"K A Vishak",
"K Sindhu",
"Kauslya Sahu",
"G V Chaithra"
],
"case_amount": 1,
"doi": "10.1155/2018/8159896",
"journal": "Case Rep Infect Dis",
"journal_detail": "2018 Nov 27;2018:8159896.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/30598849/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC6288572",
"pmid": "30598849",
"title": "Massive Haemoptysis due to Obscure Aetiology: Perils and Management Dilemmas",
"year": "2018"
}
|
PMC6288572
|
Pulmonary actinomycosis is an important differential diagnosis in patients with long-standing pulmonary infiltrates related to poor oral hygiene or compromised immune function. Up to a quarter of cases of thoracic actinomycosis are misdiagnosed as lung malignancy. Here, we report a 56-year-old man with a hypodense lesion in the left lower lobe presenting with recurrent massive haemoptysis for about one year. He underwent left lower lobe lobectomy due to intractable haemoptysis. Histopathological examination demonstrated actinomycosis infiltrating the left lower lobe. Rarity of the case was the presence of actinomycosis in an immunocompetent individual and without underlying preexisting lung disease. Also, intractable massive haemoptysis necessitating surgical excision which proved to be both diagnostic and curative due to actinomycosis is an unusual occurrence.
|
{
"authors": [
"Satoshi Kodama",
"Yuichiro Shirota",
"Akifumi Hagiwara",
"Juuri Otsuka",
"Kazuya Sato",
"Yusuke Sugiyama",
"Harushi Mori",
"Masako Watanabe",
"Masashi Hamada",
"Tatsushi Toda"
],
"case_amount": 1,
"doi": "10.1016/j.cnp.2019.05.003",
"journal": "Clin Neurophysiol Pract",
"journal_detail": "2019 Jul 16;4:164-167.",
"keywords": [
"brain tumor",
"dnet, dysembryoplastic neuroepithelial tumor",
"eeg, electroencephalogram",
"fdg-pet, 18 fluoro-2-deoxyglucose positron emission tomography",
"flair, fluid-attenuated inversion recovery",
"long-term video electroencephalogram",
"mri, magnetic resonance imaging",
"mvnt, multinodular and vacuolating neuronal tumor",
"magnetic resonance imaging (mri)",
"post-encephalitis epilepsy",
"t2wi, t2-weighted image",
"veeg, long-term video electroencephalogram"
],
"license": "CC BY-NC-ND",
"link": "https://pubmed.ncbi.nlm.nih.gov/31886439/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC6921157",
"pmid": "31886439",
"title": "Multinodular and vacuolating neuronal tumor (MVNT): A presumably incidental and asymptomatic case in an intractable epilepsy patient",
"year": "2019"
}
|
PMC6921157
|
Introduction:
Multinodular and vacuolating neuronal tumor (MVNT) had been initially described as an epilepsy-related brain tumor, but recent studies demonstrated it could be found incidentally in non-epilepsy patients.
Case report:
A 33-year-old woman with intractable post-encephalitis epilepsy presented a cluster of multinodular T2 hyperintensity in the left temporal lobe, which was very similar to the characteristics of MVNT. Long-term video electroencephalogram demonstrated that the habitual seizures were originated from bilateral temporal area and the interictal epileptic discharges were seen multifocally, although the lesions with MVNT appearance were localized in the left temporal lobe. It was presumed that the epilepsy in this patient was due to encephalitis in the past, and the link between the lesions and the epilepsy in this patient seemed weak.
Conclusion:
Although MVNT had been considered as an epilepsy-related brain tumor, we suggest it is not necessarily preferable to perform surgical resection of MVNT even on patients with epilepsy, unless epileptic foci are highly related to MVNT.
|
{
"authors": [
"Morten H Christiansen",
"Nick Chater"
],
"case_amount": 1,
"doi": "10.3389/fpsyg.2015.01182",
"journal": "Front Psychol",
"journal_detail": "2015 Aug 27;6:1182.",
"keywords": [
"cultural evolution",
"domain-general processes",
"language evolution",
"language faculty",
"recursion",
"sequence learning",
"usage-based processing"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/26379567/",
"major_mesh_terms": [],
"mesh_terms": [
"Review"
],
"pmcid": "PMC4550780",
"pmid": "26379567",
"title": "The language faculty that wasn't: a usage-based account of natural language recursion",
"year": "2015"
}
|
PMC4550780
|
In the generative tradition, the language faculty has been shrinking-perhaps to include only the mechanism of recursion. This paper argues that even this view of the language faculty is too expansive. We first argue that a language faculty is difficult to reconcile with evolutionary considerations. We then focus on recursion as a detailed case study, arguing that our ability to process recursive structure does not rely on recursion as a property of the grammar, but instead emerges gradually by piggybacking on domain-general sequence learning abilities. Evidence from genetics, comparative work on non-human primates, and cognitive neuroscience suggests that humans have evolved complex sequence learning skills, which were subsequently pressed into service to accommodate language. Constraints on sequence learning therefore have played an important role in shaping the cultural evolution of linguistic structure, including our limited abilities for processing recursive structure. Finally, we re-evaluate some of the key considerations that have often been taken to require the postulation of a language faculty.
|
{
"authors": [
"Kevin M Trapani",
"Leigh J Boghossian",
"Elizabeth Caskey"
],
"case_amount": 1,
"doi": "10.1155/2018/6031510",
"journal": "Case Rep Infect Dis",
"journal_detail": "2018 May 22;2018:6031510.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/29951328/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC5987309",
"pmid": "29951328",
"title": "Clostridium subterminale Septicemia in a Patient with Metastatic Gastrointestinal Adenocarcinoma",
"year": "2018"
}
|
PMC5987309
|
Clostridium subterminale is a rare member of the Clostridiaceae family that is rarely cultured. This report examines a case of Clostridium subterminale cultured from the blood of a 72-year-old man who was ultimately diagnosed with metastatic gastrointestinal (GI) adenocarcinoma. The patient was receiving treatment for nosocomial pneumonia prior to culture of the C. subterminale, which led to suspicion for malignancy. Extensive GI and oncologic workup demonstrated multiple comorbidities and a primary GI cancer, which likely caused a breach in the GI mucosa and C. subterminale entrance into the bloodstream. After a prolonged intensive care unit (ICU) stay, the patient died on hospital day 23. Though rarely reported, C. subterminale septicemia has been demonstrated in patients with malignancy, specifically of the GI tract. Therefore, this case represents a typical C. subterminale septicemia patient. Given the prevalence of Clostridia and the contemporary emergence of multidrug resistant (MDR) microorganisms, both typical and atypical cases regarding rare members of the species have a significant role in the clinical management and public health planning.
|
{
"authors": [
"Sylvia Biso",
"Rapeepat Lekkham",
"Antoinette Climaco"
],
"case_amount": 1,
"doi": "10.1155/2017/7134586",
"journal": "Case Rep Cardiol",
"journal_detail": "2017;2017:7134586.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/28316844/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC5337835",
"pmid": "28316844",
"title": "Aspergillus Pericarditis with Tamponade in a Renal Transplant Patient",
"year": "2017"
}
|
PMC5337835
|
Aspergillus pericarditis is a rare and life-threatening infection in immunosuppressed patients. It has nonspecific clinical manifestations that often mimic other disease entities especially in patients who have extensive comorbidities. Diagnosis is oftentimes delayed and rarely done antemortem. A high degree of suspicion in immunocompromised patients is necessary for evaluation and timely diagnosis. This is a case of Aspergillus pericarditis with cardiac tamponade in a renal transplant patient with liver cirrhosis. Two months after transplant, he developed decompensation of his cirrhosis from hepatitis C, acute cellular rejection, and Kluyvera bacteremia, followed by vancomycin-resistant Enterococcus faecium (VRE) bacteremia. Four months after transplant, the patient presented with lethargy and fluid overload. He subsequently developed shock and ventilator-dependent respiratory failure. An echocardiogram showed pericardial effusion with cardiac tamponade. He had emergent pericardiocentesis that showed purulent drainage. He was started on broad-spectrum antibiotics. Amphotericin B was initiated when the pericardial fluid grew mold that was later identified as Aspergillus fumigatus. The patient quickly decompensated and expired.
|
{
"authors": [
"Taryn A Eubank",
"Constance M Mobley",
"Mozhgon Moaddab",
"Mark J Hobeika",
"Melissa O'Neal",
"William L Musick",
"Joshua M Knight",
"Joseph S Galati",
"Sudha Kodali",
"Akshay Shetty",
"David W Victor 3rd",
"Ashish Saharia",
"R Mark Ghobrial",
"Kevin A Grimes"
],
"case_amount": 3,
"doi": "10.1155/2021/8667589",
"journal": "Case Rep Transplant",
"journal_detail": "2021 Dec 6;2021:8667589.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/34912585/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC8668347",
"pmid": "34912585",
"title": "Successful Treatment of Invasive Mucormycosis in Orthotopic Liver Transplant Population",
"year": "2021"
}
|
PMC8668347
|
Mucormycosis is caused by ubiquitous fungi and encompasses a variety of different opportunistic syndromes in humans that disproportionately affect immunocompromised patients. Mortality has been documented to range between 50 and 100%; however, location of infection greatly dictates likelihood of survival. Treatment of mucormycosis involves aggressive surgical intervention and combination therapy of antifungal agents. In solid organ transplant recipients, immunosuppressive agents used to prevent rejection of the transplanted organ pose additional obstacles in the treatment of invasive fungal infections. We report on 3 high models for end-stage liver disease (MELD-Na) score orthotopic liver transplant (OLT) recipients who all were diagnosed with Rhizopus spp. infections with positive, 1-year outcomes after aggressive, individualized treatment.
|
{
"authors": [
"Abdul Rehman Arain",
"Muhammad Moral",
"Saadia Shams",
"Khusboo Desai",
"Khunwar Kalsa"
],
"case_amount": 1,
"doi": "10.1155/2019/4037916",
"journal": "Case Rep Orthop",
"journal_detail": "2019 May 20;2019:4037916.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/31236299/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC6545747",
"pmid": "31236299",
"title": "Atypical Presentation of Atraumatic Spinal Subdural Hematoma Associated with Warfarin: A Case Report and Review of the Literature",
"year": "2019"
}
|
PMC6545747
|
Nontraumatic spinal subdural hematomas secondary to anticoagulants are remarkably rare. A case of spontaneous, atraumatic subdural hematoma involving the thoracic region in an 80-year-old woman on warfarin is reported. The patient presented with gross motor and sensory loss, delayed onset of incontinence, and no other symptoms. An MRI suggested an epidural hematoma concentrated around the T4-T9 levels. She was taken emergently to the OR approximately 30 hours after the initial onset of symptoms for a T3-T11 laminectomy. No epidural hematoma was noted. However, discoloration and bulging of the thecal sac were noted, and the dura was incised longitudinally from T2 to T10 revealing an expansive jelly-like blood clot which was evacuated. Postoperatively, the patient had regained 1/2 sensory function in the bilateral lower extremities. At the 2-week mark, the patient was still incontinent and showed 2/2 sensory and 2/5 motor functions in select muscle groups in her bilateral lower extremities. Completely nontraumatic, spontaneous subdural hematomas of the spine are very rare, and early surgical decompression within 24 hours from symptom onset may allow neurological recovery. Large extensive laminectomies up to 10 thoracic levels have been shown to be safe and effective in a few cases, including our case.
|
{
"authors": [
"Teppei Tanaka",
"Motoharu Hayakawa",
"Akiyo Sadato",
"Kazuhide Adachi",
"Takeya Watabe",
"Shingo Maeda",
"Masahiro Ohmura",
"Yuichi Hirose"
],
"case_amount": 1,
"doi": "10.2176/nmc.cr.2013-0007",
"journal": "Neurol Med Chir (Tokyo)",
"journal_detail": "2014;54(2):155-60.",
"keywords": null,
"license": "CC BY-NC-ND",
"link": "https://pubmed.ncbi.nlm.nih.gov/24418783/",
"major_mesh_terms": [
"Arteriovenous Fistula / therapy",
"Carotid Artery, Internal / pathology",
"Cavernous Sinus / pathology",
"Ehlers-Danlos Syndrome / complications",
"Embolization, Therapeutic / methods",
"Endovascular Procedures / methods",
"Intracranial Arteriovenous Malformations / therapy"
],
"mesh_terms": [
"Arteriovenous Fistula / therapy",
"Carotid Artery, Internal / pathology",
"Cavernous Sinus / pathology",
"Ehlers-Danlos Syndrome / complications",
"Embolization, Therapeutic / methods",
"Endovascular Procedures / methods",
"Intracranial Arteriovenous Malformations / therapy",
"Case Reports",
"Adult",
"Angiography, Digital Subtraction",
"Aphasia / etiology",
"Arteriovenous Fistula / etiology",
"Cerebral Angiography",
"Cerebral Veins",
"Female",
"Humans",
"Intracranial Arteriovenous Malformations / etiology",
"Tinnitus / etiology"
],
"pmcid": "PMC4508704",
"pmid": "24418783",
"title": "Transvenous embolization for carotid-cavernous fistula in a patient with vascular type of Ehlers-Danlos syndrome--direct superior ophthalmic vein approach: case report",
"year": "2014"
}
|
PMC4508704
|
The vascular type of Ehlers-Danlos syndrome (vEDS) is an autosomal dominant hereditary disease characterized by connective tissue fragility throughout the body, including the arteries, viscera, and gastrointestinal tract. We report a case in which we performed transvenous embolization (TVE) via direct superior ophthalmic vein (SOV) approach to treat a direct carotid-cavernous fistula (CCF) in a patient with Ehlers-Danlos syndrome (EDS). The patient was a 37-year-old woman who developed tinnitus in her left ear and a headache during examination in the outpatient clinic of another hospital in order to make a definitive diagnosis of vEDS, and she was referred to our hospital and examined. Based on the results of all of the studies she was diagnosed with a CCF. Conservative treatment was attempted, but was not very effective. Because of progressing aphasia, TVE was performed via the SOV direct cut. There were no intraoperative or postoperative complications. It has been reported that cerebral angiography is generally contraindicated in vEDS and that the morbimortality associated with endovascular treatment is very high. When performing treatment it is necessary to be sufficiently aware of the risks it entails.
|
{
"authors": [
"Timothy R Larsen",
"Dritan Dragu",
"Michael Williams"
],
"case_amount": 1,
"doi": "10.1155/2013/709474",
"journal": "Case Rep Med",
"journal_detail": "2013;2013:709474.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/23935638/",
"major_mesh_terms": [],
"mesh_terms": [],
"pmcid": "PMC3722985",
"pmid": "23935638",
"title": "Wernicke's Encephalopathy: An Unusual Consequence of the Acquired Immune Deficiency Syndrome-Case Report and Literature Review",
"year": "2013"
}
|
PMC3722985
|
Introduction. Wernicke's encephalopathy is a well-described syndrome characterized by the classic triad of confusion, ataxia, and ophthalmoplegia. Wernicke's encephalopathy results from thiamine (vitamin B1) deficiency. Common causes include alcoholism and gastric disorders. Wernicke's has been described in patients with acquired immune deficiency syndrome (AIDS); however, given these patients' immunosuppressed state, the diagnosis of Wernicke's encephalopathy is not apparent. Case Presentation. A 31-year-old previously healthy male presented to the ER complaining of progressive dyspnea. Workup revealed HIV/AIDS and PCP pneumonia. He was treated and improved. On day 14 he became confused and developed nystagmus and ataxia. Considering his immunocompromised state, infectious and neoplastic etiologies topped the differential diagnosis. CT head was negative. Lumbar puncture was unremarkable. Brain MRI revealed increased T2 signal in the medial thalamus bilaterally. Intravenous thiamine was administered resulting in resolution of symptoms. Discussion. The classic triad of Wernicke's encephalopathy occurs in 10% of cases. When immunosuppressed patients develop acute neurologic symptoms infectious or neoplastic etiologies must be excluded. However, given the relative safety of thiamine supplementation, there should be a low threshold for initiating therapy in order to reverse the symptoms and prevent progression to Korsakoff dementia, which is permanent.
|
{
"authors": [
"Joanna Kosałka-Węgiel",
"Mamert Milewski",
"Andżelika Siwiec",
"Magdalena Strach",
"Bogdan Ochrem",
"Mariusz Korkosz"
],
"case_amount": 1,
"doi": "10.5114/ceji.2021.108259",
"journal": "Cent Eur J Immunol",
"journal_detail": "2021;46(3):395-397.",
"keywords": [
"hes",
"il-5",
"il-5 receptor",
"benralizumab",
"hypereosinophilic syndrome",
"monoclonal antibody"
],
"license": "CC BY-NC-SA",
"link": "https://pubmed.ncbi.nlm.nih.gov/34764813/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC8574116",
"pmid": "34764813",
"title": "Severe hypereosinophilic syndrome successfully treated with a monoclonal antibody against interleukin 5 receptor α - benralizumab",
"year": "2021"
}
|
PMC8574116
|
Hypereosinophilic syndrome (HES) is a group of a rare diseases characterized by marked eosinophilia in blood or tissue and eosinophil-related clinical manifestations. Benralizumab is a humanized, monoclonal antibody against interleukin 5 (IL-5) receptor α, which is expressed on human eosinophils. Here, we present the case of a patient with severe HES in whom treatment with benralizumab, an anti-IL-5 receptor monoclonal antibody, was initiated 6 months ago. Prior to benralizumab administration, the patient was treated with glucocorticoids (GS) and mepolizumab. However, instead of the applied treatment and normal level of peripheral eosinophils the patient presented with fluctuating lower respiratory tract symptoms and recurrent exacerbations of HES. Treatment with benralizumab (30 mg s.c. every 4-6 weeks) was started, resulting in significant improvement of respiratory signs and symptoms, normalization of eosinophil count and significant reduction of the methylprednisolone dose (after 5 doses of benralizumab administration). No substantial side effects have been noted during treatment and 6-month follow-up. We argue that in the severe and relapsing course of HES, rescue treatment with benralizumab should be taken into account, particularly in cases of relative inefficacy of GS and mepolizumab.
|
{
"authors": [
"Guoli Ren",
"Bo Wang",
"Daliang Liu"
],
"case_amount": 1,
"doi": "10.1177/20584601231152640",
"journal": "Acta Radiol Open",
"journal_detail": "2023 Jan 20;12(1):20584601231152640.",
"keywords": [
"cta",
"horseshoe lung",
"adults",
"pulmonary sequestration"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/36699098/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC9869191",
"pmid": "36699098",
"title": "Adult congenital horseshoe lung with bilateral pulmonary sequestration: A case report",
"year": "2023"
}
|
PMC9869191
|
Horseshoe lung (HL) is an infrequent congenital lung anomaly. Its main feature is that the lower lungs on both sides extend behind the pericardium and fuse across the midline, usually accompanied by pulmonary dysplasia. It is reported that 80% of HL is relevant to the abnormal return of some pulmonary veins from the right lung to the inferior vena cava or right atrium (scimitar syndrome). Most patients are within 5 years old, most commonly within 1 year old, but HL may also have no apparent clinical symptoms or mild symptoms. This case is a 36-years-old adult female who developed left chest pain more than a month ago and continued to worsen for 10 days. The patient also had repeated pulmonary infection with cough and expectoration.
|
{
"authors": [
"A Katz",
"P Zalewski"
],
"case_amount": 1,
"doi": "10.1038/sj.bjc.6601478",
"journal": "Br J Cancer",
"journal_detail": "2003 Dec;89 Suppl 2(Suppl 2):S15-8.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/14661048/",
"major_mesh_terms": [
"Antineoplastic Agents / therapeutic use",
"Brain Neoplasms / drug therapy",
"Carcinoma, Non-Small-Cell Lung / drug therapy",
"Lung Neoplasms / drug therapy",
"Neoplasm Recurrence, Local / drug therapy",
"Quinazolines / therapeutic use"
],
"mesh_terms": [
"Antineoplastic Agents / therapeutic use",
"Brain Neoplasms / drug therapy",
"Carcinoma, Non-Small-Cell Lung / drug therapy",
"Lung Neoplasms / drug therapy",
"Neoplasm Recurrence, Local / drug therapy",
"Quinazolines / therapeutic use",
"Review",
"Brain Neoplasms / secondary",
"Carcinoma, Non-Small-Cell Lung / secondary",
"Gefitinib",
"Humans",
"Lung Neoplasms / pathology",
"Quality of Life",
"Antineoplastic Agents",
"Quinazolines",
"Gefitinib"
],
"pmcid": "PMC2750244",
"pmid": "14661048",
"title": "Quality-of-life benefits and evidence of antitumour activity for patients with brain metastases treated with gefitinib",
"year": "2003"
}
|
PMC2750244
|
Brain metastases are a common complication of non-small-cell lung cancer (NSCLC). The role of chemotherapy in the treatment of brain metastases has not been clearly defined. Emerging case reports of patients with recurrent NSCLC treated as part of the Expanded Access Programme reveal that gefitinib ("Iressa", ZD1839) has clinical activity in some patients with brain metastases. Here, we describe a number of case studies documenting the response of patients with brain metastases to treatment with gefitinib. Many of these patients had quality-of-life benefits with improvement of neurological and systemic symptoms; some had a partial response of their brain metastases and even complete responses have been seen in a few patients. One case report also describes a durable long-term response with concurrent treatment with gefitinib and radiotherapy. Such results call for larger trials designed to evaluate and define the role of gefitinib in the treatment of brain metastases in NSCLC patients, either as a single agent or in combination with radiation therapy.
|
{
"authors": [
"Toshinobu Yokoyama",
"Masashi Hirokawa",
"Yutaka Imamura",
"Hisamichi Aizawa"
],
"case_amount": 1,
"doi": "10.2147/idr.s8647",
"journal": "Infect Drug Resist",
"journal_detail": "2010;3:1-4.",
"keywords": [
"hiv",
"agranulocytosis",
"amebiasis",
"amoebic empyema",
"trimethoprim-sulfamethoxazole"
],
"license": "NO-CC CODE",
"link": "https://pubmed.ncbi.nlm.nih.gov/21694888/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC3108731",
"pmid": "21694888",
"title": "Respiratory failure caused by intrathoracic amoebiasis",
"year": "2010"
}
|
PMC3108731
|
A 41-year-old male was admitted to the hospital with symptoms of diarrhea, fever and rapidly progressive respiratory distress. A chest radiograph and computed tomography (CT) of the chest and the abdomen showed a large amount of right pleural effusion and a large liver abscess. The patient was thus diagnosed to have amoebic colitis, amoebic liver abscess and amoebic empyema complicated with an HIV infection. The patient demonstrated agranulocytosis caused by the administration of trimethoprim-sulfamethoxazole. However, the administration of granulocyte colony-stimulating factor made it possible for the patient to successfully recover from agranulocytosis, and he thereafter demonstrated a good clinical course.
|
{
"authors": [
"Satoko Kako",
"Satoru Joshita",
"Akemi Matsuo",
"Kenji Kawaguchi",
"Takeji Umemura",
"Eiji Tanaka"
],
"case_amount": 1,
"doi": "10.1155/2019/8357893",
"journal": "Case Rep Oncol Med",
"journal_detail": "2019 Feb 17;2019:8357893.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/30911425/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC6398058",
"pmid": "30911425",
"title": "A Case of Adult T-Cell Leukemia/Lymphoma Complicated with Bilateral Chylothorax",
"year": "2019"
}
|
PMC6398058
|
We present the case of a 74-year-old Japanese woman who presented with dyspnea, a palpable right breast mass, and swollen right axillary lymph node. Imaging studies revealed bilateral pleural effusion and systemic lymph adenopathy and pleural fluid study showed high levels of triglycerides. A right inguinal lymph node biopsy disclosed malignant lymphoma cells that were human T-cell leukemia virus type 1 (HTLV-1) provirus DNA-positive, a condition endemic to patient's birthplace, by the Southern blot hybridization method. She was diagnosed as having adult T-cell leukemia/lymphoma (ATL) with chylothorax. After commencing chemotherapy for ATL, her chylothorax disappeared and swollen lymph nodes reduced remarkably, indicating an association between the chylothorax and ATL. Bilateral chylothorax is a relatively rare condition associated with such nontraumatic causes as ATL. Clinicians should therefore bear chylothorax in mind when encountering patients with pleural effusion. A detailed medical history can also enable prompt diagnosis and appropriate treatment.
|
{
"authors": [
"Emilio de León Castorena",
"Miriam Daniela de León Castorena"
],
"case_amount": 1,
"doi": "10.1177/2050313X19849837",
"journal": "SAGE Open Med Case Rep",
"journal_detail": "2019 May 14;7:2050313X19849837.",
"keywords": [
"intestinal stones",
"enterolithiasis",
"mechanical intestinal obstruction",
"small bowel obstruction",
"stricture",
"ulcerative colitis"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/31205711/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC6537081",
"pmid": "31205711",
"title": "Intestinal stones: A rare cause of bowel obstruction",
"year": "2019"
}
|
PMC6537081
|
Enterolithiasis or intestinal stones are uncommonly reported. Enterostasis is the cause of stone formation mainly secondary to tuberculous strictures. Although it is unusual, enteroliths can cause intestinal obstruction. We report a case of a mechanical partial intestinal obstruction in a patient with ulcerative colitis previously treated with total colectomy, with the rare diagnosis of multiple primary enterolithiasis.
|
{
"authors": [
"Hamza Dergamoun",
"Abdelaziz El Gdaouni",
"Imad Ziouziou"
],
"case_amount": 1,
"doi": "10.11604/pamj.2022.43.106.36588",
"journal": "Pan Afr Med J",
"journal_detail": "2022 Oct 27;43:106.",
"keywords": [
"renal cell carcinoma",
"case report",
"gallbladder",
"metastasis"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/36699978/",
"major_mesh_terms": [
"Carcinoma, Renal Cell / diagnosis",
"Carcinoma, Renal Cell / pathology",
"Carcinoma, Renal Cell / surgery",
"Gallbladder Neoplasms / diagnosis",
"Gallbladder Neoplasms / surgery",
"Kidney Neoplasms / diagnosis",
"Kidney Neoplasms / pathology",
"Kidney Neoplasms / surgery"
],
"mesh_terms": [
"Carcinoma, Renal Cell / diagnosis",
"Carcinoma, Renal Cell / pathology",
"Carcinoma, Renal Cell / surgery",
"Gallbladder Neoplasms / diagnosis",
"Gallbladder Neoplasms / surgery",
"Kidney Neoplasms / diagnosis",
"Kidney Neoplasms / pathology",
"Kidney Neoplasms / surgery",
"Case Reports",
"Aged, 80 and over",
"Cholecystectomy",
"Female",
"Humans"
],
"pmcid": "PMC9834804",
"pmid": "36699978",
"title": "Renal cell carcinoma with gallbladder metastasis: a case report",
"year": "2022"
}
|
PMC9834804
|
Renal cell carcinoma (RCC) is the most frequent renal neoplasm, with a high rate of metastasis, especially in the lungs and bones. The gallbladder is one of the rare metastatic sites. We report an 80-year-old woman who presented with chronic right flank pain for the last six months. A computer tomography scan revealed a heterogeneous right renal mass measuring 86 ×76× 68 mm and multi lithiasis in the gallbladder. A right radical nephrectomy, lymphadenectomy, and cholecystectomy were performed. The postoperative clinical course was uneventful, without any complications. The histological results showed a clear RCC with metastasis to the gallbladder. After 12-months follow-up, the patient is free from disease. In conclusion, even though the coexistence of metastatic gallbladder from clear RCC is rare, the possibility of concurrence should be considered if suspected findings in the gallbladder are identified intraoperatively.
|
{
"authors": [
"Moises Enghelberg",
"Syeda Kaifee"
],
"case_amount": 1,
"doi": "10.7759/cureus.33964",
"journal": "Cureus",
"journal_detail": "2023 Jan 19;15(1):e33964.",
"keywords": [
"chemotherapy-related toxicity",
"maculopathy",
"retinal toxicity",
"tyrosine kinase receptor inhibitors",
"retina"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/36824546/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC9941022",
"pmid": "36824546",
"title": "Suspected Neratinib Macular Toxicity Presenting As Macular Telangiectasia Type II",
"year": "2023"
}
|
PMC9941022
|
The purpose of this case report is to present the first case of neratinib maculopathy. We describe the initial presentation, baseline characteristics, imaging findings, and outcomes. The case report is accompanied by a thorough literature review including possible mechanisms of tyrosine kinase inhibitor (TKI) maculopathy. Neratinib is a novel TKI that is commonly used in the treatment of breast-associated malignancies. Neratinib toxicity presents similarly to macular telangiectasia type II but differs with the fine granular hypofluorescent areas spanning the limit of the posterior pole and vascular arcades as well as the nasal aspect of the optic nerve. We report a case of suspected macular toxicity secondary to neratinib. Concomitant use of neratinib in conjunction with docetaxel and other chemotherapeutics with known retinal side effects should alert clinicians of an increase in the risk of macular toxicity. Albeit commonly reported ocular side effects of TKIs, maculopathy is a rare and potentially overlooked side effect. Patients that have planned chemotherapy should undergo a baseline retinal examination.
|
{
"authors": [
"Nikhil Gupta",
"Umesh Bansal",
"Neha Mahajan",
"Maha Singh Yadav"
],
"case_amount": 1,
"doi": "10.4081/cp.2012.e9",
"journal": "Clin Pract",
"journal_detail": "2011 Dec 30;2(1):e9.",
"keywords": [
"abdominal wall metastasis",
"adrenal cortex",
"carcinoma"
],
"license": "NO-CC CODE",
"link": "https://pubmed.ncbi.nlm.nih.gov/24765408/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC3981348",
"pmid": "24765408",
"title": "Abdominal wall metastasis in scar after open resection of an adrenocortical carcinoma",
"year": "2011"
}
|
PMC3981348
|
A 42-year-old man patient presented with progressively increasing, occasionally painful lump in the left upper and central abdomen. Investigations revealed well-defined capsulated left adrenocortical carcinoma. Tumor was resected successfully along with left kidney. Tumor recurred in the abdominal surgical scar 1.5 years after surgery. We are reporting this case because of rarity of metastatic recurrence of an adrenocortical carcinoma in the abdominal surgical scar 1.5 years after resection of primary tumor.
|
{
"authors": [
"Rajnish Kalra",
"Richa Pawar",
"Sonia Hasija",
"Abha Chandna",
"Manoj Sankla",
"Chanchal Malhotra"
],
"case_amount": 1,
"doi": "10.4103/0970-9371.197623",
"journal": "J Cytol",
"journal_detail": "2017 Jan-Mar;34(1):59-61.",
"keywords": [
"frontal bone",
"occult follicular thyroid carcinoma",
"skull metastasis"
],
"license": "CC BY-NC-SA",
"link": "https://pubmed.ncbi.nlm.nih.gov/28182063/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC5259936",
"pmid": "28182063",
"title": "Frontal bone metastasis from an occult follicular thyroid carcinoma: Diagnosed by FNAC",
"year": "2017"
}
|
PMC5259936
|
Metastatic deposits in skull bones from follicular thyroid carcinoma is rare, and metastatic disease in skull being the presenting symptom without obvious thyroid lesion (occult primary) is even rarer. A 60-year-old female patient presented with a mass in the frontal region of the skull. Fine needle aspiration cytology was done which revealed an adenocarcinoma with repeated follicular pattern, reminiscent of follicular neoplasm of thyroid, which on immunocytochemistry revealed positivity for thyroglobulin. Patient was investigated further for primary thyroid malignancy, and imaging revealed a nodule in the left lobe of thyroid. Neuroimaging showed osteolytic lesion involving the cranium.
|
{
"authors": [
"Cindy Y G Noben",
"Frans J N Nijhuis",
"Angelique E de Rijk",
"Silvia M A A Evers"
],
"case_amount": 1,
"doi": "10.1186/1471-2458-12-43",
"journal": "BMC Public Health",
"journal_detail": "2012 Jan 18;12:43.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/22257557/",
"major_mesh_terms": [
"Disabled Persons",
"Occupational Health Services / economics",
"Rehabilitation, Vocational / economics",
"Sick Leave / economics"
],
"mesh_terms": [
"Disabled Persons",
"Occupational Health Services / economics",
"Rehabilitation, Vocational / economics",
"Sick Leave / economics",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't",
"Adolescent",
"Adult",
"Cost-Benefit Analysis",
"Follow-Up Studies",
"Humans",
"Middle Aged",
"Netherlands",
"Occupational Health Services / methods",
"Outcome Assessment, Health Care",
"Rehabilitation, Vocational / methods",
"Research Design",
"Risk",
"Sick Leave / statistics & numerical data",
"Young Adult"
],
"pmcid": "PMC3273437",
"pmid": "22257557",
"title": "Design of a trial-based economic evaluation on the cost-effectiveness of employability interventions among work disabled employees or employees at risk of work disability: the CASE-study",
"year": "2012"
}
|
PMC3273437
|
Background:
In the Netherlands, absenteeism and reduced productivity due to work disability lead to high yearly costs reaching almost 5% of the gross national product. To reduce the economic burden of sick leave and reduced productivity, different employability interventions for work-disabled employees or employees at risk of work disability have been developed. Within this study, called 'CASE-study' (Cost-effectiveness Analysis of Sustainable Employability), five different employability interventions directed at work disabled employees with divergent health complaints will be analysed on their effectiveness and cost-effectiveness. This paper describes a consistent and transparent methodological design to do so.
Methods/design:
Per employability intervention 142 participants are needed whereof approximately 66 participants receiving the intervention will be compared with 66 participants receiving usual care. Based on the intervention-specific characteristics, a randomized control trial or a quasi-experiment with match-criteria will be conducted. Notwithstanding the study design, eligible participants will be employees aged 18 to 63, working at least 12 h per week, and at risk of work disability, or already work-disabled due to medical restrictions. The primary outcome will be the duration of sick leave. Secondary outcomes are health status and quality of life. Outcomes will be assessed at baseline and then 6, 12 and 18 months later. Economic costs will consist of healthcare costs and cost of lost production due to work disability, and will be evaluated from a societal perspective.
Discussion:
The CASE-study is the first to conduct economic evaluations of multiple different employability interventions based on a similar methodological framework. The cost-effectiveness results for every employability intervention will be published in 2014, but the methods, strengths and weaknesses of the study protocol are discussed in this paper. To contribute to treatment options in occupational health practice and enable the development of guidelines on how to conduct economic evaluation better suited to this field; this paper provides an important first step.
Trial registration:
Four trials involved in the CASE-study are registered with the Netherlands Trial Registry: Care for Work (NTR2886), Health and Motion (NTR3111), Guidance to Excel in Return to Work (NTR3151), Care for Companies/Second Care (NTR3136).
|
{
"authors": [
"Mariana Leuzinger-Dias",
"Mário Lima-Fontes",
"Rita Rodrigues",
"Cláudia Oliveira-Ferreira",
"Carolina Madeira",
"Fernando Falcão-Reis",
"Vítor Fernandes",
"Amândio Rocha-Sousa",
"Manuel Falcão"
],
"case_amount": 1,
"doi": "10.1155/2021/9349323",
"journal": "J Ophthalmol",
"journal_detail": "2021 Dec 20;2021:9349323.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/34966559/",
"major_mesh_terms": [],
"mesh_terms": [],
"pmcid": "PMC8712131",
"pmid": "34966559",
"title": "Scleral Fixation of Akreos AO60 Intraocular Lens Using Gore-Tex Suture: An Eye on Visual Outcomes and Postoperative Complications",
"year": "2021"
}
|
PMC8712131
|
Purpose:
"In-the-bag" placement of an IOL is the Holy Grail for any cataract surgeon. However, in the absence of capsular integrity, alternative surgical options to place the IOL must be sought. We aim to report the clinical outcomes and safety profile of scleral-fixated Akreos AO60 intraocular lens implantation using Gore-Tex suture, combined with pars plana vitrectomy.
Methods:
This is a single-center, retrospective case series descriptive study. Electronic clinical records of all patients subjected to scleral fixation of a Bausch and Lomb Akreos AO60 IOL combined with pars plana vitrectomy, between April 1, 2017, and August 1, 2021, were reviewed. Data concerning age, sex, laterality, past ophthalmological history, pre- and postoperative best-available visual acuity, surgical indication, and intra- and postoperative complications were collected. Measured outcomes were the differences in best-available visual acuity and frequency of postoperative complications.
Results:
A total of 37 eyes (20 right eyes and 17 left eyes) from 36 patients (16 females and 20 males) were included in the statistical analysis. The mean age at time of surgery was 72.0 ± 12.4 years. The mean follow-up period was 548.9 days (range 39-1564 days). Globally, the mean best-available logMAR visual acuity improved from 1.61 preoperatively (0.025 decimal equivalent) to 0.57 postoperatively (0.3 decimal equivalent), this difference being statistically significant (P < 0.001). Indications for surgery included aphakia due to complicated cataract surgery (24.3%; n = 9); subluxated IOL due to closed trauma (21.6%; n = 8); PEX-related subluxated IOL (16.2%; n = 6); non-traumatic, non-PEX-related subluxated IOL (18.9%; n = 7); subluxated crystalline lens due to closed trauma (8.1%; n = 3); aphakia due to open-globe injury (5.4%; n = 2); silicone-induced IOL opacification (2.7%; n = 1); and aphakia post-endophthalmitis (2.7%; n = 1). Postoperative complications included transient ocular hypertension (27.0%; n = 10), transient corneal edema (18.9%; n = 7), cystoid macular edema (18.9%, n = 7), self-limited hypotension (5.4%, n = 2), self-limited vitreous hemorrhage (2.7%, n = 1), central retinal vein occlusion (2.7%, n = 1), late retinal detachment (2.7%, n = 1), and Akreos IOL opacification (2.7%, n = 1). No suture-related complications were observed.
Conclusion:
There was a statistically significant improvement in visual acuity after scleral fixation of Akreos AO60 intraocular lens using Gore-Tex suture, with no suture-related problems recorded. This procedure seems to be a valuable alternative for posterior chamber IOL placement when secondary IOL implantation is required.
|
{
"authors": [
"Takashi Nishida",
"Takashi Ishiguro",
"Kenji Takano",
"Taisuke Isono",
"Yoichi Kobayashi",
"Yoshihiko Shimizu",
"Noboru Takayanagi"
],
"case_amount": 2,
"doi": "10.1016/j.rmcr.2019.100949",
"journal": "Respir Med Case Rep",
"journal_detail": "2019 Oct 16;28:100949.",
"keywords": [
"bronchoalveolar lavage fluid",
"hpev",
"pcr",
"viral pneumonia",
"human parechovirus"
],
"license": "CC BY-NC-ND",
"link": "https://pubmed.ncbi.nlm.nih.gov/31709139/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC6831859",
"pmid": "31709139",
"title": "Two cases of primary human parechovirus pneumonia in adults",
"year": "2019"
}
|
PMC6831859
|
Human parechoviruses (HPeV) are mainly isolated from upper respiratory tract infection and gastroenteritis in children. HPeV has not been screened for in the past studies of community-acquired pneumonia (CAP) in adults, and its association with CAP is unknown. We present two cases that HPeV was detected by multiplex polymerase chain reaction for respiratory viruses using bronchoalveolar lavage fluid and diagnosed as pneumonia caused by HPeV.
|
{
"authors": [
"Yukiko Mikami",
"Tomonori Nagai",
"Yousuke Gomi",
"Yasushi Takai",
"Masahiro Saito",
"Kazunori Baba",
"Hiroyuki Seki"
],
"case_amount": 1,
"doi": "10.1186/s13256-015-0790-6",
"journal": "J Med Case Rep",
"journal_detail": "2016 Jan 18;10:9.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/26781485/",
"major_mesh_terms": [
"Antibiotics, Antineoplastic / therapeutic use",
"Antineoplastic Agents / adverse effects",
"Chorionic Gonadotropin / blood",
"Dactinomycin / therapeutic use",
"Hydatidiform Mole, Invasive / drug therapy",
"Hysterectomy",
"Lung Neoplasms / drug therapy",
"Methotrexate / adverse effects",
"Porphyria, Acute Intermittent / complications",
"Uterine Neoplasms / drug therapy"
],
"mesh_terms": [
"Antibiotics, Antineoplastic / therapeutic use",
"Antineoplastic Agents / adverse effects",
"Chorionic Gonadotropin / blood",
"Dactinomycin / therapeutic use",
"Hydatidiform Mole, Invasive / drug therapy",
"Hysterectomy",
"Lung Neoplasms / drug therapy",
"Methotrexate / adverse effects",
"Porphyria, Acute Intermittent / complications",
"Uterine Neoplasms / drug therapy",
"Case Reports",
"Antineoplastic Agents / administration & dosage",
"Drug Eruptions / drug therapy",
"Drug Eruptions / etiology",
"Female",
"Humans",
"Hydatidiform Mole, Invasive / secondary",
"Hydatidiform Mole, Invasive / surgery",
"Lung Neoplasms / secondary",
"Methotrexate / administration & dosage",
"Middle Aged",
"Pregnancy",
"Treatment Outcome",
"Uterine Neoplasms / pathology",
"Uterine Neoplasms / surgery",
"Antibiotics, Antineoplastic",
"Antineoplastic Agents",
"Chorionic Gonadotropin",
"Dactinomycin",
"Methotrexate"
],
"pmcid": "PMC4717627",
"pmid": "26781485",
"title": "Methotrexate and actinomycin D chemotherapy in a patient with porphyria: a case report",
"year": "2016"
}
|
PMC4717627
|
Background:
Despite their broadly recommended use as chemotherapeutic agents, the porphyrogenicity of methotrexate and actinomycin D have not been confirmed. Accordingly, it is not known whether these agents are safe for use in patients with porphyria.
Case presentation:
In this report, we present a case of an invasive mole with lung metastasis in a 49-year-old Japanese woman who had previously been diagnosed with acute intermittent porphyria at 27 years of age but had no recent history of acute intermittent porphyria attacks. Her serum human chorionic gonadotropin level was elevated 1 month after hysterectomy, and she was referred to our center for chemotherapy. After she received 100 mg of methotrexate, drug eruptions were observed starting on day 3 and grew progressively worse. Erythema and mucosal erosion spread throughout her body, whereupon she was administered prednisolone. In addition, our patient experienced febrile neutropenia and required granulocyte colony- stimulating factor treatment. No changes in our patient's urinary coproporphyrin or uroporphyrin levels were detected during this entire episode. Methotrexate was replaced by actinomycin D (0.5 mg/body intravenously on days 1-5 every 2 weeks). After five uneventful cycles of actinomycin D, our patient achieved and maintained a normal serum human chorionic gonadotropin level for 3 years.
Conclusions:
Methotrexate and actinomycin D did not induce acute porphyric attacks in this patient with acute intermittent porphyria; however, severe adverse effects were noted with methotrexate. Although further investigation is required, our data suggest that these agents are nonporphyrinogenic and can therefore be used to treat patients with comorbid porphyria.
|
{
"authors": [
"Bartosz Hudzik",
"Lech Poloński",
"Mariusz Gąsior"
],
"case_amount": 1,
"doi": "10.1007/s11739-015-1384-4",
"journal": "Intern Emerg Med",
"journal_detail": "2016 Dec;11(8):1139-1140.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/26758273/",
"major_mesh_terms": [
"Electrocardiography / standards",
"Tricuspid Valve Insufficiency / complications",
"Tricuspid Valve Insufficiency / surgery"
],
"mesh_terms": [
"Electrocardiography / standards",
"Tricuspid Valve Insufficiency / complications",
"Tricuspid Valve Insufficiency / surgery",
"Case Reports",
"Aged",
"Female",
"Humans",
"Jugular Veins / abnormalities",
"Tricuspid Valve Insufficiency / diagnostic imaging"
],
"pmcid": "PMC5114320",
"pmid": "26758273",
"title": "Lancisi sign: giant C-V waves of tricuspid regurgitation",
"year": "2016"
}
|
PMC5114320
| null |
{
"authors": [
"Mir Sadaqat Hassan Zafar",
"M Mubarik Naqash",
"Tariq A Bhat",
"G M Malik"
],
"case_amount": 1,
"doi": "10.4103/2249-4863.109965",
"journal": "J Family Med Prim Care",
"journal_detail": "2013 Jan;2(1):90-1.",
"keywords": [
"gbs",
"immunomodulating therapy",
"post-partum period",
"pregnancy"
],
"license": "CC BY-NC-SA",
"link": "https://pubmed.ncbi.nlm.nih.gov/24479054/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC3894025",
"pmid": "24479054",
"title": "Guillain-barré syndrome in pregnancy: an unusual case",
"year": "2013"
}
|
PMC3894025
|
Guillain-Barré syndrome (GBS) is rare in pregnancy with an estimated incidence between 1.2 and 1.9 cases per 100,000 people annually, and it carries a high maternal risk. We report a 29-year-old primigravida who had pain and progressive heaviness of both lower limbs in her third trimester of pregnancy. The attending gynecologist ascribed these symptoms to ongoing pregnancy. The intrapartum period (lower segment caesarian section) passed uneventfully. On third postpartum day, the patient developed weakness of all the four limbs. A detailed history and physical examination pointed toward GBS although there was no antecedent infective episode. Subsequent nerve conduction velocity studies and cerebrospinal fluid analysis confirmed GBS. All other investigations including electrolytes were normal. The patient improved without the introduction of immunomodulating therapy.
|
{
"authors": [
"Tadashi Nukaga",
"Akihiko Hiyama",
"Hiroyuki Katoh",
"Masahiko Watanabe"
],
"case_amount": 2,
"doi": "10.22603/ssrr.2018-0053",
"journal": "Spine Surg Relat Res",
"journal_detail": "2018 Nov 20;3(4):396-400.",
"keywords": [
"turner syndrome",
"aneurysmal bone cysts",
"expandable cage",
"intraoperative navigation",
"preoperative embolization"
],
"license": "CC BY-NC-ND",
"link": "https://pubmed.ncbi.nlm.nih.gov/31768462/",
"major_mesh_terms": [],
"mesh_terms": [],
"pmcid": "PMC6834456",
"pmid": "31768462",
"title": "Aneurysmal Bone Cyst of the Lumbar Spine in a Patient with Turner Syndrome: A Case Report",
"year": "2018"
}
|
PMC6834456
| null |
{
"authors": [
"Abdelhakim Kherfani",
"Hachem Mahjoub"
],
"case_amount": 1,
"doi": "10.11604/pamj.2014.18.251.4661",
"journal": "Pan Afr Med J",
"journal_detail": "2014 Jul 26;18:251.",
"keywords": [
"ct",
"mri",
"melorheostosis",
"sclerotic bone dysplasias"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/25489356/",
"major_mesh_terms": [
"Melorheostosis / diagnosis",
"Rare Diseases / diagnosis"
],
"mesh_terms": [
"Melorheostosis / diagnosis",
"Rare Diseases / diagnosis",
"Case Reports",
"Adult",
"Anti-Inflammatory Agents, Non-Steroidal / therapeutic use",
"Bone and Bones / abnormalities",
"Bone and Bones / pathology",
"Dentin Dysplasia / pathology",
"Female",
"Humans",
"Magnetic Resonance Imaging",
"Melorheostosis / drug therapy",
"Multimodal Imaging",
"Rare Diseases / drug therapy",
"Tomography, X-Ray Computed",
"Anti-Inflammatory Agents, Non-Steroidal",
"Dentin dysplasia sclerotic bones"
],
"pmcid": "PMC4258217",
"pmid": "25489356",
"title": "Melorheostosis: a rare entity: a case report",
"year": "2014"
}
|
PMC4258217
|
Melorheostosis is a rare entity belonging to the group of sclerotic bone dysplasias. Described for the first time in 1922 by Leri, it remains imperfectly known as clinical presentations are highly variable, and the etiological diagnosis is not fully elucidated. We report a case of polyostoticmelorheostosis for which radiological investigations were complete, in order to study this disease.
|
{
"authors": [
"Paul Gisasola",
"Ainara Iriarte",
"Martha Rosa Larez",
"Laura Casanova",
"Luis Bujanda"
],
"case_amount": 1,
"doi": "10.1186/s13223-018-0313-2",
"journal": "Allergy Asthma Clin Immunol",
"journal_detail": "2019 Feb 28;15:12.",
"keywords": [
"eosinophilic",
"eosinophilic esophagitis",
"esophagitis",
"mediastinal abscess"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/30858868/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC6396444",
"pmid": "30858868",
"title": "Mediastinal abscess, an unusual way of presentation of eosinophilic esophagitis",
"year": "2019"
}
|
PMC6396444
|
Eosinophilic esophagitis (EoE) is one of the most prevalent esophageal diseases and the leading cause of dysphagia and food impaction in children and young adults. EoE represents a chronic, local immune-mediated esophageal disease, characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation. Mediastinal abscess is an uncommon condition that typically appears after esophageal perforations or thoracic surgeries, usually requiring treatment for surgical intervention due to its high morbidity-mortality. Mediastinal abscess, outside these two contexts, is extremely rare. We present the case of a mediastinal abscess secondary to EoE. It is important to think about this entity when there is a mediastinal abscess without trauma or previous surgery.
|
{
"authors": [
"Gaurav Saini",
"R K Sen",
"Anoop Kalia",
"Sagar Kadam"
],
"case_amount": 1,
"doi": "10.13107/jocr.2250-0685.1432",
"journal": "J Orthop Case Rep",
"journal_detail": "2019;9(3):79-83.",
"keywords": [
"floating knee",
"hoffa",
"polytrauma"
],
"license": "CC BY-NC-SA",
"link": "https://pubmed.ncbi.nlm.nih.gov/31559235/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC6742877",
"pmid": "31559235",
"title": "Implant-associated Hoffa's Fracture in a Floating Knee: A Case Report and Review of Literature",
"year": "2019"
}
|
PMC6742877
|
Introduction:
Complex floating knee in the presence of a previous implant creates an unusual fracture pattern which is a rare entity and poses a unique challenge in management and subsequent rehabilitation.
Case report:
A 56-year-old psychiatric patient who jumped from height had a polytrauma and a floating knee injury. Following the primary care and damage control surgery with knee-spanning fixator at some other centers, he was shifted to us on ventilator care and was directly admitted to intensive care unit for further management. On presentation, it was a floating knee injury with gross comminution of both femur and tibia with associated Hoffa with bent implant in situ. It was managed by plating of both lower end femur and tibia and at the end of 6 months, showed a satisfactory outcome.
Conclusion:
Floating knee injuries further complicated by the presence of the previous implant in a polytrauma situation poses a unique challenge which requires meticulous surgical planning and prolonged rehabilitation to achieve satisfactory outcome.
|
{
"authors": [
"Anna Levy",
"Etienne Very",
"François Montastruc",
"Philippe Birmes",
"Adeline Jullien",
"Louis Richaud"
],
"case_amount": 7,
"doi": "10.3389/fpsyt.2022.875636",
"journal": "Front Psychiatry",
"journal_detail": "2022 May 2;13:875636.",
"keywords": [
"encephalopathy",
"hyperammonemia",
"interaction",
"lithium",
"pharmacokinetic interaction",
"valproate sodium"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/35586415/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC9108155",
"pmid": "35586415",
"title": "Case Report: A Case of Valproic Acid-Induced Hyperammonemic Encephalopathy Associated With the Initiation of Lithium: A Re-duplicable Finding",
"year": "2022"
}
|
PMC9108155
|
Introduction:
Hyperammonemic encephalopathy (HAE) is a serious adverse effect of valproate semisodium, which is facilitated by the potential for drug interaction. However, despite frequent co-prescription of valproate semisodium and lithium, the role of this combination in the occurrence of HAE has not been defined in the literature. This case report concerns the occurrence of HAE concomitant with the initiation of lithium in a 29-year-old patient who had been placed on valproate semisodium for a schizoaffective disorder.
Case report:
Due to a relapse while on a combined antipsychotic and mood-stabilizing therapy (paliperidone palmitate and valproate semisodium), a cross-taper from valproate semisodium to lithium was proposed. The initiation of lithium was accompanied by an acute confusional syndrome, an elevated serum valproate level and hyperammonemia suggestive of drug-induced HAE. The discontinuation of lithium and reduction of valproate semisodium led to neurological improvement, until a recrudescence of psychiatric symptoms justified a rechallenge of the combination within the framework of a new cross-taper. As soon as Lithium was re-initiated, an increase in the serum valproate level and hyperammonemia were again noted.
Discussion:
The mechanisms of valproate-related HAE involve various metabolic pathways. In this case, exploration of the iatrogenic hypothesis focused on the imputability of concomitant cannabis use and co-prescriptions of benzodiazepines, antipsychotics, and in all likelihood, mood stabilizers.
Conclusion:
Therefore, this case study suggests that Lithium plays a role in serum valproate level elevation, and supports the hypothesis of an association between an elevated serum valproate level, hyperammonemia and reversible encephalopathy. A more in-depth pharmacokinetic exploration would provide a better understanding of the mechanisms of these interactions and support for the benefit-risk balance associated with this frequent co-prescription.
|
{
"authors": [
"Fang-E Shi",
"Mei-Fang Chen",
"Yong-Jie Li",
"Gui-Ying Dong",
"Ji-Hong Zhu"
],
"case_amount": 1,
"doi": "10.3389/fmed.2022.895923",
"journal": "Front Med (Lausanne)",
"journal_detail": "2022 Jul 7;9:895923.",
"keywords": [
"campylobacter jejuni",
"guillain-barre syndrome",
"facial paralysis",
"hemophagocytic lymphohistiocytosis",
"ophthalmoplegia",
"peripheral nerve injury"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/35872780/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC9302883",
"pmid": "35872780",
"title": "Campylobacter jejuni-Associated Hemophagocytic Lymphohistiocytosis and Guillain-Barre Syndrome: A Case Report",
"year": "2022"
}
|
PMC9302883
|
Campylobacter jejuni (C. jejuni), a Gram-negative bacterium, belongs to microaerobic bacteria. We reported a 21-year-old male patient diagnosed with hemophagocytic lymphohistiocytosis (HLH) due to C. jejuni infection, who presented with multiple clinical manifestations of peripheral nerve injury, such as ophthalmoplegia, facial paralysis, and urinary retention during the treatment. Electromyography showed neurogenic injury and the final diagnosis was Guillain-Barre Syndrome (GBS). After treatment of dexamethasone combined with immunoglobulin, the patient was discharged from the hospital with partial recovery of neurological symptoms.
|
{
"authors": [
"Saad Habib",
"Nicholas Fuca",
"Mohammed Azam",
"Abdul Hasan Siddiqui",
"Kartikeya Rajdev",
"Michel Chalhoub"
],
"case_amount": 1,
"doi": "10.1016/j.rmcr.2018.10.010",
"journal": "Respir Med Case Rep",
"journal_detail": "2018 Oct 16;25:311-313.",
"keywords": null,
"license": "CC BY-NC-ND",
"link": "https://pubmed.ncbi.nlm.nih.gov/30386722/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC6205350",
"pmid": "30386722",
"title": "Achromobacter xylosoxidans/denitrificans bacteremia and subsequent fatal Escherichia coli/ Streptococcus anginosus pleural empyema",
"year": "2018"
}
|
PMC6205350
|
Achromobacter xylosoxidans, a gram-negative bacillus with low virulence has rarely been reported to cause clinically significant infections. We report an unusual case of MDR Achromobacter xylosoxidans/denitrificans bacteremia from a peripherally inserted central catheter (PICC) and subsequent fatal pleural empyema due to MDR Escherichia coli and Streptococcus anginosus. A 44-year-old male presented to the hospital with chief complaints of chest tightness associated with a productive cough. He was found to have pleural empyema secondary to MDR E. coli and S. anginous. Three months prior to current presentation, he had a history of MDR A. xylosoxidans originating from a PICC. The patient expired even after appropriate management. Thoracic empyema continues to cause significant morbidity and mortality despite the improvement of antimicrobial therapy and the existence of multiple options for drainage of the infected pleural space. The bacteriology of thoracic empyema has been changing since the introduction of antibiotics. Typical antibiotics used to treat these MDR pathogens have become obsolete. Therefore, physicians should be aggressive in their diagnostic approach to pleural empyema, since the isolation of MDR aerobic gram-negative bacilli or multiple pathogens from the pleural fluid is associated with a poor prognosis and indicates a need for more aggressive antimicrobial chemotherapy. Also, the association of indwelling medical devices and MDR Achromobacter bacteremia should be known.
|
{
"authors": [
"Calvin Ka-Fung Lo",
"Conor Broderick",
"Aleksandra Stefanovic",
"William Connors",
"Melanie Murray"
],
"case_amount": 1,
"doi": "10.1099/acmi.0.000560.v3",
"journal": "Access Microbiol",
"journal_detail": "2023 Jun 28;5(6):acmi000560.v3.",
"keywords": [
"16s rrna",
"actinomycetes",
"gordonia",
"central line-associated bloodstream infection"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/37424562/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10323808",
"pmid": "37424562",
"title": "Gordonia sputi-associated bloodstream infection in a renal transplant patient with chronic indwelling central venous catheter: a case report and literature review",
"year": "2023"
}
|
PMC10323808
|
Introduction:
Although rare, human infections caused by Gordonia spp. have been reported, especially within the immunocompromised population and those with long-term indwelling devices. We report a case of Gordonia spp. bacteraemia in a renal transplant patient and present a literature review on microbiological identification methods of this organism.
Case presentation:
A 62-year-old female renal transplant recipient admitted to hospital with a 2-month history of dry cough and fevers occurring weekly when receiving electrolyte replacement infusions via a Groshong line. Over 2 weeks, blood cultures repeatedly isolated a Gram-positive bacillus solely in aerobic bottles, and this was initially reported as Rhodococcus spp. by the local microbiology laboratory. Chest computed tomography (CT) showed multiple ground-glass lung opacities suggestive of septic pulmonary emboli. As central line-associated bloodstream infection was suspected, empirical antibiotics were initiated and the Groshong line was removed. The Gram-positive bacillus was later confirmed by the reference laboratory as Gordonia sputi via 16S rRNA sequencing. Vancomycin and ciprofloxacin for a duration of 6 weeks were completed as targeted antimicrobial therapy. After treatment, the patient remained symptom-free with marked improvement on repeat CT chest imaging.
Conclusion:
This case illustrates the challenges surrounding identification of Gordonia spp. and other aerobic actinomycetes. 16S rRNA gene sequencing may be a preferred identification method, especially when initial workup of a weakly acid-fast organism fails to make an identification or shows discrepant results using traditional diagnostic modalities.
|
{
"authors": [
"Ronghua Wu",
"Xing Liu",
"Yajun Song",
"Shanhong Yi",
"Wei Chen",
"Wanlei Fu",
"Jingzhen Zhu"
],
"case_amount": 1,
"doi": "10.3389/fped.2022.904275",
"journal": "Front Pediatr",
"journal_detail": "2022 Jun 28;10:904275.",
"keywords": [
"case report",
"rhabdomyosarcoma",
"spontaneous rupture",
"testis",
"unilateral ptosis"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/35837241/",
"major_mesh_terms": [],
"mesh_terms": [],
"pmcid": "PMC9273775",
"pmid": "35837241",
"title": "Spontaneous Rupture of Rhabdomyosarcoma of the Testis With Unilateral Ptosis: A Case Report and Literature Review",
"year": "2022"
}
|
PMC9273775
|
Spontaneous rupture of testicular rhabdomyosarcoma is very rare. We report a case of spontaneous testicular rupture that was pathologically confirmed as rhabdomyosarcoma with unilateral blepharoptosis. The patient, a 19-year-old male, and his father had weakness of the left eyelid muscle. The patient was suspected to have a right inguinal hernia by a family doctor but was not treated further. 2 days later, there was skin itching in the right inguinal area, accompanied by redness, swelling and discomfort of the right scrotum, and the patient went to the local hospital again. Ultrasound examination showed that a contusion of the right testis may have been complicated with orchitis. Oral levofloxacin was ineffective. In addition, the swelling of scrotal increased significantly. He came to the emergency room of our hospital and also was treated with levofloxacin, but the pain was still not relieved. CT and ultrasound examination could not identify the cause of the disease. Exploration of the right scrotum was performed under general anesthesia and confirmed that the right testis had spontaneously ruptured. The pathological diagnosis was rhabdomyosarcoma of the right testis. Testicular rhabdomyosarcoma is clinically rare, and spontaneous rupture is even rarer. The pathogenesis of the disease needs to be further studied, and the diagnosis should be made on a case-by-case basis. Overall, the prognosis of testicular rhabdomyosarcoma is poor. As seen in this case, further study is required to determine whether there is some association between testicular rhabdomyosarcoma and ptosis. Unfortunately, the patient's family rejected a genetic examination because of financial difficulty. We only report a single case of this rare phenomenon here.
|
{
"authors": [
"Ashok Y Kshirsagar",
"Nitin R Nangare",
"Mayank A Vekariya",
"Vaibhav Gupta",
"Akshay S Pednekar",
"J V Wader",
"Abhishek Mahna"
],
"case_amount": 1,
"doi": "10.1016/j.ijscr.2014.04.009",
"journal": "Int J Surg Case Rep",
"journal_detail": "2014;5(7):393-5.",
"keywords": [
"adenosquamous carcinoma",
"ampulla of vater (amv)",
"pancreaticoduodenectomy (pd)"
],
"license": "CC BY-NC-ND",
"link": "https://pubmed.ncbi.nlm.nih.gov/24879329/",
"major_mesh_terms": [],
"mesh_terms": [],
"pmcid": "PMC4064426",
"pmid": "24879329",
"title": "Primary adenosquamous carcinoma of ampulla of Vater-A rare case report",
"year": "2014"
}
|
PMC4064426
|
Introduction:
Primary adenosquamous carcinoma (ASC) of the ampulla of Vater (AmV) is extremely rare. Carcinoma of the ampulla of Vater tends to manifest early due to biliary outflow obstruction, as opposed to pancreatic neoplasms that often are advanced at the time of diagnosis. Periampullary carcinomas are treated by pancreaticoduodenectomy (PD). Adenosquamous carcinoma carries very dismal prognosis.
Presentation of case:
Here we present a case of 58-year-old male who was presented with abdominal pain, jaundice and anorexia with no history of (h/o) pruritus and clay colored stool. All blood investigations were normal except liver function tests (LFTs). Ultrasonography (USG) of abdomen suggestive of periampullary mass with dilated pancreatico-biliary tree. Endoscopic retrograde cholangiopancreatography (E.R.C.P.) demonstrated large deformed and bulky papilla with ulcerated lesion with infiltration in to duodenum. Exploratory laprotomy proceeds Whipple's pancreaticoduodenectomy done. Histopathology revealed adenocarcinoma of the ampulla of Vater. Immunohistochemistry was confirmatory of adenosquamous carcinoma.
Discussion:
Adenosquamous carcinoma (ASC) is defined as a tumor in which both glandular and squamous elements are histologically malignant. Compared to adenocarcinoma, ASC of the AmV is a rare malignancy. Preoperative diagnosis is difficult because of the lack of defining characteristics in imaging studies and the difficulty in acquiring both malignant components by limited biopsy. Periampullary carcinomas are treated by pancreaticoduodenectomy.
Conclusion:
Adenosquamous carcinoma is a very rare form of cancer of the AmV. Pancreaticoduodenectomy is the treatment of choice though early recurrence and distal metastasis may be encountered after surgery. Follow-up should be more frequent to detect possible early recurrence and distal metastasis.
|
{
"authors": [
"Hasham Saeed",
"Leonardo Marmolejos",
"Roma Patel",
"Tanya Shankar",
"Asnia Latif",
"Muniba Naqi",
"William Farrer",
"Carlos Remolina"
],
"case_amount": 1,
"doi": "10.1016/j.rmcr.2023.101884",
"journal": "Respir Med Case Rep",
"journal_detail": "2023 Jun 4;45:101884.",
"keywords": [
"ntpe",
"nonthrombotic pulmonary emboli",
"pwid",
"patients with injection drug use",
"septic emboli"
],
"license": "CC BY-NC-ND",
"link": "https://pubmed.ncbi.nlm.nih.gov/37577124/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10415754",
"pmid": "37577124",
"title": "Pleurisy secondary to nonthrombotic pulmonary emboli in a patient with intravenous drug use",
"year": "2023"
}
|
PMC10415754
|
Patients with injection drug use can have nonthrombotic pulmonary emboli (NTPE) of foreign insoluble particles that are either parts of the equipment used or mixed with the drug as an additive. These foreign particles can become a nidus for infection and inflammation. We present a case of a 31-year-old man with active intravenous drug use who initially presented with signs and symptoms of pleurisy and was found to have NTPE of septic refractile crystalline material as seen on bronchial wash and brush biopsy. We believe our patient likely had embolism of either crack particles, needle fragments or cotton-wool fragments that led to a localized inflammatory reaction and infection. This highlights the importance of obtaining detailed history and diagnostic workup. Once the diagnoses of bacterial endocarditis and thrombophlebitis are ruled out with blood cultures, transthoracic echocardiogram, trans-esophageal echocardiogram and/or CT scan (depending on the suspicion), NTPE should be considered and bronchoscopy with bronchoalveolar lavage with biopsy should be performed.
|
{
"authors": [
"K Törenek",
"H M Akgül",
"I S Bayrakdar"
],
"case_amount": 1,
"doi": "10.1155/2016/6426523",
"journal": "Case Rep Dent",
"journal_detail": "2016;2016:6426523.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/27547475/",
"major_mesh_terms": [],
"mesh_terms": [],
"pmcid": "PMC4980514",
"pmid": "27547475",
"title": "Ectopic Premolar Tooth in the Sigmoid Notch",
"year": "2016"
}
|
PMC4980514
|
Impaction of a mandibular premolar is relatively uncommon. Ectopic placement is more unusual and there has been no discussion in the literature of an ectopic mandibular premolar in the coronoid process. In this case report, we present an impacted ectopic mandibular permanent premolar in the sigmoid notch (incisura mandibulae) region. Etiology of the tooth and treatment options are discussed and illustrated by Cone Beam Computed Tomography (CBCT) images.
|
{
"authors": [
"Dhara Chaudhari",
"Sarah Khan",
"Atif Saleem",
"Tamarro Taylor",
"Chakradhar Reddy",
"Thomas Borthwick",
"Mark Young"
],
"case_amount": 2,
"doi": "10.1155/2013/259642",
"journal": "Case Rep Med",
"journal_detail": "2013;2013:259642.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/23818904/",
"major_mesh_terms": [],
"mesh_terms": [],
"pmcid": "PMC3683444",
"pmid": "23818904",
"title": "Obstructive jaundice as an initial manifestation of non-hodgkin lymphoma: treatment dilemma and high mortality",
"year": "2013"
}
|
PMC3683444
|
Introduction. Non Hodgkin lymphoma (NHL) presenting with obstructive jaundice is a rare occurrence. Because of rarity of combination, it is seldom considered in differential diagnosis of patients presenting with obstructive jaundice. It is considered treatable due to the chemosensitive nature of the disease and the recent advances in chemotherapy. Case Series. We present a case series of 2 patients with NHL presenting with obstructive jaundice as an initial manifestation. Both patients presented with obstructive jaundice and were diagnosed by CT guided liver biopsy. One patient died of sepsis and multiorgan failure before initiating chemotherapy and the second patient did not choose to undergo chemotherapy. Conclusion. Biliary obstruction is a sign of poor prognosis. The diagnosis of NHL needs to be considered in patients presenting with biliary obstruction. It can be associated with high mortality and poses treatment dilemma.
|
{
"authors": [
"Charlotte Spicher",
"Ruth Schneider",
"Peter Mönnings",
"Christiane Schneider-Gold",
"Dennis Kallenberg",
"Bilal Cevik",
"Carsten Lukas",
"Ralf Gold",
"Christos Krogias"
],
"case_amount": 1,
"doi": "10.1177/1756286418759188",
"journal": "Ther Adv Neurol Disord",
"journal_detail": "2018 Mar 1;11:1756286418759188.",
"keywords": null,
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/29552091/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC5846908",
"pmid": "29552091",
"title": "Mechanical thrombectomy in a young stroke patient with Duchenne muscular dystrophy",
"year": "2018"
}
|
PMC5846908
|
Background:
Duchenne muscular dystrophy (DMD) is an X-linked recessive skeletal muscle myopathy which is caused by mutations in the dystrophin gene. Lack of dystrophin also results to cardiomyopathy, which raises significantly the stroke risk in DMD-patients. However, data about therapeutic opportunities in the acute setting are scarce in literature. So far, only two cases receiving IV thrombolysis are described, one of them with fatal outcome.
Method:
Case report of a case of successful mechanical thrombectomy (MTE) in an acute ischemic stroke (AIS) patient with DMD and associated dilatative cardiomyopathy.
Results:
A 20-year old DMD-patient was transferred at 08:56 h to our department due to wake up stroke with severe right-sided hemiparesis and aphasia (NIHSS=20). Last-seen-normal was at 03:00 h. Cerebral CT-scan revealed only slight early ischemic changes (ASPECT-Score=8). CT-angiography detected occlusion of left middle cerebral artery (LMCA). MTE started rapidly at 9:23 h and using direct thrombus aspiration (Penumbra System®) complete recanalization was achieved 20 min later (TICI-grade 3). Considering the specific risks of general anesthesia in DMD, the procedure was performed with propofol, remifentanil and rocuronium. The patient recovered quickly from the acute symptoms, due to preexisting hypotonic tetraparesis his NIHSS-score at discharge was 12 points.
Conclusions:
To the best of our knowledge, this is the first report on MTE in a patient with DMD related cardioembolic stroke. In contrast to the few reports with IV thrombolysis, MTE seems to represent an optimal treatment option. Specific characteristics of DMD-patients like anesthetic regimen should be taken into account.
|
{
"authors": [
"Zhujun Chen",
"Kang Wang",
"Lintao Zhao",
"Liang Gong"
],
"case_amount": 1,
"doi": "10.3389/fonc.2023.1190100",
"journal": "Front Oncol",
"journal_detail": "2023 May 16;13:1190100.",
"keywords": [
"brca2 mutation",
"olaparib",
"pd-1 inhibitor",
"case report",
"lung squamous cell carcinoma"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/37260982/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10228719",
"pmid": "37260982",
"title": "BRCA2 mutation in advanced lung squamous cell carcinoma treated with Olaparib and a PD-1 inhibitor: a case report",
"year": "2023"
}
|
PMC10228719
|
Background:
Mutations in the human breast cancer susceptibility gene 2 (breast cancer 2, BRCA2) increase the risk of breast, ovarian and other cancers. Olaparib, an oral poly[adenosine diphosphate (ADP)-ribose] polymerase (PARP) inhibitor, is usually prescribed to treat BRCA mutated tumors, especially breast and ovarian cancers. Programmed cell death-1 (PD-1) inhibitors have revolutionized the treatment of lung cancer and many other cancers by destroying the interaction between receptors with ligands in the tumor-immune microenvironment and enabling T cells to recognize and attack cancer cells.
Case description:
In our study, we report a patient with advanced BRCA2 lung squamous cell carcinoma who received platinum-based chemotherapy combined with paclitaxel. Seven months later, the disease progressed. BRCA2 mutations were detected in peripheral blood by next-generation sequencing. After 2 months of treatment with Olaparib combined with Cindilimab, the patient was in partial remission and the progression-free survival (PFS) lasted for 6 months, but the patient developed immune renal damage.
Conclusions:
This study adds to the clinical data for the treatment of BRCA2 mutant non-small cell lung cancer by demonstrating that lung squamous cell carcinoma has a good response to PARP inhibitors. It also serves as a reminder that there may still be some negative effects from targeted superimposed immunotherapy.
|
{
"authors": [
"Qingshun Zhu",
"Lei Li",
"Xuguang Jiao",
"Jinqiu Xiong",
"Shengyong Zhai",
"Guangxu Zhu",
"PeiPei Cheng",
"Jianjun Qu"
],
"case_amount": 1,
"doi": "10.3389/fonc.2022.995738",
"journal": "Front Oncol",
"journal_detail": "2022 Oct 25;12:995738.",
"keywords": [
"axillary lymph node metastasis",
"gastric cancer",
"immunohistochemical staining",
"radical total gastrectomy",
"tumor markers"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/36387206/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC9641636",
"pmid": "36387206",
"title": "Rare metastasis of gastric cancer to the axillary lymph node: A case report",
"year": "2022"
}
|
PMC9641636
|
Lymph node metastasis of gastric cancer is more common, metastatic lymph nodes are often around the stomach, and metastasis is carried out in a certain order, but gastric cancer metastasis to axillary lymph nodes is very rare. Due to the small number of patients with this kind of metastasis, its clinical features and treatment are not very clear. We initially thought that the enlarged axillary lymph nodes were inflammatory lesions. Axillary lymph node biopsy was later diagnosed as gastric cancer metastases to axillary lymph nodes. The patient refused further treatment and died 11 months after the second operation because of multiple systemic metastases. We believe that metastasis of gastric cancer to axillary lymph nodes is rare and the prognosis is poor. In clinical work, the possibility of metastatic lymph nodes should be considered in patients with a history of gastric cancer with enlarged axillary lymph nodes.
|
{
"authors": [
"Larry Nichols",
"Kelsey Bree Harper",
"Keisha R Callins"
],
"case_amount": 1,
"doi": "10.1016/j.acpath.2022.100055",
"journal": "Acad Pathol",
"journal_detail": "2022 Sep 23;9(1):100055.",
"keywords": [
"female reproductive system",
"hellp syndrome",
"organ system pathology",
"pathology competencies",
"preeclampsia",
"pregnancy"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/36177063/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC9512840",
"pmid": "36177063",
"title": "Educational Case: Hemolysis elevated liver enzymes and low platelets (HELLP syndrome)",
"year": "2022"
}
|
PMC9512840
|
Recommended management of patients with preeclampsia starts with a comprehensive clinical maternal and fetal evaluation, including maternal complete blood count, platelets, creatinine, LDH, liver enzymes, and urine test for proteinuria, along with fetal ultrasonographic evaluation and fetal antepartum testing.7 Subsequent management depends on the results of this evaluation and on gestational age. Continued observation is recommended for a woman with a preterm fetus if she has gestational hypertension or preeclampsia without severe features, until delivery at 37 weeks of gestation in the absence of abnormal antepartum testing, preterm labor, premature rupture of membranes, or vaginal bleeding.7 There are numerous conditions precluding such expectant management including severe hypertension refractory to treatment, persistent headaches refractory to treatment, epigastric or right upper pain refractory to treatment, visual disturbances, motor deficit, altered sensorium, stroke, myocardial infarction, new or worsening renal dysfunction, pulmonary edema, suspected acute placental abruption, vaginal bleeding in the absence of placenta previa, eclampsia, or HELLP syndrome.7.
|
{
"authors": [
"Ogochukwu Jidechukwu Sokunbi",
"Bassey Olumide Udom",
"Naveen Kuzhippil Sreedhar",
"Michael Olutoyin Sanusi",
"Rajasekaran Premsekar"
],
"case_amount": 1,
"doi": "10.11604/pamj.2023.44.88.36076",
"journal": "Pan Afr Med J",
"journal_detail": "2023 Feb 15;44:88.",
"keywords": [
"nigeria",
"transcatheter closure",
"case report",
"interventional paediatric cardiology",
"ventricular septal defect"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/37193109/",
"major_mesh_terms": [
"Cardiac Catheterization / methods",
"Heart Septal Defects, Ventricular / surgery"
],
"mesh_terms": [
"Cardiac Catheterization / methods",
"Heart Septal Defects, Ventricular / surgery",
"Case Reports",
"Child, Preschool",
"Female",
"Hospitalization",
"Humans",
"Infant",
"Nigeria",
"Treatment Outcome",
"Weight Gain"
],
"pmcid": "PMC10182372",
"pmid": "37193109",
"title": "The first case of transcatheter device closure of perimembranous ventricular septal defect in Nigeria: a case report",
"year": "2023"
}
|
PMC10182372
|
Ventricular septal defect (VSD) is the most common congenital cardiac anomaly with a prevalence of 1.17 per 1000 live births. Haemodynamically significant VSDs require closure either surgical or transcatheter. We report a case of transcatheter device closure of a moderate-sized perimembranous ventricular septal defect (PmVSD), the first of its kind in Nigeria. The procedure was performed on a 23-month-old female weighing 10 kg who had presented with a history of frequent pneumonia and poor weight gain and signs of heart failure. The procedure was uncomplicated, and she was discharged 24 hours after the intervention. She had been followed-up two years post-procedure without complications and she had achieved appreciable weight gain. This non-surgical option was effective in this patient and provided the advantage of limited hospitalization, accelerated recovery, and intervention without the need for blood products. Such interventions should be scaled up in Nigeria and other sub-Saharan African countries.
|
{
"authors": [
"B Nandakishore",
"M Ramesh Bhat",
"Sonal Fernandes",
"Nisha J Marla"
],
"case_amount": 1,
"doi": "10.4103/ijstd.ijstd_3_21",
"journal": "Indian J Sex Transm Dis AIDS",
"journal_detail": "2022 Jan-Jun;43(1):68-69.",
"keywords": [
"balanitis",
"micaceous",
"pseudoepitheliomatous"
],
"license": "CC BY-NC-SA",
"link": "https://pubmed.ncbi.nlm.nih.gov/35846545/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC9282702",
"pmid": "35846545",
"title": "A rare presentation of pseudoepitheliomatous keratotic and micaceous balanitis with malignant transformation",
"year": "2022"
}
|
PMC9282702
|
Pseudoepitheliomatous keratotic and micaceous balanitis (PKMB) is a rare nonvenereal penile condition with a risk of malignant transformation. We report a case of PKMB in a 45-year-old male who presented with multiple keratotic growths over his glans penis after circumcision for long-standing phimosis. Histopathology revealed pseudoepitheliomatous hyperplasia and atypical cells. He was successfully treated with wide local excision.
|
{
"authors": [
"Mohd Yasir Beg",
"Lovenish Bains",
"Ratnesh Mahajan",
"Pawan Lal",
"Sharmana Choudhury",
"N Pritesh Kumar",
"Eva Wilse C Momin",
"Veer Pal"
],
"case_amount": 1,
"doi": "10.1155/2020/8845263",
"journal": "Case Rep Infect Dis",
"journal_detail": "2020 Aug 11;2020:8845263.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/32850159/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC7439188",
"pmid": "32850159",
"title": "Fulminant Necrotising Amoebic Colitis of Whole of Large Bowel: A Rare Complication of a Common Infectious Disease",
"year": "2020"
}
|
PMC7439188
|
Background:
Fulminant necrotising amoebic colitis (FulNAC) is an uncommon and grave complication of a very common infectious disease widely prevalent in tropical countries. In most of the cases reported, only a segment of large bowel was gangrenous. The involvement of the whole of the large bowel, as in our case, is very rare and has very high mortality ranging from 55% to 100%. Case Summary. A 50-year-old gentleman presented with an acute abdomen with a history of crampy abdominal pain and passage of blood mixed with mucous and loose stools. After resuscitation and investigations, the patient was taken up for laparotomy and the findings showed that the caecum was sloughed off and the entire large bowel had multiple perforations. Subtotal colectomy with ileostomy was performed. Histopathological examination showed evidence of pancolitis with multiple colonies of amoebic trophozoites. Discussion. Entamoeba histolytica is a protozoon that affects the large intestine and liver in humans. There can be various presentations of amoebiasis: asymptomatic infection (90%), symptomatic noninvasive infection (6-8%), acute amoebic colitis (dysentery), or fulminant colitis with perforation. FulNAC is an uncommon complication, difficult to diagnose and treat, and associated with a high mortality rate, ranging from 55% to 100%.
Conclusion:
It is important to consider the possibility of fulminant necrotising amoebic colitis (FulNAC) as an uncommon and fatal complication of amoebiasis, especially in tropical countries, where amoebiasis is prevalent. Early diagnosis and antiamoebic treatment, along with urgent aggressive surgical resection of the involved segment and exteriorization of the proximal and distal bowel ends, are shown to reduce mortality.
|
{
"authors": [
"Gianfranco Filippone",
"Giovanni Caruana",
"Claudia Calia",
"Violetta Moscaritolo",
"Vincenzo Argano"
],
"case_amount": 2,
"doi": "10.1016/j.ijscr.2017.12.018",
"journal": "Int J Surg Case Rep",
"journal_detail": "2018;42:179-181.",
"keywords": [
"aortic dissection",
"case series",
"intimal lesion",
"intramural hematoma"
],
"license": "CC BY-NC-ND",
"link": "https://pubmed.ncbi.nlm.nih.gov/29274600/",
"major_mesh_terms": [],
"mesh_terms": [],
"pmcid": "PMC5773468",
"pmid": "29274600",
"title": "Evidence of intimal tear in type A intramural hematoma of the aorta: A case series",
"year": "2018"
}
|
PMC5773468
|
Introduction:
Aortic intramural hematoma (IMH) is described as "dissection without intimal tear" due to rupture of vasa vasorum, which results in bleeding within the tunica media in the absence of intimal disruption or blood flow communication. The aim of our study is to validate perioperative evidence of intimal entry tear in patients with IMH and to suggest that this entity may represent a part of a disease and not a separate disease.
Presentation of cases:
We report two patients admitted to our institution with sudden onset thoracic pain. A CT scan showed an aneurysm of the ascending aorta complicated by type A IMH. The patients underwent open operation. Surgical set-up has included right axillary artery as arterial inflow, no cross-clamp before hypothermic circulatory arrest and Kazui protocol for selective antegrade cerebral perfusion. We found no evidence of intimal flap, but we identified an intimal tear in both patients. A hemiarch procedure associated with root replacement, using two-grafts techniques was performed in both cases. The postoperative course was uneventful and the patients were discharged home.
Discussion:
Recent data are emerging from the radiologic literature about the evidence of intimal lesions in IMH, but surgical reports are scant. The evidence of intimal tears contributes to consider as questionable the etiological role of vasa vasorum and it may justify updates in the management.
Conclusion:
We consider that IMH may represent a part of a disease (aortic dissection), depicted by radiological images in a specific single instant of its clinical evolution.
|
{
"authors": [
"Ying Si",
"Bo Sun",
"Ting Zhao",
"Ke Xiao",
"Dong-Xia Zhao",
"Yong-Mao Huang"
],
"case_amount": 1,
"doi": "10.3389/fonc.2022.873338",
"journal": "Front Oncol",
"journal_detail": "2022 Jul 13;12:873338.",
"keywords": [
"acute abdomen",
"focal nodular hyperplasia (fnh)",
"liver",
"rupture",
"surgery"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/35912213/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC9328801",
"pmid": "35912213",
"title": "Case Report: Rare Acute Abdomen: Focal Nodular Hyperplasia With Spontaneous Rupture",
"year": "2022"
}
|
PMC9328801
|
Focal nodular hyperplasia (FNH) of the liver is a benign lesion characterized by hypertrophic nodules with central star-shaped fibrous scars. The etiology and pathogenesis of FNH are not completely understood. A 43-year-old man was hospitalized because of acute abdominal pain. Emergency computed tomography(CT) showed hepatic tumor rupture and bleeding. The patient's condition improved following arteriographic embolization to stop bleeding. Laparotomy confirmed spontaneous rupture and hemorrhage of focal hyperplasia and the patient remains asymptomatic after an uneventful recovery. FNH with spontaneous rupture and bleeding is extremely rare. Currently, there is no unified management standard for FNH and most previous studies recommend observation and follow-up. We recommend consideration of surgical treatment of cases with spontaneous rupture and bleeding.
|
{
"authors": [
"Esra Hayriye Ataoglu",
"Betul Demir",
"Mazhar Tuna",
"Bilger Cavus",
"Faik Cetin",
"Levent Umit Temiz",
"Savas Ozturk",
"Mustafa Yenigun"
],
"case_amount": 1,
"doi": "10.12659/AJCR.883326",
"journal": "Am J Case Rep",
"journal_detail": "2012;13:187-90.",
"keywords": [
"sjögren syndrome",
"distal renal tubular acidosis",
"hypopotassemic paralysis"
],
"license": "NO-CC CODE",
"link": "https://pubmed.ncbi.nlm.nih.gov/23569525/",
"major_mesh_terms": [],
"mesh_terms": [],
"pmcid": "PMC3615933",
"pmid": "23569525",
"title": "Sjögren syndrome presenting with hypopotassemic periodic paralysis due to renal tubular acidosis",
"year": "2012"
}
|
PMC3615933
|
Background:
Sjögren syndrome (SS) is an autoimmune-lymphoproliferative disorder characterized by mononuclear cell infiltration of exocrine glands. Clinically, Sjögren syndrome (SS) has a wide spectrum, varying from autoimmune exocrinopathy to systemic involvement. There have been few cases reporting that primary SS developed with distal renal tubular acidosis clinically.
Case report:
Here, we present a case with primary Sjögren syndrome accompanied by hypopotassemic paralysis due to renal tubular acidosis. Severe hypopotassemia, hyperchloremic metabolic acidosis, alkaline urine and disorder in urinary acidification test were observed in the biochemical examination of the 16-year-old female patient, who had applied to our clinic for extreme loss of muscle force. After the examinations it was determined that the patient had developed Type 1 RTA (distal RTA) due to primary Sjögren syndrome. Potassium and alkaline replacement was made and an immediate total recovery was achieved.
Conclusions:
Hypopotassemic paralysis due to primary Sjögren syndrome is a rare but severe disorder that could lead to death if not detected early and cured appropriately. Thus, effective treatment should be immediately initiated in cases where severe hypopotassemia is accompanied by metabolic acidosis, and the cases should also be examined for extraglandular involvement of SS.
|
{
"authors": [
"Mayu Sugai",
"Okinori Murata",
"Hiroki Oikawa",
"Hiroshi Katagiri",
"Ami Matsumoto",
"Hiromi Nagashima",
"Tamotsu Sugai",
"Makoto Maemondo"
],
"case_amount": 3,
"doi": "10.1016/j.rmcr.2020.101202",
"journal": "Respir Med Case Rep",
"journal_detail": "2020 Aug 28;31:101202.",
"keywords": [
"bone marrow involvement",
"pancytopenia",
"renal sarcoidosis",
"sarcoidosis"
],
"license": "CC BY-NC-ND",
"link": "https://pubmed.ncbi.nlm.nih.gov/32944498/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC7481816",
"pmid": "32944498",
"title": "A case of bone marrow involvement in sarcoidosis with crescentic glomerular lesions",
"year": "2020"
}
|
PMC7481816
|
Renal and bone marrow involvements in sarcoidosis are rare. We experienced the case of a 67-year-old man with systemic sarcoidosis, with bone marrow involvement, hepatic involvement and a unique constellation of renal lesion with cellular crescent formation. Immunosuppressive therapy was helpful for maintaining the stability of his pancytopenia, hepatic function and renal function. To the best of our knowledge, the association between sarcoidosis, bone marrow involvement and crescentic glomerulonephritis has been reported in only few cases in literature.
|
{
"authors": [
"Junpei Sasajima",
"Kotaro Okamoto",
"Masato Taniguchi"
],
"case_amount": 1,
"doi": "10.1159/000444249",
"journal": "Case Rep Gastroenterol",
"journal_detail": "2016 May 19;10(1):75-80.",
"keywords": [
"digestive system",
"endoscopy",
"neoplasm metastasis",
"pancreatic neoplasm",
"stomach"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/27403106/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC4929381",
"pmid": "27403106",
"title": "Hematogenous Gastric Metastasis of Pancreatic Cancer",
"year": "2016"
}
|
PMC4929381
|
While the gastric involvement of pancreatic cancer is occasionally observed as the result of direct invasion, hematogenous gastric metastasis is rare. A 72-year-old Japanese male presented with general fatigue, pollakiuria, and thirst. Computed tomography revealed a 4.6-cm solid mass in the pancreatic tail and a 4.2-cm multilocular cystic mass in the pancreatic head with multiple liver and lymphatic metastasis. Notably, two solid masses were detected in the gastric wall of the upper body and the antrum; both were separated from the primary pancreatic cancer and seemed to be located in the submucosal layer. Esophagogastroduodenoscopy revealed a submucosal tumor with a normal mucosa in the posterior wall of the upper body of the stomach, suggesting the gastric hematogenous metastasis of pancreatic cancer. The suspected diagnosis was unresectable pancreatic cancer with multiple metastases that was concomitant with the intraductal papillary mucinous neoplasm of the pancreas.
|
{
"authors": [
"Takashi Suehiro",
"Yuto Satake",
"Mamoru Hashimoto",
"Manabu Ikeda"
],
"case_amount": 1,
"doi": "10.3389/fpsyt.2021.665868",
"journal": "Front Psychiatry",
"journal_detail": "2021 Jun 10;12:665868.",
"keywords": [
"de clerambault's syndrome",
"delusion",
"dementia",
"dementia with lewy bodies",
"erotomania"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/34177653/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC8222603",
"pmid": "34177653",
"title": "Case Report: De Clerambault's Syndrome in Dementia With Lewy Bodies",
"year": "2021"
}
|
PMC8222603
|
Background: Erotomania, also known as de Clerambault's syndrome, is characterized by the delusion that a person has fallen in love with the patient. It occasionally appears secondary to psychiatric disorders and organic brain diseases. However, there have been no reports on cases secondary to dementia with Lewy bodies (DLB). Case Presentation: The patient was an 83-year-old woman who lived alone. Mild cognitive impairment appeared at the age of 82 years. Soon after, she had the delusional conviction that her family doctor was in love with her. Her symptoms, such as gradually progressive cognitive impairment, cognitive fluctuations, and parkinsonism, indicated DLB. She was treated with a small dose of antipsychotic agents. Conclusions: This case report suggests the possibility of de Clerambault's syndrome during the early stages of DLB. Further investigations are required to clarify the mechanism and treatment of de Clerambault's syndrome in patients with DLB.
|
{
"authors": [
"Chaoyong Shen",
"Jiaoxue He",
"Xiaoyan Le",
"Linmao Zheng",
"Dan Cao"
],
"case_amount": 1,
"doi": "10.2147/OTT.S237634",
"journal": "Onco Targets Ther",
"journal_detail": "2019 Dec 20;12:11339-11344.",
"keywords": [
"tae",
"chemotherapy",
"glucagonoma",
"necrolytic migratory erythema",
"somatostatin"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/31920326/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC6929939",
"pmid": "31920326",
"title": "Application of Somatostatin, Chemotherapy Combined with TAE in Heterogeneous Glucagonoma Presented with Necrolytic Migratory Erythema",
"year": "2019"
}
|
PMC6929939
|
Glucagonoma, a rare neuroendocrine tumor of the pancreas, which is often misdiagnosed because of non-characteristic clinical manifestations. In addition, the treatment has not been well established for this disease so far. We here report a case of glucagonoma previous misdiagnosed as recurrent erythema. In this case, necrolytic migratory erythema was the main clinical manifestation, and he received surgical resection after admission although with liver metastasis. Postoperative pathological results showed that the heterogeneity of proliferative index in primary (Ki-67: 5~10%) and metastatic (Ki-67: 25~30%) tumors were obviously observed. One month postoperatively, abdominal CT and MRI showed multiple liver metastasis (type III) again. Interestingly, the skin rash was obviously improved after treatment with somatostatin combined with chemotherapy (octreotide, temozolomide and capecitabine). Subsequently, the patient received transarterial embolization (TAE). Up to now, no progression was noted for liver metastasis. Due to its rarity, clinical diagnosis is challenging; thus, further understanding of the disease by clinicians is helpful for early diagnosis and treatment, so as to improve the prognosis of patients.
|
{
"authors": [
"Zhi-Wei Hu",
"Wang-Zhong Gao",
"Yong-Quan Gu",
"Bing Chen",
"Guang-Chang Zhu",
"Wei-Tao Liang",
"Ya-Chan Ning"
],
"case_amount": 1,
"doi": "10.1155/2012/608358",
"journal": "Case Rep Vasc Med",
"journal_detail": "2012;2012:608358.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/23326752/",
"major_mesh_terms": [],
"mesh_terms": [],
"pmcid": "PMC3540647",
"pmid": "23326752",
"title": "Aortic deceleration injury treated by endograft: a case report with 11-year followup",
"year": "2012"
}
|
PMC3540647
|
Aortic deceleration injury is a common and critical condition following automobile accident with high fatality. The survivors complicated with associated serious injuries are even rare and definitive treatment is required. A 37-year-old male patient had both aortic blunt injury and coronary artery injury after a frontal car collision. After failed coronary artery percutaneous transluminal angioplasty (PTA) and deteriorated aortic lesion, the ruptured aorta was subsequently successfully treated by us with a self-made individualized endograft. The endograft was well in position and the patient functioned well in 11-year followup. With the development of endograft and technique, the endovascular treatment may be an option for patients with complicated aortic blunt injury. Yet careful patient selection and the long-term followup are essential.
|
{
"authors": [
"Yubo Liao",
"Guo Zhou",
"Chong Yang",
"Yu Zhang"
],
"case_amount": 2,
"doi": "10.3389/fsurg.2022.944980",
"journal": "Front Surg",
"journal_detail": "2022 Sep 9;9:944980.",
"keywords": [
"diagnosis",
"hepatic echinococcosis",
"surgery",
"treatment",
"“egg-shelled” lesions"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/36157431/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC9500339",
"pmid": "36157431",
"title": "Uncommon abdominal \"egg-shelled\" lesions mimic hepatic echinococcosis: Two cases report",
"year": "2022"
}
|
PMC9500339
|
Background:
Primary abdominal "egg-shelled" lesions with positive anti-echinococcus IgG antibody were misdiagnosed as echinococcosis.
Case presentation:
Herein we report two cases with primary abdominal "egg-shelled" lesions were misdiagnosed as echinococcosis. Case 1: A 44-year-old woman presented to our department with a history of slight abdominal pain for 4 months. After admission, the laboratory tests indicated a positive anti-echinococcus IgG antibody status. The contrast-enhanced CT scan showed a 12 × 12 cm "me contrast-mass located in the hepatorenal area. The patient had the entire mass and the right adrenal gland resected. This patient recovered smoothly and was discharged uneventfully 20 days after the operation. The pathologic diagnoses was adrenal lymphangioma. Case 2: A 55-year-old woman was admitted with a history of an abdominal mass for over 10 years. After admission, her anti-echinococcus IgG antibody was positive. The contrast-enhanced CT scan revealed a heterogeneous, solid mass measuring 10 × 9 × 8 cm in the right hepatic lobe. A laparoscopic exploration was performed, and the surgery revealed that the mass arose from the retroperitoneal tissue rather than the liver. Finally, the pathologic diagnoses were paraganglioma with necrosis and cystic changes.
Conclusion:
Enhanced CT scan and contrast-enhanced ultrasound scans are important for distinguishing echinococcosis disease from the other "egg-shelled" lesions. Surgical resection is the main treatment method for this disease. Minimally invasive surgery is recommended but should be performed by experienced surgical teams. Immunohistochemical examination is important for the pathologic diagnosis.
|
{
"authors": [
"F Javier Barrientos-Lezcano",
"Guadalupe Corchero-Martín",
"Ana Belén González-Núñez",
"Francisco Soler-Presas"
],
"case_amount": 1,
"doi": "10.4103/ams.ams_365_20",
"journal": "Ann Maxillofac Surg",
"journal_detail": "2021 Jan-Jun;11(1):169-172.",
"keywords": [
"dental implant",
"floor of the mouth",
"haemorrhage"
],
"license": "CC BY-NC-SA",
"link": "https://pubmed.ncbi.nlm.nih.gov/34522677/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC8407642",
"pmid": "34522677",
"title": "Life-Threatening Sublingual Hematoma after Mandibular Implant Placement - A Case Report",
"year": "2021"
}
|
PMC8407642
|
Rationale:
Sublingual hematoma is a potentially lethal complication following mandibular implant placement. Due to the scarce cases reported, the management is controversial. In this article, a case is discussed focusing on the different treatment options to establish an orientative guideline.
Patient concerns:
A patient with sublingual hematoma following implant surgery was urgently referred. Despite no active bleeding, breathing difficulty due to oropharyngeal obstruction and oxygen saturation decrease were present.
Diagnosis:
Stable sublingual hematoma with respiratory distress, based on clinical findings and observation.
Treatment:
Under local anaesthesia, percutaneous tracheostomy without previous intubation was performed for airway preservation. No surgical approach for the hematoma was made.
Outcomes:
Uneventful recovery with spontaneous resolution of the hematoma in few days.
Takeaway lessons:
Anatomic knowledge of this area and proper surgical planning are required to avoid this complication. Regarding management, airway preservation is mandatory. Surgical approach for the bleeding source will depend on hematoma progression.
|
{
"authors": [
"Shota Horiike",
"Yasuhiro Nakajima",
"Mamoru Matsuo",
"Akinori Kageyama",
"Ayako Motomura",
"Takashi Tsujiuchi",
"Ryuta Saito"
],
"case_amount": 1,
"doi": "10.2176/jns-nmc.2022-0060",
"journal": "NMC Case Rep J",
"journal_detail": "2023 Jun 6;10:157-162.",
"keywords": [
"jefferson fracture",
"dysarthria",
"occipitocervical posterior fixation",
"rehabilitation for decannulation",
"traumatic basilar impression"
],
"license": "CC BY-NC-ND",
"link": "https://pubmed.ncbi.nlm.nih.gov/37398915/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10310350",
"pmid": "37398915",
"title": "Speech-language Pathology Rehabilitation in a Case of Jefferson Fracture Complicated with Lower Cranial Nerve Palsies",
"year": "2023"
}
|
PMC10310350
|
A 68-year-old man presented with a Jefferson fracture leading to lower cranial nerve palsies affecting the ninth, tenth, and twelfth cranial nerves with a traumatic basilar impression. On the X day, the patient underwent occipitocervical posterior fixation surgery; the surgery was uneventful. However, just after the surgery, epipharyngeal palsy and airway obstruction occurred. Consequently, tracheostomy was needed. On the X+8 day, speech-language pathology (SLP) therapy was initiated for decannulation. On the X+21 day, the patient could clear all the checkpoints and was decannulated. On the X+36 day, the patient was discharged home and SLP therapy was continued. On the X+171 day, his SLP therapy was halted. However, the patient continued to complain that he could not speak as fast as before, and his quality of life remained compromised. Some studies reported that lower cranial nerve palsies affecting the ninth to the twelfth cranial nerve occur in conjunction with Jefferson fractures. Thus, SLP therapy is crucial for Jefferson fracture cases.
|
{
"authors": [
"Arun Sasikumar",
"Ajith Joy",
"M R A Pillai",
"Boben Thomas"
],
"case_amount": 1,
"doi": "10.4103/0972-3919.198483",
"journal": "Indian J Nucl Med",
"journal_detail": "2017 Jan-Mar;32(1):54-56.",
"keywords": [
"18f-fluorodeoxyglucose positron emission tomography/computed tomography",
"lymphoma",
"pathological fracture",
"uterine cervix"
],
"license": "CC BY-NC-SA",
"link": "https://pubmed.ncbi.nlm.nih.gov/28242988/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC5317073",
"pmid": "28242988",
"title": "18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Scan in an Unusual Case of Lymphoma with Secondary Involvement of Uterine Cervix Presenting as a Pathological Fracture",
"year": "2017"
}
|
PMC5317073
|
A 48-year-old female presented with a pathological fracture of the right femur. 99mTc methylene diphosphonate bone scan revealed multiple areas of increased osteoblastic activity consistent with metastatic disease. Serum electrophoresis revealed monoclonal gammopathy. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) scan revealed metabolically active lesions in bulky uterine cervix and osteolytic skeletal lesions. Unusual pattern of FDG uptake in uterine cervix and osteolytic skeletal lesions warranted a biopsy of the uterine cervix which revealed diffuse large B-cell lymphoma. 18F-FDG PET/CT scan helped in guiding the site of biopsy to reach a final diagnosis in this unusual case of lymphoma with a secondary involvement of uterine cervix presenting as a pathological fracture.
|
{
"authors": [
"Erin L Youngs",
"Timothy McCord",
"Jessica A Hellings",
"Nancy B Spinner",
"Adele Schneider",
"Merlin G Butler"
],
"case_amount": 1,
"doi": "10.1002/ajmg.a.33196",
"journal": "Am J Med Genet A",
"journal_detail": "2010 Jan;152A(1):230-3.",
"keywords": null,
"license": "author_manuscript",
"link": "https://pubmed.ncbi.nlm.nih.gov/20034079/",
"major_mesh_terms": [
"Abnormalities, Multiple / genetics",
"Chromosome Aberrations",
"Chromosomes, Human, Pair 9"
],
"mesh_terms": [
"Abnormalities, Multiple / genetics",
"Chromosome Aberrations",
"Chromosomes, Human, Pair 9",
"Case Reports",
"Adolescent",
"Child",
"Child, Preschool",
"Follow-Up Studies",
"Humans",
"Infant",
"Male"
],
"pmcid": "PMC6800088",
"pmid": "20034079",
"title": "An 18-year follow-up report on an infant with a duplication of 9q34",
"year": "2010"
}
|
PMC6800088
| null |
{
"authors": [
"Eric Lombardi",
"Ryan Misek",
"Krishna Patel"
],
"case_amount": 1,
"doi": "10.1155/2018/4065342",
"journal": "Case Rep Emerg Med",
"journal_detail": "2018 Sep 23;2018:4065342.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/30345121/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC6174749",
"pmid": "30345121",
"title": "An Unusual Presentation of Acute Weakness: Acute Inflammatory Demyelinating Polyneuropathy in a Patient with Psychiatric Illness",
"year": "2018"
}
|
PMC6174749
|
We report an unusual presentation of Guillain-Barré wherein a patient with an extensive history of psychiatric illness had a dream that his legs were crushed in an earthquake and awoke from the dream with paresthesias and rapid paralysis of bilateral lower extremities. This article discusses an atypical presentation of pathology and diagnostic evaluation for a form of Guillain-Barré called Acute Inflammatory Demyelinating Polyneuropathy (AIDP).
|
{
"authors": [
"Fernando de Andrade Quintanilha Ribeiro"
],
"case_amount": 1,
"doi": "10.1016/s1808-8694(15)30764-3",
"journal": "Braz J Otorhinolaryngol",
"journal_detail": "2008 Jan-Feb;74(1):137-42.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/18392515/",
"major_mesh_terms": [
"Eustachian Tube",
"Foreign Bodies / surgery"
],
"mesh_terms": [
"Eustachian Tube",
"Foreign Bodies / surgery",
"Case Reports",
"Angiography",
"Foreign Bodies / diagnostic imaging",
"Humans",
"Male",
"Middle Aged",
"Tomography, X-Ray Computed"
],
"pmcid": "PMC9450605",
"pmid": "18392515",
"title": "Foreign body in the Eustachian tube: case presentation and technique used for removal",
"year": "2008"
}
|
PMC9450605
|
Foreign bodies of the external ear are very common; the same can not be said about foreign bodies of the middle ear, especially of the Eustachian tube.
Case presentation:
Alcoholic and psychopathic patient presented a foreign body (barbecue wooden stick) purposefully introduced in his middle ear and Eustachian tube during an act of delinquency. The foreign body was stuck in the tube and could not be removed externally. It was surgically removed as described by the authors later on in the paper.
Comments:
The patient recovered well, with no sequela on the facial nerve and without important vertigo.
|
{
"authors": [
"Edward Gologorsky",
"Francisco Igor B Macedo",
"Enisa M Carvalho",
"Angela Gologorsky",
"Marco Ricci",
"Tomas A Salerno"
],
"case_amount": 2,
"doi": "10.1155/2010/937215",
"journal": "Anesthesiol Res Pract",
"journal_detail": "2010;2010:937215.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/20798770/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC2925208",
"pmid": "20798770",
"title": "Postoperative cardiac arrest after heart surgery: does extracorporeal perfusion support a paradigm change in management?",
"year": "2010"
}
|
PMC2925208
|
Early institution of extracorporeal perfusion support (ECPS) may improve survival after cardiac arrest. Two patients sustained unexpected cardiac arrest in the Intensive Care Unit (ICU) following cardiac interventions. ECPS was initiated due to failure to restore hemodynamics after prolonged (over 60 minutes) advanced cardiac life support (ACLS) protocol-guided cardiopulmonary resuscitation. Despite relatively late institution of ECPS, both patients survived with preserved neurological function. This communication focuses on the utility of ECPS in the ICU as a part of resuscitative efforts.
|
{
"authors": [
"Koenraad De Boulle",
"Nobutaka Furuyama",
"Izolda Heydenrych",
"Terrence Keaney",
"Alexander Rivkin",
"Vincent Wong",
"Michael Silberberg"
],
"case_amount": 4,
"doi": "10.2147/CCID.S304032",
"journal": "Clin Cosmet Investig Dermatol",
"journal_detail": "2021 May 13;14:513-525.",
"keywords": [
"hyaluronic acid",
"neurotoxins",
"transgender persons"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/34012284/",
"major_mesh_terms": [],
"mesh_terms": [
"Review"
],
"pmcid": "PMC8128506",
"pmid": "34012284",
"title": "Considerations for the Use of Minimally Invasive Aesthetic Procedures for Facial Remodeling in Transgender Individuals",
"year": "2021"
}
|
PMC8128506
|
There is increasing demand among transgender individuals for minimally invasive aesthetic procedures, such as injectable facial fillers and neurotoxins, for facial remodeling and transformation. These procedures may increase transgender individuals' satisfaction with their appearance and allow them to more effectively harmonize their physical appearance with their perception of self. There is currently a lack of information in the medical literature regarding guidelines for the use of these products in transgender patients. In this report, the authors provide experience-based treatment considerations and recommendations for use of minimally invasive facial aesthetic procedures in transgender patients, including case studies illustrating the use of these procedures for both male-to-female and female-to-male transitioning patients. This report highlights the success of minimally invasive methods for assisting transgender patients in achieving their facial remodeling goals. Clinicians play an integral role in the transitioning process for transgender patients, and facial transformation is a key element of this process. When conducted with sensitivity and attention to individual patient goals at varying stages of transition, facial procedures can be of great benefit in enhancing patients' self-perception and overall quality of life.
|
{
"authors": [
"Shana Kothari",
"Tarek Almouradi"
],
"case_amount": 1,
"doi": "10.14309/crj.2018.104",
"journal": "ACG Case Rep J",
"journal_detail": "2018 Dec 19;5:e104.",
"keywords": null,
"license": "CC BY-NC-ND",
"link": "https://pubmed.ncbi.nlm.nih.gov/30643847/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC6317835",
"pmid": "30643847",
"title": "Dysphagia Caused by Cervical Plate Erosion through the Hypopharynx",
"year": "2018"
}
|
PMC6317835
| null |
{
"authors": [
"Vivek Kumar Saini",
"Alen Elias Mammoottil",
"Aftab Hassan Nazar",
"Punita Pavecha",
"Manish Ora",
"Sanjay Gambhir"
],
"case_amount": 3,
"doi": "10.4103/ijnm.ijnm_88_21",
"journal": "Indian J Nucl Med",
"journal_detail": "2022 Jan-Mar;37(1):64-67.",
"keywords": [
"staging",
"18f-fluorodeoxyglucose positron emission tomography/computed tomography",
"extranodal lymphoma",
"female genital tract",
"utero-ovarian lymphoma"
],
"license": "CC BY-NC-SA",
"link": "https://pubmed.ncbi.nlm.nih.gov/35478691/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC9037883",
"pmid": "35478691",
"title": "Utero-Ovarian Involvement in Non-Hodgkin's Lymphoma on 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography: A Case Series and Literature Review",
"year": "2022"
}
|
PMC9037883
|
Lymphomas are common solid malignancies. They are associated with substantial morbidity and mortality. Hodgkin's lymphoma (HL) and Non-HL (NHL) are subtypes of lymphoma. Lymph nodes are the most common site of involvement, though practically any organ may be involved. NHL has preponderance for extranodal involvement. Primary uterine and ovarian NHL is scarce. However, in advanced systemic disease, secondary utero-ovarian involvement may be seen. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) is a pivotal imaging modality in lymphomas. It abets in pretreatment staging, posttherapy restaging, and surveillance. We present three stage-IV NHL cases with secondary utero-ovarian involvement. FDG PET/CT as a baseline imaging modality established the disease burden and organ involvement.
|
{
"authors": [
"Maria Francesca Sfondrini",
"Maurizio Pascadopoli",
"Sergio Beccari",
"Giovanna Beccari",
"Cinzia Rizzi",
"Paola Gandini",
"Andrea Scribante"
],
"case_amount": 1,
"doi": "10.1155/2022/3100360",
"journal": "Case Rep Dent",
"journal_detail": "2022 Sep 2;2022:3100360.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/36090691/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC9463015",
"pmid": "36090691",
"title": "Orthodontic Fixed Retainer and Unwanted Movements of Lower Anterior Teeth: A Case Report",
"year": "2022"
}
|
PMC9463015
|
The use of fixed retainers at the end of an orthodontic treatment has become a standard practice. Nonetheless, orthodontic relapse can still occur, requiring retreatment in the most severe cases. This case report describes a patient with a mandibular canine to canine fixed retainer presenting uncontrolled torque on all lower anterior teeth, probably due to tongue thrust and/or activation of the wire. Multibracket orthodontic treatment was performed, and an orthodontic lingual sectional was used to control (reposition) the root movement of the lower right cuspid. This case highlights the need for clinicians and patients to be aware of the potential problems associated with bonded retainers. In addition, patients with an orthodontic fixed retainer need regular short-term observation by an orthodontist in order to detect any adverse movements and long-term control by a general dentist.
|
{
"authors": [
"W G P Kanchana",
"R A A Shaminda",
"K B Galketiya",
"V Pinto",
"D Walisinghe",
"S Wijetunge",
"R Heendeniya"
],
"case_amount": 1,
"doi": "10.1155/2016/4037618",
"journal": "Case Rep Gastrointest Med",
"journal_detail": "2016;2016:4037618.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/27747112/",
"major_mesh_terms": [],
"mesh_terms": [],
"pmcid": "PMC5055922",
"pmid": "27747112",
"title": "Laparoscopic Resection of Pancreatic Tail Solid Pseudopapillary Tumour in a Young Male",
"year": "2016"
}
|
PMC5055922
|
Background. Solid Pseudopapillary Tumours of the pancreas are a rare entity and more commonly seen in women than in men. These tumours have typically reached large sizes when clinically detected. Case Description. A 21-year-old male was found to have a left hypochondrial mass on physical examination following a trivial soft tissue injury. Contrast-enhanced computed topography (CT) of the abdomen showed a 10.3 × 7.6 × 10.3 cm size arising from the body and the tail of the pancreas. He underwent laparoscopic resection of distal pancreatic tumour en bloc with spleen. Large tumour was noted originating from the body and tail of the pancreas with dilated veins surrounding the tumour. Histology revealed a clear cell variant of solid pseudopapillary neoplasm with steatotic pattern. Resection margin was free of tumour. Discussion. Several studies have shown significant short term advantages using laparoscopic approach compared to open surgery, in terms of lower blood loss, resumption of oral intake, and hospital stay. This case and few other case reports published in world literature have shown that laparoscopic approach is safe and oncologically adequate.
|
{
"authors": [
"Enrique Sanchez-Munoz",
"Antonio Maestro Fernández",
"Iván Pipa Muñiz",
"Nicolas Rodríguez García"
],
"case_amount": 1,
"doi": "10.1155/2020/3586981",
"journal": "Case Rep Orthop",
"journal_detail": "2020 Mar 23;2020:3586981.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/32274233/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC7132354",
"pmid": "32274233",
"title": "Late-Onset Recurrent Femoral Cyst Formation 10 Years after ACL Reconstruction: A Case Report and Literature Review",
"year": "2020"
}
|
PMC7132354
|
Synovial fistula and cyst formation after anterior cruciate ligament (ACL) reconstruction is very unusual and almost always affects the tibia. Only 3 cases originating in the femur have been reported. We present a rare case of late-onset femoral cyst formation related to ACL reconstruction. Ten years after successful ACL reconstruction surgery, effusion and pain at the lateral aspect of the lateral femoral condyle appeared. Symptoms persisted despite initial percutaneous drainage and conservative treatment. Surgery was carried out, with drainage and graft-fixation pin device removal, with recurrent cyst formation after the intervention. Total recovery of the patient was achieved after carrying out revision surgery consisting in bone tunnel filling using autologous bone graft and occlusion of cortical bone defect with local fascial flap. The development of this unusual complication was related to lack of absorption of the fixation device, bone burn due to drilling, and persistent synovial fluid in the femoral bone tunnel, combined with the absence of bone ingrowth.
|
{
"authors": [
"Zackery Oakey",
"Kevin Thai",
"Sumit Garg"
],
"case_amount": 1,
"doi": "10.3205/oc000072",
"journal": "GMS Ophthalmol Cases",
"journal_detail": "2017 Aug 15;7:Doc21.",
"keywords": [
"corneal collagen crosslinking",
"keratoconus",
"visual acuity"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/28875112/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC5574252",
"pmid": "28875112",
"title": "Bilateral corneal perforation due to MRSA keratitis in a crosslinking patient",
"year": "2017"
}
|
PMC5574252
|
Introduction: The cornea may become infected and perforated after epithelium-on collagen crosslinking. Case presentation: A healthy 33-year-old male who underwent corneal collagen crosslinking in both eyes developed a purulent keratitis and bilateral corneal perforations, requiring bilateral penetrating keratoplasties. He was exposed to methicillin resistant staphylococcus aureus (MRSA) by a family member with a tracheostomy and was treated with MRSA-directed antibiotics. After prolonged recovery and treatment of his infection, he had acceptable but limited uncorrected visual acuity, with excellent corrected visual acuity. Conclusion: While epithelium-on crosslinking is commonly thought to be associated with a lower risk of postoperative infection, this case illustrates that even epithelium-on treatment may present the patient with a risk of infection. Patients in higher risk groups who are exposed to infectious disease may be more predisposed.
|
{
"authors": [
"Masashi Takeda",
"Soki Kashima",
"Yasushi Fuchigami",
"Takayuki Yoshino",
"Tatsuki R Kataoka",
"Toshinari Yamasaki",
"Hiroshi Kagamu",
"Takashi Kobayashi",
"Shusuke Akamatsu"
],
"case_amount": 1,
"doi": "10.3389/fimmu.2022.934991",
"journal": "Front Immunol",
"journal_detail": "2022 Jul 5;13:934991.",
"keywords": [
"nivolumab",
"rccu-mp",
"renal cell caecinoma",
"case report",
"immune checkpoint inhibitors",
"ipilimumab"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/35865543/",
"major_mesh_terms": [
"Carcinoma, Renal Cell"
],
"mesh_terms": [
"Carcinoma, Renal Cell",
"Case Reports",
"CD8-Positive T-Lymphocytes / pathology",
"Humans",
"Immune Checkpoint Inhibitors / therapeutic use",
"Leukocytes, Mononuclear / pathology",
"Male",
"Phenotype",
"Immune Checkpoint Inhibitors"
],
"pmcid": "PMC9294239",
"pmid": "35865543",
"title": "Case Report: A Case of Renal Cell Carcinoma Unclassified With Medullary Phenotype Exhibiting a Favorable Response to Combined Immune Checkpoint Blockade",
"year": "2022"
}
|
PMC9294239
|
Renal cell carcinoma unclassified with medullary phenotype (RCCU-MP) is an extremely rare variant of kidney cancer with poor prognosis. Recently, immune checkpoint inhibitors (ICIs) have been the mainstay of treatment for advanced clear cell renal cell carcinoma (RCC). However, the efficacy of ICI in the treatment of RCCU-MP remains unclear. Here, we report about a 63-year-old Japanese man who was referred to our hospital with a diagnosis of RCC of the left kidney with multiple-lymph node involvement (cT3aN1M1). The patient underwent nephrectomy with lymph node biopsy, which was histopathologically diagnosed as RCCU-MP. Thereafter, he received combined immune checkpoint blockade with nivolumab and ipilimumab. After induction therapy, follow-up computed tomography revealed shrinkage of the metastatic lymph nodes. Moreover, the patient was relieved of his subjective symptoms and his performance status improved. However, after 15 months, maintenance ICI therapy was discontinued because of disease progression, and the patient died 28 months after diagnosis. Longitudinal analysis of peripheral blood mononuclear cells revealed increased stem cell memory and central memory CD8+ T-cell subsets during response to therapy and enhanced expression of exhaustion markers on CD8+ T cells upon treatment resistance. Combined immune checkpoint blockade could be effective in the treatment of metastatic RCCU-MP.
|
{
"authors": [
"Catherine Cukras",
"Elvira Agrón",
"Michael L Klein",
"Frederick L Ferris 3rd",
"Emily Y Chew",
"Gary Gensler",
"Wai T Wong",
"Age-Related Eye Disease Study Research Group"
],
"case_amount": 1,
"doi": "10.1016/j.ophtha.2009.12.002",
"journal": "Ophthalmology",
"journal_detail": "2010 Mar;117(3):489-99.",
"keywords": null,
"license": "author_manuscript",
"link": "https://pubmed.ncbi.nlm.nih.gov/20079925/",
"major_mesh_terms": [
"Macular Degeneration / diagnosis",
"Retinal Detachment / diagnosis",
"Retinal Drusen / diagnosis",
"Retinal Pigment Epithelium / pathology"
],
"mesh_terms": [
"Macular Degeneration / diagnosis",
"Retinal Detachment / diagnosis",
"Retinal Drusen / diagnosis",
"Retinal Pigment Epithelium / pathology",
"Case Reports",
"Clinical Trial",
"Multicenter Study",
"Research Support, N.I.H., Intramural",
"Aged",
"Aged, 80 and over",
"Disease Progression",
"Female",
"Follow-Up Studies",
"Humans",
"Macular Degeneration / physiopathology",
"Male",
"Middle Aged",
"Prospective Studies",
"Surveys and Questionnaires",
"Visual Acuity / physiology"
],
"pmcid": "PMC2947750",
"pmid": "20079925",
"title": "Natural history of drusenoid pigment epithelial detachment in age-related macular degeneration: Age-Related Eye Disease Study Report No. 28",
"year": "2010"
}
|
PMC2947750
|
Objective:
To describe the natural history of eyes with drusenoid pigment epithelial detachments (DPEDs) associated with age-related macular degeneration (AMD).
Design:
Multicenter, clinic-based, prospective cohort study.
Participants:
Among 4757 participants enrolled in the Age-Related Eye Disease Study (AREDS), 255 were identified as having DPED in at least 1 eye and having 5 or more years of follow-up after the initial detection of the DPED.
Methods:
Baseline and annual fundus photographs were evaluated for the evolution of the fundus features and the development of advanced AMD in the forms of central geographic atrophy (CGA) or neovascular (NV) AMD. Kaplan-Meier analyses of progression to advanced AMD and of moderate vision loss (> or =15 letters compared with baseline) were performed.
Main outcome measures:
Rate of progression to advanced AMD and change in visual acuity from baseline (in terms of mean letters lost and proportion losing > or =15 letters).
Results:
A total of 311 eyes (from 255 participants) with DPED were followed for a median follow-up time of 8 years subsequent to the initial detection of a DPED. Of the 282 eyes that did not have advanced AMD at baseline, advanced AMD developed within 5 years in 119 eyes (42%) (19% progressing to CGA and 23% progressing to NV-AMD). In the remaining eyes that did not develop advanced AMD (n=163), progressive fundus changes, typified by the development of calcified drusen and pigmentary changes, were detected. Visual decline was prominent among study eyes, with approximately 40% of all eyes decreasing in visual acuity by > or =15 letters at 5 years follow-up. Mean visual acuity decreased from 76 letters ( approximately 20/30) at baseline to 61 letters ( approximately 20/60) at 5 years. Five-year decreases in mean visual acuity averaged 26 letters for eyes progressing to advanced AMD and 8 letters for non-progressing eyes.
Conclusions:
The natural history of eyes containing DPED is characterized by a high rate of progression to both CGA and NV-AMD. Among eyes not progressing to advanced AMD, progressive development of pigmentary changes and calcified drusen were observed. Decline of visual acuity is a common outcome, with or without progression to advanced forms of AMD.
|
{
"authors": [
"Ayman Qasrawi",
"Omar Abughanimeh",
"Mouhanna Abu Ghanimeh",
"Simran Arora-Elder",
"Osama Yousef",
"Tarek Tamimi"
],
"case_amount": 1,
"doi": "10.1155/2018/6939747",
"journal": "Case Reports Hepatol",
"journal_detail": "2018 Feb 26;2018:6939747.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/29682369/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC5846373",
"pmid": "29682369",
"title": "Intrahepatic Cholangiocarcinoma Masquerading as Acute Fatty Liver of Pregnancy: A Case Report and Review of the Literature",
"year": "2018"
}
|
PMC5846373
|
Cholangiocarcinoma (CCA) is an uncommon cancer and accounts only for 3% of all gastrointestinal malignancies. In this report, we present a case of an intrahepatic cholangiocarcinoma masquerading as acute fatty liver of pregnancy (AFLP). A 38-year-old female who is 36-week pregnant presented with a 1-week history of headache, nausea, vomiting, and right upper abdominal pain, along with hepatomegaly. Laboratory investigations were remarkable for mild leukocytosis, hyperbilirubinemia, proteinuria, and elevated transaminases and prothrombin time. Ultrasound of the liver revealed hepatomegaly, fatty infiltration, and a right hepatic lobe mass. Based on the overall picture, AFLP was suspected, and the patient underwent delivery by Cesarean section. However, bilirubin and liver enzyme levels gradually increased after delivery. MRI revealed a large dominant hepatic mass along with multiple satellite lesions in both lobes. Biopsy revealed the presence of intrahepatic CCA. CCA presenting during pregnancy is extremely rare with only 9 other cases reported in the literature. Therefore, the signs and symptoms can be easily confused with other more common disorders that occur during pregnancy.
|
{
"authors": [
"Jun Kakogawa",
"Miyuki Sadatsuki",
"Norio Masuya",
"Hideto Gomibuchi",
"Shigeki Minoura",
"Kazuhusa Hoshimoto"
],
"case_amount": 1,
"doi": "10.5402/2011/320246",
"journal": "ISRN Obstet Gynecol",
"journal_detail": "2011;2011:320246.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/21766037/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC3135060",
"pmid": "21766037",
"title": "Prolonged fetal bradycardia as the presenting clinical sign in congenital syphilis complicated by necrotizing funisitis: a case report",
"year": "2011"
}
|
PMC3135060
|
Syphilis remains a serious cause of neonatal morbidity and mortality worldwide. In this paper, we describe a case of congenital syphilis that was fully supported by abnormal fetal heart rate patterns and placental histopathological evidence. A 24-year-old para 4 woman, who did not attend antenatal care, was admitted to our hospital with a complaint of abdominal discomfort at an estimated 31-week gestation. Fetal heart rate monitoring showed prolonged bradycardia. A neonate weighting 1,423 g with severe birth asphyxia was immediately delivered by cesarean section. Following delivery, the mother and the neonate were diagnosed with syphilis. Histopathological examination confirmed severe chorioamnionitis and necrotizing funisitis with numerous Treponema pallidum. Conclusions. Challenges in establishing the diagnosis of necrotizing funisitis are essential for optimal management of a fetus with a systemic inflammatory response in utero.
|
{
"authors": [
"Audrey-Kristel Barbeau",
"Mariane Generale",
"Andrea Creech"
],
"case_amount": 1,
"doi": "10.3389/fpsyg.2022.878307",
"journal": "Front Psychol",
"journal_detail": "2022 Jun 30;13:878307.",
"keywords": [
"community music",
"group music-making",
"older amateur musicians",
"online music",
"pandemic (covid-19)"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/35846627/",
"major_mesh_terms": [],
"mesh_terms": [],
"pmcid": "PMC9285893",
"pmid": "35846627",
"title": "Online Group Music-Making in Community Concert Bands: Perspectives From Conductors and Older Amateur Musicians",
"year": "2022"
}
|
PMC9285893
|
At the beginning of the pandemic, many music ensembles had to stop their activities due to the confinement. While some found creative ways to start making music again with the help of technologies, the transition from "real" rehearsals to "online" rehearsals was challenging, especially among older amateur musicians. The aim of this case study was to examine the effects of this transition on three community band conductors and three older amateur musicians. Specific objectives were to explore (1) intergenerational relationships to support online group music-making; (2) digital literacy and access in later life; and (3) online music-making in a COVID-19 context. Semi-structured interviews were conducted and theoretical thematic analysis was undertaken (Braun and Clarke, 2006). Results were analyzed from the conductors' and older musicians' perspectives, and common trends were combined to facilitate interpretation. The first theme showed that being part of an intergenerational ensemble contributed positively to the learning experience online. The second theme demonstrated that because both conductors and musicians were new to the online rehearsals, it contributed to attenuate the age-related digital divide that may have been observed in other studies. Regarding access in later-life, older musicians reported benefits associated with rehearsing online, specifically in terms of distance/commute, time, energy, and cost. However, for those who did not already have internet and electronic devices, the cost of acquiring all the necessary equipment to make music online could have been too high. Finally, the third theme revealed that musicians appreciated the opportunity to make music online and indicated that it was definitely better than having nothing, especially for its social aspects. In conclusion, while participants noted several challenges associated with online music-making (e.g., zoom fatigue and technological issues), they were also appreciative of the opportunity to continue making music at a time when in-person rehearsals were not possible. Pedagogical implications are discussed, specifically the importance of the support network, of meeting people where they are, of learning to adapt, and of collaborative teaching.
|
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in Data Studio
MultiCaRe: Open-Source Clinical Case Dataset
MultiCaRe aggregates open-access, de-identified clinical case reports from PubMed Central’s OA corpus, pairing article-level metadata and abstracts with case narratives and figure images/captions. The normalization makes it easy to map from images → cases → articles.
- Source and process: parse PMC OA case reports; extract metadata/abstracts; download/process figures; align captions; build a hierarchical taxonomy for image labels.
- Scale: 85k+ OA articles, 160k+ images (v2.0).
- Tasks: article-level retrieval/classification, summarization; joins to cases/images for multimodal tasks.
- Citation: MDPI DATA paper — https://www.mdpi.com/2306-5729/10/8/123; Zenodo — https://zenodo.org/records/13936721.
This repository: per-article dataset Per-article dataset with bibliographic metadata and abstracts (one file: articles.parquet).
Schema
- article_id: PMCID (primary key)
- title, journal, year
- doi, pmid, pmcid
- mesh_terms, major_mesh_terms, keywords
- link, license, case_amount
- abstract: article abstract
Quick start
from datasets import load_dataset
art = load_dataset("openmed-community/multicare-articles", split="train")
row = art[0]
print(row["title"])
print(row["abstract"][:600])
Join examples
from datasets import load_dataset
art = load_dataset("openmed-community/multicare-articles", split="train")
cas = load_dataset("openmed-community/multicare-cases", split="train")
aid = cas[0]["article_id"]
article = art.filter(lambda e: e["article_id"] == aid)[0]
print(article["title"]) # matching article
Notes
- Use article-level splits to avoid leakage when combining with images/cases.
- Downloads last month
- 66
Size of downloaded dataset files:
74.2 MB
Size of the auto-converted Parquet files:
74.2 MB
Number of rows:
85,653