article_metadata
dict | article_id
stringlengths 8
11
| abstract
stringlengths 14
9.87k
⌀ |
|---|---|---|
{
"authors": [
"Margarida Cabral",
"Sara Fernandes",
"Catarina Ruivo",
"Hélia Martins",
"João Morais"
],
"case_amount": 1,
"doi": "10.37616/2212-5043.1348",
"journal": "J Saudi Heart Assoc",
"journal_detail": "2023 Oct 16;35(3):232-234.",
"keywords": [
"cardiac arrhythmias",
"cardiomyopathies",
"desmoplakins",
"myocarditis",
"sudden death"
],
"license": "CC BY-NC-ND",
"link": "https://pubmed.ncbi.nlm.nih.gov/37881594/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10597597",
"pmid": "37881594",
"title": "Recognizing a \"Hot Phase\" of An Arrhythmogenic Left Ventricular Cardiomyopathy: A Case Report",
"year": "2023"
}
|
PMC10597597
|
A 35-year-old male, with a medical history of acute myocarditis, presented with palpitations. Further investigation revealed non-sustained ventricular tachycardia and a slightly reduced left ventricular systolic function. Cardiac magnetic resonance showed extended late gadolinium enhancement of the left ventricle and fat infiltration. Genetic testing was positive for a pathogenic desmoplakin mutation, fulfilling the criteria of arrhythmogenic left ventricular cardiomyopathy. In conclusion, the authors described a case of a mimicked acute myocarditis at a young age in a patient with an arrhythmogenic left ventricular cardiomyopathy. Therefore, the genetic study is essential for both diagnosis and management.
|
{
"authors": [
"Mohammad Etezad-Razavi",
"Farid Shekarchian",
"Fereshteh Raoufi",
"Sahel Khazaei"
],
"case_amount": 2,
"doi": "10.4103/joco.joco_365_21",
"journal": "J Curr Ophthalmol",
"journal_detail": "2023 Aug 11;35(1):96-99.",
"keywords": [
"cholesterol granuloma",
"hematic cyst",
"orbital",
"proptosis",
"ptosis"
],
"license": "CC BY-NC-SA",
"link": "https://pubmed.ncbi.nlm.nih.gov/37680279/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10481984",
"pmid": "37680279",
"title": "Orbital Cholesterol Granuloma: Report of Two Cases",
"year": "2023"
}
|
PMC10481984
|
Purpose:
To report two rare cases of orbital cholesterol granuloma (CG) presenting with ptosis and proptosis.
Methods:
The first case was a 31-year-old male presented with progressive ptosis of the left eye (LE) during the past year and the second case was a 35-year-old male presented with proptosis of the right eye (RE) for 5 months ago. Orbital computed tomography revealed a cystic well-demarcated lesion in the superotemporal orbit with adjacent bone erosion in the LE of the first case and the RE of the second case.
Results:
In both cases, the tumor was excised completely through an anterolateral orbitotomy approach. Histopathological evaluation showed fibroconnective tissue with cholesterol clefts surrounded by granulomatous inflammation consistent with the diagnosis of CG. The symptoms of patients were resolved after surgery.
Conclusions:
CG of the orbit is a rare lesion that commonly occurred in the superotemporal area. Erosive bone expansion is the characteristic finding of this lesion that can be mistaken with lacrimal gland malignancies. Hence, it is essential to keep CG in mind in the differential diagnosis of lacrimal gland masses.
|
{
"authors": [
"Yoshihiko M Sakaguchi",
"Koichiro Murakami",
"Hiroyuki Akebo",
"Ryuichi Minoda Sada",
"Noriyuki Abe",
"Takahiro Maeda",
"Mieko Goto",
"Takashi Takahashi",
"Yusuke Takahashi",
"Eriko Kashihara",
"Jaegi Shim",
"Hirofumi Miyake",
"Kazuhiro Hatta"
],
"case_amount": 1,
"doi": "10.1016/j.idcr.2024.e01927",
"journal": "IDCases",
"journal_detail": "2024 Jan 11:35:e01927.",
"keywords": [
"empyema",
"peritonitis",
"streptococcal toxic shock syndrome",
"streptococcus pyogenes"
],
"license": "CC BY-NC-ND",
"link": "https://pubmed.ncbi.nlm.nih.gov/38303733/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10831287",
"pmid": "38303733",
"title": "Successful treatment of streptococcal toxic shock syndrome complicated by primary peritonitis and bilateral empyema in a healthy young woman: Identification of uncommon clone emm103 and novel sequence type 1363",
"year": "2024"
}
|
PMC10831287
|
Streptococcal toxic shock syndrome (STSS) has a dramatic clinical course and high mortality rate. Here, we report a case of STSS complicated by primary peritonitis and bilateral empyema. A previously healthy young woman was diagnosed with STSS complicated by primary peritonitis and bilateral empyema. Blood culture results on admission were negative. Sever shock, respiratory failure, systemic inflammation, thrombocytopenia, renal failure, ascites, and pleural effusion occurred, mimicking thrombocytopenia, anasarca, fever, reticulin fibrosis/renal failure and organomegaly (TAFRO) syndrome. Retesting blood cultures identified Streptococcus pyogenes. Gram staining of ascites and pleural fluid indicated gram-positive cocci in chains. Antibiotics, immunoglobulins, and surgical intervention led to recovery without complications. Ex-post genotypic analyses showed uncommon emm103.0 (cluster E3) of emm long sequence (784 base) and novel sequence type 1363. STSS diagnosis can be difficult as it mimics other systemic inflammatory diseases. Therefore, it is crucial for clinicians to perform microbiological examinations from infection foci, even if the initial culture is negative.
|
{
"authors": [
"Darren M C Poon",
"Lap Yin Ho",
"Yiu Ming Kwong"
],
"case_amount": 2,
"doi": "10.3389/fonc.2024.1397738",
"journal": "Front Oncol",
"journal_detail": "2024 May 28:14:1397738.",
"keywords": [
"avelumab maintenance therapy",
"case report",
"chemoradiation therapy",
"chemotherapy",
"node-positive locally advanced bladder cancer",
"urothelial carcinoma"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/38863626/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC11165194",
"pmid": "38863626",
"title": "Avelumab maintenance therapy for node-positive muscle invasive bladder cancer: a report of two cases",
"year": "2024"
}
|
PMC11165194
|
Background:
Muscle-invasive bladder cancer (MIBC) with nodal involvement is associated with poor prognosis and high mortality. Treatment of node-positive MIBC is complex due to disease heterogeneity and a lack of evidence-based treatment options, especially alternatives to radical cystectomy. We describe a bladder-sparing management approach involving systemic therapy followed by maintenance therapy, illustrated with two cases of node-positive MIBC.
Case presentation:
Two patients with node-positive MIBC received upfront gemcitabine/cisplatin chemotherapy, concurrent chemoradiotherapy (cCRT), and avelumab (immune checkpoint inhibitor) maintenance therapy. Both patients achieved complete remission without recurrence or distant metastasis post-avelumab maintenance therapy. At the last follow-up, Patient 1 (45-year-old male) was in remission for over two years, and Patient 2 (57-year-old male) was in complete remission for over one year post-chemotherapy. Avelumab treatment was well-tolerated, with no immune-related adverse events, and quality of life (QoL) was maintained.
Conclusion:
Both cases showed a good response and extended remission on avelumab maintenance, supporting its use in conjunction with local consolidation therapy as a bladder-preserving approach in node-positive MIBC. Further research, such as the ongoing INSPIRE trial, is required to refine treatment strategies for this patient group.
|
{
"authors": [
"Limin Huang",
"Xiaojing Zhang",
"Yingying Zhang",
"Yanfei Wang",
"Jianhua Mao"
],
"case_amount": 1,
"doi": "10.1159/000533580",
"journal": "Case Rep Nephrol Dial",
"journal_detail": "2023 Sep 25;13(1):148-155.",
"keywords": [
"galloway-mowat syndrome",
"lage3",
"nephrotic syndrome"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/37900929/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10601869",
"pmid": "37900929",
"title": "Novel LAGE3 Pathogenic Variants Combined with TRPC6 and NUP160 Variants in Galloway-Mowat Syndrome: A Case Report",
"year": "2023"
}
|
PMC10601869
|
Galloway-Mowat syndrome (GAMOS) is a rare autosomal recessive disorder characterized by early-onset nephrotic syndrome and microcephaly with brain anomalies in children. Researchers studying GAMOS reported the first pathogenic variant identified was the WDR73 gene, and more recently, four new pathogenic genes, OSGEP, LAGE3, TP53RK, and TPRKB, have been identified. In the present study, we report a new mutation of c.290T>G (p.L97R) LAGE3 in a 4-year-old boy with specific urological and nephrological complications. The patient presented with early-onset proteinuria, brain atrophy, delayed language and motor development, and axial hypotonia. This patient also had mutations in two other genes: TRPC6 and NUP160, make the clinical presentation of this patient more diverse. Our novel findings add to the spectrum of pathogenic variants in the LAGE3 gene. In addition, early genetic diagnosis of GAMOS is essential for genetic counseling and prenatal care.
|
{
"authors": [
"Esra Ates Bulut",
"Guzin Ozden",
"Ahmet Turan Isik"
],
"case_amount": 1,
"doi": "10.14744/nci.2022.35336",
"journal": "North Clin Istanb",
"journal_detail": "2023 Aug 4;10(4):521-523.",
"keywords": [
"aged",
"covid-19",
"angioedema",
"skin manifestations",
"urticaria"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/37719254/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10500241",
"pmid": "37719254",
"title": "An atypical presentation of COVID-19: Hidden risk for seniors to misdiagnose",
"year": "2023"
}
|
PMC10500241
|
The outbreak of coronavirus disease (COVID-19) was announced as a pandemic by the World Health Organization in March 2020. Clinical manifestations include cough, fever, dyspnea, myalgia, and loss of sense of smell and taste. Less common extrapulmonary signs and symptoms such as cutaneous manifestations, diarrhea, confusion, functional decline have been reported in the literature. Older patients with multiple comorbidities are at a greater risk for severe disease and death and are vulnerable to atypical presentations due to changes in organ systems, multimorbidity, cognitive impairment, and sensory disturbances. In this case, a 77-year-old patient diagnosed with COVID-19 pneumonia presented with atypically acute urticaria with angioedema was reported. Although there were no typical signs of the disease, such as cough or shortness of breath, the patient's laboratory values, and chest imaging were compatible with COVID-19. Therefore, the diagnosis of COVID-19 should be considered in older patients presenting with subtle signs or cutaneous manifestations.
|
{
"authors": [
"Stergos Koukias",
"Asimenia Athousaki",
"Dionisios Klonaris",
"Melina Kavousanaki",
"Georgios Papazoglou",
"Nikolaos Papanikolaou"
],
"case_amount": 1,
"doi": "10.1155/2024/6335543",
"journal": "Case Rep Otolaryngol",
"journal_detail": "2024 Sep 3:2024:6335543.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/39257960/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC11387079",
"pmid": "39257960",
"title": "Lemierre Syndrome with Extensive Thrombosis: A Unique Case Report and Literature Review",
"year": "2024"
}
|
PMC11387079
|
Background:
Lemierre syndrome (LS) is a rare complication of upper aerodigestive tract infections characterized by proximal and distal septic emboli, commonly including internal jugular vein (IJV) thrombosis. Diagnosis can be challenging, and treatment delays can result in increased patient morbidity and mortality. We present a rare case of LS with extensive thrombosis and multiple sites of distal infection and a narrative review of the literature. Case Presentation. A 52-year-old Caucasian male was transferred to the emergency department (ED) with an altered level of consciousness and clinical findings of acute bacterial pharyngotonsillitis. Medical history included cervical spine disorder and traumatic brain injury in the past, as well as the recent use of pain relievers due to acute cervical pain. Imaging studies revealed left IJV thrombosis that extended into multiple venous cerebral sinuses and infiltrates of the right lung. LS was considered the most likely diagnosis. The patient was intubated and transferred to the intensive care unit (ICU). Treatment included intravenous broad-spectrum antibiotics and anticoagulation therapy. Response to treatment was satisfactory. After extubation, he was transferred to a ward and discharged with resolution of clinical and imaging findings.
Conclusion:
LS is a rare disease and may have an insidious course. Timely diagnosis and appropriate treatment strategies, mainly broad-spectrum antibiotics, offer favorable outcomes in otherwise healthy individuals. The indications for anticoagulation therapy still remain controversial. Anticoagulants are usually administered to patients with extensive thrombosis. Surgical treatment includes abscess drainage, while IJV ligation and excision are reserved for nonresponders to medical treatment.
|
{
"authors": [
"Ying Zhang",
"Qinguo Liu",
"Deshou Ma",
"Yusufu Maimaiti",
"Zhijun Ma"
],
"case_amount": 1,
"doi": "10.21037/acr-23-192",
"journal": "AME Case Rep",
"journal_detail": "2024 Apr 7:8:47.",
"keywords": [
"papillary thyroid carcinoma (ptc)",
"case report",
"poorly differentiated thyroid carcinoma (pdtc)",
"squamous cell carcinoma subtype (scc subtype)",
"treatment"
],
"license": "CC BY-NC-ND",
"link": "https://pubmed.ncbi.nlm.nih.gov/38711906/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC11071005",
"pmid": "38711906",
"title": "The coexistence of papillary thyroid carcinoma, anaplastic thyroid carcinoma (squamous cell carcinoma subtype) and poorly differentiated thyroid carcinoma: a case report",
"year": "2024"
}
|
PMC11071005
|
Background:
Papillary thyroid carcinoma (PTC) accounts for about 60% of adult thyroid carcinoma and generally has an excellent prognosis. Primary squamous cell carcinoma of thyroid (PSCCT) is a rare thyroid tumor with high malignancy and poor prognosis. In 2022, the 5th edition of World Health Organization (WHO) has classified it as a subtype of anaplastic thyroid carcinoma (ATC), abbreviated as ATC-squamous cell carcinoma (SCC) subtype. Poorly differentiated thyroid carcinoma (PDTC) is a kind of follicular-derived malignancy, which is prone to recurrence and distant metastasis. Here, we report a rare case of the coexistence of PTC, ATC-SCC subtype and PDTC.
Case description:
We herein report a case of 69-year-old female who initially presented with a history of left neck mass for one month. Comprehensive auxiliary examinations and postoperative pathology confirmed the diagnosis of PTC combined with ATC-SCC subtype, and PDTC. Total thyroidectomy with radical left cervical lymph node dissection was performed, followed by thyroid-stimulating hormone (TSH) suppressive therapy, 131I, radiotherapy and chemotherapy. The patient showed no tumor recurrence or metastasis after a 5-month postoperative follow-up.
Conclusions:
The simultaneous occurrence of PTC, ATC-SCC subtype, and PDTC is extremely rare in clinical terms or literature reports. The treatment has not been standardized, and early radical surgery is the first choice. In addition, the combination of adjuvant therapies such as TSH suppressive therapy, radiotherapy, chemotherapy and 131I may further improve the prognosis of the patient.
|
{
"authors": [
"Simon Arvin",
"Khalil Ahmad",
"Mariann Tang",
"Gratien Andersen",
"Bjarne Linde Nørgaard"
],
"case_amount": 1,
"doi": "10.21037/acr-22-107",
"journal": "AME Case Rep",
"journal_detail": "2023 Oct 13:7:42.",
"keywords": [
"case report",
"aortic dissection",
"conservative treatment",
"surgery",
"therapy adherence"
],
"license": "CC BY-NC-ND",
"link": "https://pubmed.ncbi.nlm.nih.gov/37942037/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10628417",
"pmid": "37942037",
"title": "Conservative treatment of type A aortic dissection: a case report with 5 years of follow-up",
"year": "2023"
}
|
PMC10628417
|
Background:
Acute aortic dissection causes major morbidities and mortalities. The treatment of choice for type A aortic dissection (TAAD) is emergent surgical intervention. However, surgery per se may be associated with significant risk, in part due to the general surgical challenges, and the inherent hemodynamic- and organ malperfusion effects. In particular, surgery correlates with marked perioperative mortality in octo- and nonagenarians and those with severe comorbidities. Conservative medical treatment represents an alternative approach to patients for whom surgery is deemed high-risk, but case literature in this field remains sparse.
Case description:
We present a case of an 86-year-old female admitted with TAAD and deemed inoperable by the cardiothoracic surgical team due to excessive risks. The patient was treated conservatively with an extensive and aggressive antihypertensive regimen, leading to an uneventful recovery.
Conclusions:
Most cases of TAADs require emergent surgery. However, surgery is often contraindicated in comorbid and older patients due to excessive risks. The patient in this report is unique due to the long follow-up after conservative treatment and the close adherence to treatment protocol due to continuous therapeutic monitoring. It is important to consider factors for and against conservative therapeutic strategies, and, importantly, adherence to such should be carefully monitored to optimize patient outcomes.
|
{
"authors": [
"Kiran Malbul",
"Ashish Prasad Rajbhandari"
],
"case_amount": 1,
"doi": "10.1016/j.ijscr.2023.109206",
"journal": "Int J Surg Case Rep",
"journal_detail": "2024 Jan:114:109206.",
"keywords": [
"diagnostic challenges",
"femoral hernia",
"imaging limitations",
"inguinal hernia repair",
"recurrent hernia",
"surgical exploration"
],
"license": "CC BY-NC-ND",
"link": "https://pubmed.ncbi.nlm.nih.gov/38176279/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10791563",
"pmid": "38176279",
"title": "From inguinal to giant femoral hernia: An unusual postoperative twist - A rare case report",
"year": "2024"
}
|
PMC10791563
|
Introduction and importance:
Femoral hernias following inguinal hernia repairs are an unusual occurrence that presents diagnostic challenges for healthcare providers. Surgical repair of inguinal hernias is generally successful, but complications and recurrence can arise. The coexistence of femoral hernias following inguinal hernia repairs is rare, requiring careful evaluation and management.
Case presentation:
A middle-aged patient sought medical attention with complaints of recurrent groin pain and a palpable bulge in the inguinal region. Initial imaging studies, including ultrasonography and contrast-enhanced computed tomography (CT), pointed towards an inguinal hernia, leading to the scheduling of surgical repair. However, during the operation, the surgeon discovered a femoral hernia, highlighting the limitations of imaging techniques in accurately diagnosing these hernia types.
Clinical discussion:
Due to anatomical variations and overlapping signs and symptoms, distinguishing between femoral and inguinal hernias can be challenging. Scar tissue from previous inguinal hernia repairs can further complicate imaging interpretations. Intraoperative exploration becomes crucial to confirm the diagnosis and facilitate proper surgical repair.
Conclusion:
The reported case emphasizes the importance of maintaining vigilance in evaluating patients with suspected hernias, particularly those with prior inguinal hernia repairs. Relying solely on imaging studies can lead to misdiagnosis, as illustrated by the discovery of a femoral hernia during surgery. Healthcare providers should be aware of the possibility of femoral hernias and conduct comprehensive evaluations to ensure timely intervention and improve patient outcomes. Further research and awareness are essential to optimize the care of such uncommon clinical scenarios.
|
{
"authors": [
"Benjamin Morat",
"Nadine Lucidarme",
"Auriane Gibert",
"Carole Harbulot",
"Noémie Lachaume",
"Stéphanie Gréteau",
"Romain Basmaci"
],
"case_amount": 1,
"doi": "10.3389/fped.2023.1245861",
"journal": "Front Pediatr",
"journal_detail": "2023 Dec 20:11:1245861.",
"keywords": [
"covid-19",
"hba1c",
"sars-cov-2",
"children",
"diabetes mellitus",
"hypoglycemia",
"lockdown",
"pediatrics"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/38188912/",
"major_mesh_terms": [],
"mesh_terms": [],
"pmcid": "PMC10769491",
"pmid": "38188912",
"title": "Impact of lockdown on children with type-1 diabetes: returning to the community was associated with a decrease in HbA1c",
"year": "2023"
}
|
PMC10769491
|
Background:
In March 2020, a 2-month lockdown of the entire population has been declared in France to limit the spread of COVID-19. Sudden changes in daily life can impact the glycemic control of patients with type 1 diabetes (T1D), especially children and adolescents. We aimed to assess the impact of the lockdown on glycemic control in children and adolescents with T1D.
Methods:
Children with T1D were prospectively recruited in two pediatric centers from May 11 to August 1, 2020. At inclusion, patients and/or parents were asked to fill in a form assessing the patient's lifestyle during the lockdown and a medical case report form was filled in by clinician. The mean of the three last glycated hemoglobin (HbA1c) values obtained before lockdown (HbA1c_mean; before March 17, 2020) was compared to the first HbA1c value measured after the lockdown (HbA1c_after; from May 11 to August 1, 2020). Univariable and multivariable analyses were performed, as appropriate, to identify factors associated with glycemic changes during lockdown.
Results:
One-hundred-and-eighteen children and adolescents (median age was 14.1 years, 50% males) with T1D (median time from diagnosis was 4.1 years) were enrolled in the study. No significant difference was observed between medians of HbA1c_mean and HbA1c_after values (8.37% [7.88; 9.32%] vs. 8.50% [7.70; 9.50%], respectively; p = 0.391). Returning to the community was a protective factor [OR 0.31 (0.09-0.94); p = 0.045]. Patients having increased HbA1c were more frequently in contact with a suspected case of COVID-19 [OR 9.07 (2.15-53.66); p = 0.006], whereas patients having decreased HbA1c had the feeling of increase number of hypoglycemia [OR 0.19 (0.05-0.57); p = 0.006].
Conclusion:
In our patients, HbA1c before and after the lockdown was stable. In subgroup analysis, returning to the community was a protective factor. In addition, feeling of hypoglycemia was more frequent in the patients with decreased HbA1c.
|
{
"authors": [
"Kai Peng",
"Yuhua Li",
"Hao Su",
"Chenlu Lan",
"Zaida Huang",
"Yongguang Wei",
"Xiwen Liao",
"Minhao Peng",
"Tao Peng",
"Guangzhi Zhu"
],
"case_amount": 1,
"doi": "10.3389/fimmu.2023.1325445",
"journal": "Front Immunol",
"journal_detail": "2023 Dec 15:14:1325445.",
"keywords": [
"case report",
"colorectal cancer liver metastasis",
"conversion therapy",
"hepatic arterial infusion chemotherapy",
"interventional therapy"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/38173715/",
"major_mesh_terms": [
"Carcinoma, Hepatocellular / pathology",
"Colorectal Neoplasms / pathology",
"Liver Neoplasms / pathology"
],
"mesh_terms": [
"Carcinoma, Hepatocellular / pathology",
"Colorectal Neoplasms / pathology",
"Liver Neoplasms / pathology",
"Case Reports",
"Research Support, Non-U.S. Gov't",
"Aged",
"Fluorouracil",
"Hepatic Artery / pathology",
"Humans",
"Male",
"sintilimab",
"lenvatinib",
"Fluorouracil"
],
"pmcid": "PMC10762641",
"pmid": "38173715",
"title": "Case report: hepatic arterial infusion chemotherapy combined with sintilimab and lenvatinib for conversion therapy of colorectal cancer liver metastases",
"year": "2023"
}
|
PMC10762641
|
Background:
Liver metastasis is one of the most common causes of death in patients with colorectal cancer. Therefore, improving the treatment effect of liver metastatic carcinoma of colorectal cancer is also one of the effective ways to improve the survival time of patients with colorectal cancer. The main treatment method for liver metastasis of colorectal cancer is preoperative neoadjuvant chemotherapy through intravenous administration. However, no one has reported a conversion therapy approach for the treatment of colorectal cancer liver metastases patients through arterial infusion chemotherapy combined with targeted agents and PD-1 monoclonal antibody. This case reports a conversion therapy method of liver metastases of colorectal cancer by hepatic arterial infusion chemotherapy (HAIC), sintilimab injection combined with lenvatinib to achieve radical resection of liver metastatic carcinoma after treatment.
Case presentation:
The patient was a 69-year-old man who had previously undergone laparoscopic left hemicolectomy for descending colorectal cancer and multiple interventional and surgical treatments for hepatocellular carcinoma. During this treatment, the patient underwent radiological and serological tests, and primary liver cancer was considered at the initial diagnosis stage. Therefore, this liver malignant tumor lesion was treated according to the primary liver cancer treatment protocol before surgical resection. Therefore, the patient received HAIC combined with sintilimab injection and lenvatinib. After three treatment cycles, radiological examination showed no obvious tumor activity, alpha-fetoprotein (AFP) decreased to normal, protein induced by vitamin K absence or antagonist II (PIVKA II) decreased significantly, and the curative effect was evaluated as complete remission. Subsequently, we performed surgical resection of this liver lesion. The pathological response of left lobe tumor was partial remission (PR). Most of the tumors were necrotic and the necrosis rate was greater than 95%. A small amount of live tumor tissue remains (<5%). The pathological classification of this tumor was confirmed as moderately differentiated adenocarcinoma by immunohistochemical staining of multiple tumor indicators in the pathology department. No significant adverse drug events were observed in this patient during treatment.
Conclusion:
Hepatic arterial infusion chemotherapy combined with sintilimab injection and lenvatinib conversion therapy provides the opportunity for radical surgical resection of colorectal cancer liver metastases.
|
{
"authors": [
"Yixing Huang",
"Ahmed Gomaa",
"Sabine Semrau",
"Marlen Haderlein",
"Sebastian Lettmaier",
"Thomas Weissmann",
"Johanna Grigo",
"Hassen Ben Tkhayat",
"Benjamin Frey",
"Udo Gaipl",
"Luitpold Distel",
"Andreas Maier",
"Rainer Fietkau",
"Christoph Bert",
"Florian Putz"
],
"case_amount": 1,
"doi": "10.3389/fonc.2023.1265024",
"journal": "Front Oncol",
"journal_detail": "2023 Sep 14:13:1265024.",
"keywords": [
"gray zone",
"artificial intelligence",
"clinical decision support (cds)",
"large language model",
"natural language processing",
"radiotherapy"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/37790756/",
"major_mesh_terms": [],
"mesh_terms": [],
"pmcid": "PMC10543650",
"pmid": "37790756",
"title": "Benchmarking ChatGPT-4 on a radiation oncology in-training exam and Red Journal Gray Zone cases: potentials and challenges for ai-assisted medical education and decision making in radiation oncology",
"year": "2023"
}
|
PMC10543650
|
Purpose:
The potential of large language models in medicine for education and decision-making purposes has been demonstrated as they have achieved decent scores on medical exams such as the United States Medical Licensing Exam (USMLE) and the MedQA exam. This work aims to evaluate the performance of ChatGPT-4 in the specialized field of radiation oncology.
Methods:
The 38th American College of Radiology (ACR) radiation oncology in-training (TXIT) exam and the 2022 Red Journal Gray Zone cases are used to benchmark the performance of ChatGPT-4. The TXIT exam contains 300 questions covering various topics of radiation oncology. The 2022 Gray Zone collection contains 15 complex clinical cases.
Results:
For the TXIT exam, ChatGPT-3.5 and ChatGPT-4 have achieved the scores of 62.05% and 78.77%, respectively, highlighting the advantage of the latest ChatGPT-4 model. Based on the TXIT exam, ChatGPT-4's strong and weak areas in radiation oncology are identified to some extent. Specifically, ChatGPT-4 demonstrates better knowledge of statistics, CNS & eye, pediatrics, biology, and physics than knowledge of bone & soft tissue and gynecology, as per the ACR knowledge domain. Regarding clinical care paths, ChatGPT-4 performs better in diagnosis, prognosis, and toxicity than brachytherapy and dosimetry. It lacks proficiency in in-depth details of clinical trials. For the Gray Zone cases, ChatGPT-4 is able to suggest a personalized treatment approach to each case with high correctness and comprehensiveness. Importantly, it provides novel treatment aspects for many cases, which are not suggested by any human experts.
Conclusion:
Both evaluations demonstrate the potential of ChatGPT-4 in medical education for the general public and cancer patients, as well as the potential to aid clinical decision-making, while acknowledging its limitations in certain domains. Owing to the risk of hallucinations, it is essential to verify the content generated by models such as ChatGPT for accuracy.
|
{
"authors": [
"Adnan Alkurdi",
"Johannes Herrmann",
"Damir Bikmukhametov",
"Rebecca Tschöpe"
],
"case_amount": 1,
"doi": "10.1159/000537957",
"journal": "Case Rep Gastroenterol",
"journal_detail": "2024 May 10;18(1):260-265.",
"keywords": [
"biliary cast syndrome",
"cholestasis",
"icu",
"secondary sclerosing cholangitis"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/38737441/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC11087035",
"pmid": "38737441",
"title": "Biliary Cast Syndrome and Secondary Sclerosing Cholangitis in Critically Ill Patient after Long-Term Treatment in the Intensive Care Unit",
"year": "2024"
}
|
PMC11087035
|
Introduction:
Secondary sclerosing cholangitis in critically ill patients (SSC-CIP) is a rare but underdiagnosed entity that occurs after life-threatening events and treatment in the intensive care unit (ICU). The etiology of SSC-CIP is not fully understood but may be caused by ischemic bile duct injury. SSC-CIP is a cholestatic liver disease that rapidly progresses to liver cirrhosis, with a high mortality rate in the first year of 50%. Endoscopic retrograde cholangiopancreatography (ERCP), which is the gold standard for diagnosing SSC-CIP, shows primary SC-like changes, usually in the intrahepatic bile ducts. Biliary cast formation is pathognomonic for SSC-CIP. No proven effective conservative treatment is available for SSC-CIP, and liver transplantation is the only curative therapy when liver cirrhosis or recurrent cholangitis occurs.
Case presentation:
We report the case of a 47-year-old male patient who developed cholestasis after a long treatment in the ICU for severe pneumonia. ERCP showed characteristic findings with rarefication and multiple segmental stenosis in the intrahepatic bile ducts. We removed multiple biliary casts from the bile ducts.
Conclusion:
SSC-CIP should be considered for ICU patients with unclear cholestasis, especially when the cholestasis persists after recovery from the underlying disease. Early diagnosis is important to achieve better outcomes; without liver transplantation, the prognosis is generally poor.
|
{
"authors": [
"Junya Tatezuki",
"Sujong Pak",
"Fukutaro Ohgaki",
"Yasunori Takemoto",
"Yasuhiko Mochimatsu"
],
"case_amount": 1,
"doi": "10.2176/jns-nmc.2023-0220",
"journal": "NMC Case Rep J",
"journal_detail": "2024 Feb 14:11:37-41.",
"keywords": [
"acute subdural hematoma",
"convexity",
"dural arteriovenous fistula",
"transarterial embolization"
],
"license": "CC BY-NC-ND",
"link": "https://pubmed.ncbi.nlm.nih.gov/38454912/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10917653",
"pmid": "38454912",
"title": "Convexity Dural Arteriovenous Fistula without Cortical Venous Reflux Presenting with Pure Acute Subdural Hematoma",
"year": "2024"
}
|
PMC10917653
|
Hemorrhagic changes in a dural arteriovenous fistula are typically associated with cortical venous reflux and occur as intracerebral or subarachnoid hemorrhages. A convexity dural arteriovenous fistula (DAVF) usually flows directly into the cortical veins and exhibits cortical venous reflux. Herein, we report a rare case of a convexity DAVF without cortical venous reflux presenting with a pure acute subdural hematoma. A 19-year-old man complaining of headache without any history of head injury was diagnosed with a left acute subdural hematoma on magnetic resonance imaging (MRI) and referred to our hospital. The patient was conscious and exhibited no neurological signs. The MRI did not reveal any possible abnormalities leading to hemorrhage. Cerebral angiography revealed a dural arteriovenous fistula in the left parietal cranium with a feeder from the middle meningeal artery and a drainer into the main transverse sinus via a diploic vein. Part of the shunt blood flowed into the superior sagittal sinus from the meningeal vein; however, there was no reflux into the cortical vein or stasis of the cerebral vein, suggesting venous hypertension. A convexity DAVF was diagnosed as the source of bleeding, and transarterial embolization was performed. The patient recovered without any neurological deficits. In the absence of trauma, an acute subdural hematoma requires an appropriate evaluation of the vascular lesions and a treatment plan.
|
{
"authors": [
"Harjit Singh",
"Alexandra Kimchy",
"Camille Boustani",
"Mfoniso Umoren",
"Amol Rangnekar",
"Coleman Smith"
],
"case_amount": 1,
"doi": "10.1155/2023/7094924",
"journal": "Case Reports Hepatol",
"journal_detail": "2023 Dec 31:2023:7094924.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/38187994/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10771916",
"pmid": "38187994",
"title": "Hemorrhagic Shock from a Duodenal Ulcer Eroding into an Ectopic Varix",
"year": "2023"
}
|
PMC10771916
|
Ectopic varices are an infrequent yet fatal complication resulting from the progression of liver cirrhosis. Duodenal varices pose a significant challenge to clinicians as they are not easily visualized on endoscopy due to their submucosal location and lack of red color signs. Identification of duodenal varices is important given the risk of massive and life-threatening bleeding that is difficult to control. Patients may present in hemorrhagic shock requiring immediate resuscitation; however, confirmation of the bleeding source as variceal or non-variceal is critical in determining the optimal therapeutic intervention. Here, we report an unusual case of a duodenal ulcer that eroded into an ectopic varix resulting in hemorrhagic shock.
|
{
"authors": [
"Hema Yamini Ramarmuty",
"Nai-Chien Huan",
"Larry Ellee Nyanti",
"Teng Shin Khoo",
"Tamilarasi Renganathan",
"Ahmad Zaki Manoh",
"Nusaibah Azman",
"Kunji Kannan Sivaraman Kannan"
],
"case_amount": 4,
"doi": "10.1177/17534666241231122",
"journal": "Ther Adv Respir Dis",
"journal_detail": "2024 Jan-Dec:18:17534666241231122.",
"keywords": [
"case series",
"cryobiopsy",
"endobronchial ultrasound",
"mediastinal lymphadenopathy"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/38357899/",
"major_mesh_terms": [
"Lung Neoplasms / diagnosis",
"Lung Neoplasms / pathology",
"Silicosis",
"Tuberculosis"
],
"mesh_terms": [
"Lung Neoplasms / diagnosis",
"Lung Neoplasms / pathology",
"Silicosis",
"Tuberculosis",
"Case Reports",
"Bronchoscopy / methods",
"Endoscopic Ultrasound-Guided Fine Needle Aspiration / methods",
"Humans",
"Malaysia",
"Mediastinum / diagnostic imaging",
"Mediastinum / pathology",
"Retrospective Studies"
],
"pmcid": "PMC10870810",
"pmid": "38357899",
"title": "Early experience of endobronchial ultrasound-guided transbronchial nodal cryobiopsy: a case series from Sabah, Malaysia",
"year": "2024"
}
|
PMC10870810
|
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is an established minimally invasive method for the diagnosis of benign and malignant conditions. Continuous efforts are underway to improve the material adequacy of EBUS-TBNA, including the introduction of a new technique called EBUS-guided transbronchial nodal cryobiopsy (EBUS-TBNC). This method allows for the retrieval of larger and well-preserved histologic samples from the mediastinum. We present a case series of four patients who underwent combined EBUS-TBNA and EBUS-TBNC procedures in our centre. All procedures were performed under general anaesthesia using a convex probe EBUS scope (Pentax EB-1970UK). Two patients were diagnosed with malignancy and two with benign disorders (silicosis and tuberculosis). In the malignant cases, both EBUS-TBNA/cell block and cryobiopsy provided a diagnosis but cryobiopsy yielded more material for ancillary tests in one patient. However, in the benign cases, there was discordance between EBUS-TBNA/cell block and cryobiopsy. Only cryobiopsy detected granuloma in the patient with TB (tuberculosis), and in the patient with silicosis, TBNC provided a better overall histological evaluation, leading to a definitive diagnosis. No complications were observed. This case series supports the potential diagnostic value of combining EBUS-TBNA and EBUS-TBNC, particularly in benign mediastinal lesions (granulomatous diseases), and in cases requiring additional molecular tests in cancer diagnosis.
|
{
"authors": [
"P Arathi",
"K Sreejith",
"K Pavithran",
"Devipriya Soman"
],
"case_amount": 1,
"doi": "10.1016/j.jaim.2024.100899",
"journal": "J Ayurveda Integr Med",
"journal_detail": "2024 Jan-Feb;15(1):100899.",
"keywords": [
"ayurveda",
"case report",
"chemotherapy",
"insomnia",
"integrative oncology",
"kshirabala"
],
"license": "CC BY-NC-ND",
"link": "https://pubmed.ncbi.nlm.nih.gov/38377655/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10885578",
"pmid": "38377655",
"title": "Integrative management of insomnia during cancer chemotherapy: A case report",
"year": "2024"
}
|
PMC10885578
|
Introduction:
Insomnia is common among cancer patients, affecting about 50% undergoing cancer treatment. Insomnia can be due to various reasons, such as physical-pain, psychological-distress and medication side-effects. Insomnia has significant impact on quality of life of cancer patients. Even-though managed with hypnotics and antipsychotic drugs, they cause dependency with various short-term and long-term complications. Presenting a case throwing light on Ayurveda topical intervention as add-on to standard-of-care in insomnia during cancer chemotherapy.
Method:
A 51-year-old female patient with breast-cancer with extensive necrosis extending to subcutaneous areas was due for second cycle chemotherapy and was diagnosed with moderate-insomnia with a score of 21 as per Insomnia Severity Index in the Out-Patient-Department. Quality of sleep was assessed using Pittsburgh-Sleep-Quality-Index. Treated for 14 days during the break between cycle two and cycle three with Shirothalam (applied on the vertex) using Kachuradi Churnam with Kshirabala 101 and Padabhyangam (foot massage) using Kshirabala thailam as add-on to Tab Zolpidem5mg. Assessment was conducted on baseline and after 14 days of intervention.
Results:
Assessment for insomnia before and after intervention was conducted with Insomnia-Severity-Index. The score improved from 21 to 2. Quality of sleep before and after intervention was assessed using global PSQI. It improved from 20 to 8.
Discussion:
In Ayurveda, Nidranasam (loss of sleep) results from aggravation of Vata-Pitta (body humors responsible for movement and cognition and digestion, metabolism and heat of body), depletion of Kapha (body humor responsible for structural cohesion of body), derangement of Manasika-Dosa (mental constituents) and other diseases. All these etiological factors are attributed by Tikshna(sharp)- Uṣhna(hot potency) and Ruksha(dry) chemotherapy regimens. Vata-Pitta-hara (normalising Vata and Pitta) and Indriyaprasadaka (clearing senses) action of medicines used could induce sleep and effectively improve quality of sleep.
Conclusion:
Integrative-intervention was found to be beneficial in improving insomnia and quality of sleep without any reported complications or dependency in this case. After 14 days of ayurvedic intervention, the patient could get sleep even without taking zolpidem 5mg and external therapies. Same protocol could be considered for generalization so that it could modify or reduce usage of hypnotics and antipsychotic-drugs.
|
{
"authors": [
"Zhichen Wei",
"Linlin Shao",
"Shuqian Xu",
"Xiaolin Zhang",
"Lin Wang",
"Ping Qin",
"Qiang Song",
"Ming Hou",
"Yan Shi"
],
"case_amount": 1,
"doi": "10.3389/fonc.2024.1460557",
"journal": "Front Oncol",
"journal_detail": "2024 Sep 4:14:1460557.",
"keywords": [
"acute myeloid leukemia",
"acute promyelocytic leukemia",
"all-trans retinoic acid",
"azacitidine",
"nucleoporin 98-retinoic acid receptor gamma"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/39296977/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC11408469",
"pmid": "39296977",
"title": "Case report: Successful therapy with azacitidine for acute myeloid leukemia with NUP98::RARG resembling acute promyelocytic leukemia",
"year": "2024"
}
|
PMC11408469
|
We report a case of acute myeloid leukemia (AML) with retinoic acid receptor gamma (RARG) rearrangement, exhibiting clinical, morphological, and immunophenotypic features similar to classic acute promyelocytic leukemia (APL). RNA sequencing analysis of the patient's bone marrow samples revealed the presence of nucleoporin 98 (NUP98)-RARG caused by translocation. AML with RARG rearrangement is insensitive to all-trans retinoic acid (ATRA) and arsenic trioxide. The patient received azacitidine therapy after failing ATRA and standard 3 + 7 therapy (idarubicin and cytarabine) and achieved complete remission. Conclusively, this acute myeloid leukemia subtype may benefit from azacitidine.
|
{
"authors": [
"Kabsoo Shin",
"Ryul Kim",
"Hansol Park",
"Wonchul Lee",
"Sangmoon Lee",
"Joonoh Im",
"Ji Eun Lee",
"Sung Hun Kim",
"Erin Connolly-Strong",
"Young Seok Ju",
"Brian Baek-Lok Oh",
"Jeongmin Lee"
],
"case_amount": 4,
"doi": "10.1159/000536087",
"journal": "Case Rep Oncol",
"journal_detail": "2024 Feb 23;17(1):317-328.",
"keywords": [
"breast cancer",
"comprehensive genomic profiling",
"whole-genome sequencing"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/38404405/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10890799",
"pmid": "38404405",
"title": "Clinical Utility of Whole-Genome Analysis as One-for-All Test for Breast Cancer: A Case Series",
"year": "2024"
}
|
PMC10890799
|
Introduction:
Breast cancer exhibits vast genomic diversity, leading to varied clinical manifestations. Integrating molecular subtyping with in-depth genomic profiling is pivotal for informed treatment choices and prognostic insights. Whole-genome clinical analysis provides a holistic view of genome-wide variations, capturing structural changes and affirming tumor suppressor gene loss of heterozygosity.
Case presentation:
Here we detail four unique breast cancer cases from Seoul St. Mary's Hospital, highlighting the actionable benefits and clinical value of whole-genome sequencing (WGS). As an all-in-one test, WGS demonstrates significant clinical utility in these cases, including: (1) detecting homologous recombination deficiency with underlying somatic causal variants (case 1), (2) distinguishing double primary cancer from metastasis (case 2), (3) uncovering microsatellite instability (case 3), and (4) identifying rare germline pathogenic variants in TP53 gene (case 4). Our observations underscore the enhanced clinical relevance of WGS-based testing beyond pinpointing a few driver mutations in conventional targeted panel sequencing platforms.
Conclusion:
With genomic advancements and decreasing sequencing costs, WGS stands out as a transformative tool in oncology, paving the way for personalized treatment plans rooted in individual genetic blueprints.
|
{
"authors": [
"Chaowen Deng",
"Kelvin Hei-Yeung Chiu",
"Nan Lou",
"Fanfan Xing"
],
"case_amount": 1,
"doi": "10.3389/fmed.2023.1322993",
"journal": "Front Med (Lausanne)",
"journal_detail": "2024 Jan 9:10:1322993.",
"keywords": [
"listeria monocytogenes",
"case report",
"prosthetic joint infection",
"rheumatoid arthritis",
"tofacitinib"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/38264038/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10803402",
"pmid": "38264038",
"title": "Case report: Occult Listeria monocytogenes invasion leading to prosthetic hip joint infection in a patient with rheumatoid arthritis taking tofacitinib",
"year": "2024"
}
|
PMC10803402
|
It has been suggested that targeted therapy may potentially increase the risk of listeriosis. However, no reported cases of Listeria monocytogenes prosthetic joint infection have been documented during Janus Kinase (JAK) pathway inhibitor use. Herein, we present a 70-year-old female with rheumatoid arthritis who had undergone bilateral hip joint replacement and subsequently developed Listeria monocytogenes prosthetic joint infection following tofacitinib therapy. We suggest that the use of tofacitinib may potentially heighten susceptibility to listeriosis in patients afflicted with rheumatoid arthritis.
|
{
"authors": [
"Badr Kabila",
"Basma Beqqali",
"Samia Obilat",
"Siham El Haddad",
"Nazik Allali",
"Latifa Chat"
],
"case_amount": 1,
"doi": "10.1177/2333794X231219168",
"journal": "Glob Pediatr Health",
"journal_detail": "2023 Dec 25:10:2333794X231219168.",
"keywords": [
"brown tumor",
"neurofibromatosis type i",
"secondary hyperparathyroidism"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/38149086/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10750510",
"pmid": "38149086",
"title": "Mandibular Brown Tumor Revealing Hyperparathyroidism in a Patient With Neurofibromatosis Type I: Case Report",
"year": "2023"
}
|
PMC10750510
|
The brown tumor is a non-neoplastic lesion resulting from an abnormality in bone metabolism in the context of primary, secondary, or tertiary hyperparathyroidism. They can affect any bone structure and be single or multiple. They are usually located on the long bones, pelvis, ribs, and collarbones. Facial localization is rare and is found in only 4.5% of brown tumors dominated by mandibular involvement. The treatment of a brown tumor depends on several elements: etiology, location, and symptomatology. It can regress or disappear after the treatment of hyperparathyroidism, thus avoiding surgical removal. Otherwise, excision of this mass is performed. We illustrate through this case a brown mandibular tumor revealing secondary hyperparathyroidism in a patient with a history of end-stage chronic renal failure on hemodialysis and associated neurofibromatosis type 1.
|
{
"authors": [
"Norbert Svoboda",
"Jozef Malik",
"Frantisek Charvat",
"David Netuka"
],
"case_amount": 1,
"doi": "10.1159/000533832",
"journal": "Case Rep Neurol",
"journal_detail": "2023 Sep 4;15(1):215-221.",
"keywords": [
"aneurysm",
"cerebral revascularization",
"stents"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/37901130/",
"major_mesh_terms": [],
"mesh_terms": [],
"pmcid": "PMC10601690",
"pmid": "37901130",
"title": "Transcirculation Approach for Matricidal Carotid Cavernous Aneurysm: Not a Good Choice - A Case Report of Unsuccessful Endovascular Treatment of Matricidal Carotid Cavernous Aneurysm",
"year": "2023"
}
|
PMC10601690
|
Matricidal carotid cavernous aneurysm (CCA) is a rare and dangerous condition. The treatment failure of the endovascular approach like flow diversion, coiling, or stent-coiling is relatively high with considerable morbidity and mortality. The transcirculation approach is an alternative treatment option, but in case of matricidal CCAs, the results are not well documented in the literature. The authors present a complicated case of an unsuccessful transcirculation approach for matricidal CCA finally treated with sacrifice of the parent artery and high-flow bypass.
|
{
"authors": [
"Adriana Amaral Carvalho",
"Renato Assis Machado",
"Célia Márcia Fernandes Maia",
"Luis Antônio Nogueira Dos Santos",
"Daniella Reis Barbosa Martelli",
"Ricardo Della Coletta",
"Hercílio Martelli Júnior"
],
"case_amount": 1,
"doi": "10.1590/1984-0462/2024/42/2022189",
"journal": "Rev Paul Pediatr",
"journal_detail": "2024 May 27:42:e2022189.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/38808865/",
"major_mesh_terms": [
"Lamin Type A / genetics",
"Mutation, Missense",
"Phenotype"
],
"mesh_terms": [
"Lamin Type A / genetics",
"Mutation, Missense",
"Phenotype",
"Case Reports",
"Acro-Osteolysis",
"Child",
"Female",
"Humans",
"Lipodystrophy",
"Mandible / abnormalities",
"Mandible / diagnostic imaging",
"Lamin Type A",
"LMNA protein, human",
"Mandibuloacral dysplasia with type A lipodystrophy"
],
"pmcid": "PMC11135898",
"pmid": "38808865",
"title": "A rare LMNA missense mutation causing a severe phenotype of mandibuloacral dysplasia type A: a case report",
"year": "2024"
}
|
PMC11135898
|
Objective:
To report the case of a girl presenting a severe phenotype of mandibuloacral dysplasia type A (MADA) characterized by prominent osteolytic changes and ectodermal defects, associated with a rare homozygous LMNA missense mutation (c.1579C>T).
Case description:
A 6-year-old girl was evaluated during hospitalization exhibiting the following dysmorphic signs: subtotal alopecia, dysmorphic facies with prominent eyes, marked micrognathia and retrognathia, small beaked nose, teeth crowding and thin lips, generalized lipodystrophy, narrow and sloping shoulders, generalized joint stiffness and bone reabsorption in the terminal phalanges. In dermatological examination, atrophic skin, loss of cutaneous elasticity, hyperkeratosis, dermal calcinosis, and hyperpigmented and hypochromic patches were observed. Radiology exams performed showed bilateral absence of the mandibular condyles, clavicle resorption with local amorphous bone mass confluence with the scapulae, shoulder joints with subluxation and severe bone dysplasia, hip dysplasia, osteopenia and subcutaneous calcifications.
Comments:
MADA is a rare autosomal recessive disease caused by mutations in LMNA gene. It is characterized by craniofacial deformities, skeletal anomalies, skin alterations, lipodystrophy in certain regions of the body and premature ageing. Typical MADA is caused by the p.R527H mutation in the LMNA gene. However, molecular analysis performed from oral epithelial cells obtained from the patient showed the rare mutation c.1579C>T, p. R527C in the exon 9 of LMNA. This is the sixth family identified with this mutation described in the literature.
|
{
"authors": [
"Maha El Barch",
"Sandra Davar",
"Annie Bélisle"
],
"case_amount": 1,
"doi": "10.1177/2050313X231212991",
"journal": "SAGE Open Med Case Rep",
"journal_detail": "2023 Nov 16:11:2050313X231212991.",
"keywords": [
"bullous pemphigoid",
"auto-immune bullous disease",
"radiotherapy"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/38022852/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10656799",
"pmid": "38022852",
"title": "A case of radiotherapy-induced bullous pemphigoid with unusually delayed onset: A case report",
"year": "2023"
}
|
PMC10656799
|
Bullous pemphigoid is an auto-immune blistering disease that generally affects older patients. Radiotherapy is one of the many triggering factors that have been described. Time to disease onset is variable; cases have been described during the course of radiotherapy while others have occurred up to 9 years later. We report a case of localized bullous pemphigoid on an irradiated site with unusual late presentation, 25 years after radiotherapy for left breast cancer. The pathophysiology of radiation-induced bullous pemphigoid is not clear, but the concept of an immunocompromised district seems to be a plausible explanation for the delayed onset of the disease.
|
{
"authors": [
"Mingzhu Chen",
"Zhou Hong",
"Haicun Shi",
"Chunmei Wen",
"Yuan Shen"
],
"case_amount": 1,
"doi": "10.3389/fneur.2024.1360222",
"journal": "Front Neurol",
"journal_detail": "2024 Jul 17:15:1360222.",
"keywords": [
"hashimoto’s thyroiditis",
"anti-gad antibodies",
"autoimmune diseases",
"paraneoplastic syndromes",
"stiff-person syndrome"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/39087011/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC11290337",
"pmid": "39087011",
"title": "Stiff-person syndrome in association with Hashimoto's thyroiditis: a case report",
"year": "2024"
}
|
PMC11290337
|
Stiff-person syndrome (SPS) is a rare neurological disorder characterized by chronic and progressive axial muscle rigidity and paroxysmal painful muscle spasms. The present case study described an SPS patient (increased anti-GAD65 antibody in serum and cerebrospinal fluid) with co-occurring Hashimoto's thyroiditis and decreased C3 complement levels. The clinical presentation, diagnostic approach, and treatment employed for this unique case were comprehensively described in detail. In this case, we comprehensively presented a case of SPS with co-occurring Hashimoto's thyroiditis and an associated decrease in serum C3 complement, as well as a discussion on the current data on this topic.
|
{
"authors": [
"Angela Maria Cordoba-Hurtado",
"Laura Fuentes-Mendez",
"Lucia Monserrat Perez-Navarro",
"Virgilia Soto-Abraham",
"Rafael Valdez-Ortiz"
],
"case_amount": 1,
"doi": "10.1159/000537873",
"journal": "Case Rep Nephrol Dial",
"journal_detail": "2024 Mar 22;14(1):48-55.",
"keywords": [
"anca vasculitis",
"case report",
"diffuse systemic sclerosis",
"glomerulopathies",
"overlap syndrome",
"sjögren syndrome"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/38524730/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10959543",
"pmid": "38524730",
"title": "Overlap Syndrome of Diffuse Systemic Sclerosis, Sjögren Syndrome, and ANCA-Associated Renal-Limited Vasculitis: Three Entities in One Patient - Case Report",
"year": "2024"
}
|
PMC10959543
|
Introduction:
The presence of three different entities in a single patient is usually of clinical interest and mostly anecdotal. The overlap of systemic sclerosis (SSc), Sjögren syndrome (SS), and ANCA-associated renal-limited vasculitis has been reported only once previously.
Case presentation:
A 61-year-old female was evaluated at consultation with 2 years of symptomatology, presenting cardboard-like skin, sclerodactyly, limited oral opening, and dry skin and eyes. She was admitted for progressive renal failure (serum creatinine, 5.5 mg/dL). Her serology work-up showed positive anti-SCL-70, anti-Ro, anti-La, anti-MPO, and antinuclear antibodies. Renal biopsy was performed and confirmed histological findings for SSc, SS, and ANCA-associated vasculitis with active extracapillary glomerulonephritis with fibrous predominance (EUVAS-Berden sclerotic class), active tubulointerstitial nephritis, focal tubular injury, and moderate chronic arteriolopathy. Treatment with 6 monthly doses of methylprednisolone and cyclophosphamide was established. At the last follow-up, the patient maintained a stable serum creatinine level of 2.6 mg/dL and had decreased proteinuria, no erythrocyturia, and no requirement for renal replacement therapy.
Conclusion:
Systemic sclerosis is a rare autoimmune disease; nevertheless, overlap with Sjögren syndrome is relatively common, although its association with ANCA vasculitis is anecdotal. Diagnostic integration presents a challenge for nephrologists to define the prognosis and a specific treatment.
|
{
"authors": [
"Lijun Zhou",
"Xinyu Qi",
"Guiying Guo",
"Yanling Wang",
"Jianjun Yang",
"Dingbin Yang",
"Shuqiong Huang"
],
"case_amount": 1,
"doi": "10.2147/CCID.S422290",
"journal": "Clin Cosmet Investig Dermatol",
"journal_detail": "2023 Sep 6:16:2437-2441.",
"keywords": [
"a case report",
"infection",
"infection of purpureocillium lilacinus",
"superficial venipuncture"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/37701060/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10493128",
"pmid": "37701060",
"title": "Cutaneous hyphomycosis Caused by Purpureocillium lilacinus Infection Associated with Superficial Venipuncture: A Case Report",
"year": "2023"
}
|
PMC10493128
|
Cutaneous hyphomycosis caused by Purpureocillium lilacinus is a relatively uncommon event in patients, but there has been a gradual increase in reported cases. A 71-year-old female patient was hospitalized in May 2022 due to an acute episode of chronic obstructive pulmonary disease and received glucocorticoid infusion. The skin around the puncture point on the back of her right hand showed erythema, nodules, scabs, and pus discharge, which gradually worsened. Fungal examination revealed the presence of hyphae, while treatment with terbinafine was ineffective. After fungal culture, pathological analysis, and molecular biology identification techniques, this case was diagnosed as cutaneous and subcutaneous infections caused by Purpureocillium lilacinus. After 2 weeks of treatment with itraconazole, the patient recovered. Patients on long-term hormone preparations who undergo superficial venipuncture should be aware of the risk of skin damage and potential infection by Purpureocillium lilacinus. Prompt fungal culture, histopathological analysis, and molecular identification are crucial for accurate diagnosis. Antifungal susceptibility testing should be considered for effective treatment.
|
{
"authors": [
"Wei Du",
"Hemei Wang",
"Junmei Shen",
"Xi Qiao",
"Jifang Yao",
"Chao Li"
],
"case_amount": 1,
"doi": "10.3389/fonc.2023.1189500",
"journal": "Front Oncol",
"journal_detail": "2023 Aug 22:13:1189500.",
"keywords": [
"cardiac tamponade",
"gastric cardia cancer",
"immunotherapy",
"neoadjuvant chemotherapy",
"transthoracic gastric resection"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/37675225/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10478204",
"pmid": "37675225",
"title": "Cardiac tamponade, a rare complication of gastric cardia cancer resection after neoadjuvant chemotherapy combined with immunotherapy: a case report and literature review",
"year": "2023"
}
|
PMC10478204
|
Transthoracic cardia resection is a technically well-established surgical procedure. However, acute cardiac tamponade in the early postoperative period is extremely rare. The occurrence is life-threatening to the patient. It also poses a great clinical challenge for perioperative management. To date, few cases of pericardial tamponade have been reported in gastric cancer resection performed after neoadjuvant chemotherapy combined with immunotherapy. We present the case of a 62-year-old woman who received neoadjuvant chemotherapy combined with immunotherapy before surgery, followed by transthoracic surgery. A life-threatening complication, pericardial tamponade, occurred in the early postoperative period. The successful outcome was achieved in through multidisciplinary collaboration.
|
{
"authors": [
"Qibin Liu",
"Xiaoman Zhou",
"Li Yao",
"Feng Xu",
"Penggang Tang",
"Ting Li",
"Di Yang",
"Fang Liu",
"Jian Sheng",
"Yuhui Jiang",
"Xiyong Dai",
"Xianxiang Chen"
],
"case_amount": 1,
"doi": "10.1016/j.idcr.2024.e01953",
"journal": "IDCases",
"journal_detail": "2024 Apr 22:36:e01953.",
"keywords": [
"gauze packing",
"hemostasis",
"infection",
"rifampicin resistance",
"tuberculosis"
],
"license": "CC BY-NC-ND",
"link": "https://pubmed.ncbi.nlm.nih.gov/38707650/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC11067492",
"pmid": "38707650",
"title": "A case report of using gauze packing to treat postoperative chest bleeding after left pneumonectomy for secondary rifampicin-resistant tuberculosis",
"year": "2024"
}
|
PMC11067492
|
One patient with rifampin-resistant tuberculosis underwent emergency left pneumonectomy and thoracic gauze packing for hemoptysis due to recurrent hemoptysis after transcatheter arterial embolization. Vital signs were maintained by mechanical ventilation and medication. Tracheotomy and anti-tuberculosis treatment were performed. After half a year of follow-up, the patient's condition was stable.
|
{
"authors": [
"Govind Pandey",
"Kuldeep Singh",
"Tharuna Chandra"
],
"case_amount": 1,
"doi": "10.1016/j.idcr.2024.e02063",
"journal": "IDCases",
"journal_detail": "2024 Aug 22:37:e02063.",
"keywords": [
"art",
"arthritis",
"hiv",
"nsaids"
],
"license": "CC BY-NC-ND",
"link": "https://pubmed.ncbi.nlm.nih.gov/39281310/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC11399689",
"pmid": "39281310",
"title": "Case report of HIV associated arthritis",
"year": "2024"
}
|
PMC11399689
|
Human immunodeficiency virus (HIV) infection is prevalent worldwide. Children living with HIV/AIDS form a vulnerable subsection and may frequently present with clinical symptoms in the first year of life itself. Besides its well-known signs and symptoms, HIV infection can have a wide spectrum of musculoskeletal manifestations. We report a case of a child with HIV infection with arthritis as a predominant presentation. The patient was anemic (Hb: 2.6 g/dl) and had features suggestive of inflammation, that is, highly elevated C-reactive protein (CRP) (161 mg/l), and erythrocyte sedimentation rate (ESR) (46 mm/h) values, accompanied with leukocytosis (12,100 cells/cu mm) and thrombocytoses (524,000 cells/ku mm). Urine culture showed Enterococcus spp. sensitive to linezolid and nitrofurantoin. A bone marrow aspiration and biopsy was done including culture for bacterial, mycobacterium and fungus. Treatment of arthritis in HIV-infected children can be challenging. It is crucial to recognize the arthritic manifestation of HIV infection in order to avoid delaying diagnosis and starting proper treatment.
|
{
"authors": [
"Ami Kumar",
"Kristen L Matulis",
"Zena A Fadel",
"Alexander S Fanning",
"Christian J Amlang",
"Sheng-Han Kuo"
],
"case_amount": 1,
"doi": "10.5334/tohm.925",
"journal": "Tremor Other Hyperkinet Mov (N Y)",
"journal_detail": "2024 Aug 21:14:42.",
"keywords": [
"dbs",
"caudal zona incerta",
"cerebellar ataxia",
"low-frequency stimulation"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/39184972/",
"major_mesh_terms": [
"Cerebellar Ataxia / physiopathology",
"Cerebellar Ataxia / therapy",
"Deep Brain Stimulation / methods",
"Essential Tremor / physiopathology",
"Essential Tremor / therapy",
"Zona Incerta / physiopathology"
],
"mesh_terms": [
"Cerebellar Ataxia / physiopathology",
"Cerebellar Ataxia / therapy",
"Deep Brain Stimulation / methods",
"Essential Tremor / physiopathology",
"Essential Tremor / therapy",
"Zona Incerta / physiopathology",
"Case Reports",
"Aged",
"Humans",
"Male",
"Tremor / etiology",
"Tremor / physiopathology",
"Tremor / therapy"
],
"pmcid": "PMC11342832",
"pmid": "39184972",
"title": "Effects of Low-Frequency Deep Brain Stimulation in Bilateral Zona Incerta for a Patient With Tremor and Cerebellar Ataxia",
"year": "2024"
}
|
PMC11342832
|
Background:
Whether low-frequency deep brain stimulation (DBS) in the caudal zona incerta (cZi) can improve cerebellar ataxia symptoms remains unexplored.
Case report:
We report a 66-year-old man initially diagnosed with essential tremor and subsequently developed cerebellar ataxia after bilateral cZi DBS implantation. We tested the effects of low-frequency DBS stimulations (sham, 10 Hz, 15 Hz, 30 Hz) on ataxia severity.
Discussion:
Low-frequency cZi DBS improves ataxic speech at 30 Hz, but not at 10 Hz or 15 Hz in this patient. Low-frequency DBS did not improve gait or stance. Therefore, low-frequency stimulation may play a role in treating ataxic speech.
Highlights:
The finding of this case study suggests that bilateral low-frequency DBS at 30 Hz in the caudal zona incerta has the potential to improve ataxic speech but has limited impact on gait and stance. The involvement of zona incerta in speech warrants further investigation.
|
{
"authors": [
"Ángel González-de-la-Flor",
"Guillermo García-Pérez-de-Sevilla"
],
"case_amount": 1,
"doi": "10.3389/fbioe.2024.1385786",
"journal": "Front Bioeng Biotechnol",
"journal_detail": "2024 Aug 8:12:1385786.",
"keywords": [
"muscle",
"rectus femoris",
"rehabilitation",
"soccer",
"strain"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/39175620/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC11338860",
"pmid": "39175620",
"title": "A criteria-based progressive rehabilitation program for rectus femoris strain in a recreational soccer player: a case report",
"year": "2024"
}
|
PMC11338860
|
Introduction: The purpose of this study was to describe the criteria-based progressive rehabilitation program implemented on a recreational soccer player diagnosed with a grade 1 rectus femoris strain. Methods: A 33-year-old male injured the rectus femoris muscle. At the first physical examination, the patient showed significant physical impairment due to important limitations to the active range of motion of the knee flexion and the hip flexor strength. The rehabilitation program consisted of specific training of the rectus femoris, lumbopelvic stabilization, mobility exercises, and running technique exercises, for 6 weeks, which was divided into three phases. Each week, the patient performed four rehabilitation sessions, combined with cross-training (swimming), to maintain his cardiorespiratory capacity. Results: The patient improved functionally and returned to play soccer 6 weeks after the injury without pain. Moreover, the patient passed the criteria of each phase at week 2 for phase 1, at week 4 for phase 2 and at week 6 for phase 3. Conclusion: This case study demonstrates that criteria of progression may control the return to sport timetable for recreational soccer players according to the functional and clinical limitations throughout the entire treatment.
|
{
"authors": [
"Taku Harada",
"Toshiyuki Nakanishi",
"Satoshi Kutsuna",
"Mori Nakai"
],
"case_amount": 1,
"doi": "10.1016/j.idcr.2024.e01975",
"journal": "IDCases",
"journal_detail": "2024 Apr 23:36:e01975.",
"keywords": [
"helicobacter cinaedi infection",
"men who have sex with men",
"peritonsillar abscess"
],
"license": "CC BY-NC-ND",
"link": "https://pubmed.ncbi.nlm.nih.gov/38721054/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC11077015",
"pmid": "38721054",
"title": "Peritonsillar abscess associated with Helicobacter cinaedi bacteremia: A case report",
"year": "2024"
}
|
PMC11077015
|
Helicobacter cinaedi, a gram-negative spiral bacterium, has historically been associated with infections primarily in immunocompromised patients. Recently, however, its potential to cause infections in immunocompetent individuals has been recognized. We report a unique case of a man in his 20 s who reported having sex with men. He presented with symptoms of fever and throat discomfort and was diagnosed with a peritonsillar abscess. While the rapid antigen test for Group A Streptococcus was positive and antibiotics were administered, a puncture fluid from the peritonsillar abscess taken the day after antibiotic treatment revealed the presence of Group C Streptococcus. By the fifth day, the blood culture taken on the first day detected a gram-negative spirochete, which was subsequently identified H. cinaedi. The patient had engaged in oral sex with his male partner, suggesting a potential transmission route. This is significant as H. cinaedi was initially identified from rectal cultures in men who have sex with men (MSM), raising the possibility of pharyngeal transmission through oral sex. In our patient, although H. cinaedi was not isolated from the aspirate of the peritonsillar abscess, its presence in the blood culture and lack of other potential sources of bacteremia make the abscess a likely primary site of infection. This case highlights the importance of considering H. cinaedi as a potential pathogen in immunocompetent patients, particularly in cases of MSM. The potential for H. cinaedi transmission through oral sex and its role in the development of peritonsillar abscesses, a previously unreported association, requires further investigation.
|
{
"authors": [
"Balasingam Balagobi",
"Sreekanthan Gobishangar",
"Jathavani Mariyo Maznet Theepan",
"Kuganathan Priyatharsan",
"Kanagalingam Heerthikan",
"Thangarajah Vaishnavi"
],
"case_amount": 2,
"doi": "10.1016/j.ijscr.2023.109130",
"journal": "Int J Surg Case Rep",
"journal_detail": "2024 Jan:114:109130.",
"keywords": [
"adrenal mass",
"adrenalectomy",
"haematopoietic cell",
"incidentaloma",
"myelolipoma"
],
"license": "CC BY-NC-ND",
"link": "https://pubmed.ncbi.nlm.nih.gov/38086131/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10758857",
"pmid": "38086131",
"title": "Unusual discovery: Incidental diagnosis of adrenal myelolipoma, initially confused with liposarcoma, following bee sting bite, resolving chronic right hypochondrial discomfort - A case report",
"year": "2024"
}
|
PMC10758857
|
Introduction and importance:
Adrenal myelolipomas are uncommon benign tumors of the adrenal gland. It has various other sites of origin.
Case presentation:
A 51-year-old male with elevated serum creatinine and an incidentally discovered adrenal mass underwent right adrenalectomy for an adrenal myelolipoma, a benign tumor with fat and haematopoietic components after bee string bite. As the patient was experiencing right hypochondrial pain surgery was planned. After surgery, he developed a surgical site infection, which was treated with antibiotics, and his wound healed well. Excision biopsy confirmed the non-malignant nature of the tumor.
Clinical discussion:
Adrenal myelolipomas are often unilateral, non-functional, and diagnosed using imaging (CT/MRI). While radiological findings can be specific, inconclusive cases may require biopsy for confirmation. Surgical intervention is reserved for hormonally active, symptomatic, or rapidly growing myelolipomas, particularly if they exceed 5 cm.
Conclusion:
Adrenal myelolipomas are common in adrenal glands, typically diagnosed in midlife with no gender bias. Imaging, especially CT, is effective in detecting fat components. In cases of diagnostic uncertainty, fine needle biopsy is crucial for confirmation, and surgery is considered when tumors are hormonally active, grow substantially, or cause symptoms, highlighting personalized care based on patient and imaging data.
|
{
"authors": [
"Jonathan E Zuckerman",
"Rachana Srivastava"
],
"case_amount": 1,
"doi": "10.1159/000530994",
"journal": "Glomerular Dis",
"journal_detail": "2023 May 16;3(1):126-131.",
"keywords": null,
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/37901703/",
"major_mesh_terms": [],
"mesh_terms": [],
"pmcid": "PMC10601899",
"pmid": "37901703",
"title": "Sporadic Case of Heterozygous X-Linked Alport Syndrome",
"year": "2023"
}
|
PMC10601899
|
Alport syndrome is a genetically and phenotypically heterogeneous disorder that can be transmitted in an X-linked, autosomal recessive, or autosomal dominant fashion and can affect glomerular, cochlear, and ocular basement membranes. The disorder results from mutations in the collagen IV genes COL4A5 (X chromosome), COL4A3, and COL4A4. Alport patients are at lifetime risk for kidney failure, sensorineural deafness, and ocular abnormalities. Males with Alport syndrome typically present with severe phenotype with progression to end-stage kidney disease and/or sensorineural deafness and eye changes. Females generally having less severe presentation and diagnosis of X-linked Alport syndrome are generally not considered. Here, we report a case of a 3-year-old girl with gross hematuria, proteinuria, and chronic kidney disease who was found to have features of Alport syndrome on kidney biopsy and a sporadic heterozygous pathogenic COL4A5 deletion on molecular testing. This case report emphasizes the importance of kidney biopsy and molecular testing in the work up of pediatric patients with hematuria, proteinuria, and/or chronic kidney disease. It is also a poignant illustration that females with heterozygous X-linked COL4A5 mutations are often affected patients. It further illustrates the phenomenon of sporadic occurrence of genetic kidney disease in the absence of family history of kidney disease.
|
{
"authors": [
"Bach Ardalan",
"Alan Livingstone",
"Dido Franceschi",
"Danny Sleeman",
"Jose Azqueta",
"Rosali Gonzalez",
"Jonathan England"
],
"case_amount": 1,
"doi": "10.1159/000539776",
"journal": "Case Rep Oncol",
"journal_detail": "2024 Jul 29;17(1):803-808.",
"keywords": [
"complete response",
"pancreatic adenocarcinoma",
"solitary metastasis"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/39144240/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC11324202",
"pmid": "39144240",
"title": "Metastatic Pancreatic Adenocarcinoma Downstaged to T0N0 with Chemotherapy and Targeted Therapy, Confirmed by Surgical Pathology: A Case Report",
"year": "2024"
}
|
PMC11324202
|
Introduction:
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive human tumor that is typically diagnosed at a later stage when surgery is not possible.
Case presentation:
We report the case of a 62-year-old woman who presented to the emergency department with abdominal pain. Computed tomography (CT) revealed a solitary hepatic lesion and a pancreatic body lesion. The pancreatic body lesion was biopsied endoscopically, and a tissue diagnosis was obtained to confirm the diagnosis of PDAC. She was then treated with 12 cycles of FOLFIRINOX with stable disease on CT. Due to the history of a hepatic lesion, she received 11 cycles of gemcitabine/Abraxane and a combination of a MEK inhibitor, Mekinist, and a BRAF inhibitor, BRAFTOVI. Subsequently, the patient underwent a liver biopsy. The biopsy result was negative, and the tumor was deemed resectable. The patient underwent a distal pancreatectomy. Surgical pathology demonstrated a 1.1-cm low-grade papillary mucinous neoplasm with negative margins and lymph nodes, staged T0N0. Adjuvant chemotherapy was not administered.
Conclusion:
To our knowledge, this is the first report of a patient with metastatic pancreatic adenocarcinoma who received prolonged IV and oral chemotherapy. At the time of the operation, the pathological stage was T0N0. The patient has recently been seen 9 months after surgery with no evidence cancer recurrence. Additionally, ctDNA remains negative.
|
{
"authors": [
"Chacko J Joseph",
"Arijit Lodha",
"Soumya R Thomas",
"Essa Al Awad",
"Nicola A M Wright",
"Cora Constantinescu",
"Doan Le",
"Majeeda Kamaluddeen"
],
"case_amount": 3,
"doi": "10.3389/fped.2023.1247343",
"journal": "Front Pediatr",
"journal_detail": "2023 Sep 21:11:1247343.",
"keywords": [
"chylothorax",
"congenital",
"newborn",
"pleural effusion",
"purpura fulminans"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/37808560/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10552855",
"pmid": "37808560",
"title": "Case report: Blotchy skin in a puffy neonate: is there a new association?",
"year": "2023"
}
|
PMC10552855
|
Introduction:
Purpura fulminans in the neonatal population is a rare but potentially life-threatening condition complicated by thrombosis, resultant vital organ necrosis, and gangrene of the extremities. Considering the rapid evolution of the pathogenetic mechanism, an index of suspicion, early identification, and prompt intervention are imperative for improved outcomes. The majority of purpura fulminans cases have an infectious etiology, but it is essential to consider other congenital and acquired causes.
Case description:
We present a clinical case of a female neonate to emphasize the correlation between purpura fulminans, congenital chylothorax, involvement of the PAK2 gene, and the occurrence of retinal detachment in both eyes. After draining the congenital chylothorax, the neonate developed purpura fulminans due to a loss of protein C, S, and antithrombin factors, previously not reported in the literature. The purpuric lesions resolved after the administration of fresh frozen plasma. Subsequently, no recurring purpura fulminans lesions were noted following the normalization of the antithrombotic factor levels in the serum. Subsequently, the child also developed retinal detachment in both eyes.
|
{
"authors": [
"Homa Pourriyahi",
"Homayoun Pourriahi",
"Hossein Najd Sepas"
],
"case_amount": 6,
"doi": "10.1016/j.ejvsvf.2024.05.002",
"journal": "EJVES Vasc Forum",
"journal_detail": "2024 May 10:61:126-131.",
"keywords": [
"aneurysm",
"aneurysmoplasty",
"aneurysmorrhaphy",
"arteriovenous fistula",
"megafistula",
"partial aneurysmectomy"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/38884071/",
"major_mesh_terms": [],
"mesh_terms": [],
"pmcid": "PMC11177082",
"pmid": "38884071",
"title": "Salvage Aneurysmorrhaphy as an Adaptable and Still Pertinent Technique in the Management of Challenging True Aneurysms of Arteriovenous Fistulas: A Case Series of Different Variations, With Illustrative Surgical Pictures",
"year": "2024"
}
|
PMC11177082
|
Introduction:
Aneurysmorrhaphy, described as reduction aneurysmoplasty, partial aneurysmectomy, or vessel wall recalibration, can be considered a suitable surgical plan for true aneurysms of arteriovenous fistulas (AVFs), allowing for a dynamic approach to reconstruction of aneurysmal AVFs of different severities, ensuring salvage of the native access.
Report:
Six challenging cases of AVF aneurysms are presented, some with extremely dilated and tortuous megafistulas, for which three surgical technique variations were performed. The patients had a mean age of 59.2 years, 50% were female, with brachiocephalic (n = 5, 83.3%) or brachiobasilic (n = 1, 16.7%) AVFs. The fistulas were created an average of 4.67 years previously, and the aneurysms had an average maximum diameter of 37.5 mm (range 25-60 mm). Surgical indications were rupture risk, thrombosis, or outflow stenosis compromising haemodialysis, infections, and concerns for quality of life (affected by post-puncture bleedings, disfiguring aesthetics, pain, and discomfort). The surgical techniques were simple aneurysmorrhaphy (n = 3, 50%), aneurysmorrhaphy with partial excision of aneurysmal segment with end to end anastomosis of venous ends (n = 2, 33.3%), and aneurysmorrhaphy with establishment of new venous outflow (n = 1, 16.7%). All AVFs were patent post-operatively and at follow up (mean 5.6 months, median one month). Haemodialysis was resumed through the AVFs at a mean of 2.17 weeks post-operatively, with placement of an alternative route for haemodialysis in the meantime. No patients experienced post-operative complications.
Discussion:
Experience with the more challenging cases shows that aneurysmorrhaphy can still be considered an acceptable, flexible, and pertinent method for salvage of megafistulas, giving the surgeon the much needed versatility to adapt to anatomical and pathological variations, with high patency rates and minimal complications, especially when other treatment options are not possible in complicated cases. AVF salvage through aneurysmorrhaphy allows for a dynamic approach to the reconstruction of severely tortuous, dilated veins, ensuring patency of the native AVF.
|
{
"authors": [
"Ethan Meijer",
"Henk van den Berg",
"Arjen H G Cleven",
"Esther Edelenbos",
"Willem H Schreuder"
],
"case_amount": 1,
"doi": "10.1155/2023/2347855",
"journal": "Case Rep Dent",
"journal_detail": "2023 Nov 9:2023:2347855.",
"keywords": null,
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/38020961/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10653967",
"pmid": "38020961",
"title": "Treatment of Progressive Cherubism during the Second Dental Transitional Phase with Calcitonin",
"year": "2023"
}
|
PMC10653967
|
Cherubism is an autosomal dominant disease with variable expression. Aggressive forms of untreated cherubism may lead to severe malformation of the maxillofacial skeleton, developing tooth germs and teeth. Scarcely described and empirically applied interventional therapies during active stages of the disease try to limit the damage and deformation caused by progression of expanding intraosseous lesions. The final goal is to minimize the need for corrective surgeries once progressive growth has halted and disease enters its quiescent phase. New insights into the pathophysiology of cherubism hypothesize a potential role for dental development and jaw growth in the (hyper)activation of the disease. Theoretically, this could guide the ideal moment of pharmacological interventions. In this case report, the off-label use of systemic calcitonin treatment is described, stressing particularly the potential importance of its appropriate timing and duration of treatment.
|
{
"authors": [
"Hiroyuki Yamamoto",
"Nao Kume",
"Katsuya Hashimoto",
"Jun Isogai",
"Takuya Kuwabara",
"Masayuki Noguchi",
"Hiroyuki Murayama",
"Toru Hashimoto",
"Hidemitsu Ogino"
],
"case_amount": 1,
"doi": "10.3389/fcvm.2023.1329952",
"journal": "Front Cardiovasc Med",
"journal_detail": "2024 Jan 9:10:1329952.",
"keywords": [
"covid-19",
"acute pericarditis",
"cytology",
"hemorrhagic pericardial tamponade",
"sarcoid-like reaction"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/38264260/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10803410",
"pmid": "38264260",
"title": "Subacute hemorrhagic pericardial tamponade after COVID-19 infection mimicking carcinomatous pericarditis: a case report",
"year": "2024"
}
|
PMC10803410
|
Background:
Coronavirus disease (COVID-19)-associated acute pericarditis has recently received much attention owing to its high frequency associated with pericardial tamponade (PT), showing unfavorable prognosis. However, early diagnosis and treatment remain challenging in cases of non-specific signs and symptoms.
Case presentation:
A 64-year-old man was admitted to our hospital for acute osteomyelitis of the toes and was properly treated with antimicrobial agents. Three days after admission, the patient developed mild COVID-19 without pneumonia, for which early anti-COVID-19 agents were initiated. Nevertheless, the patient developed hemorrhagic PT due to acute pericarditis 2 weeks later, which was confirmed by cardiac magnetic resonance, requiring an urgent pericardiocentesis. Although cytological analysis of the hemorrhagic pericardial fluid strongly suggested adenocarcinoma, the atypical cells were eventually proven to be mesothelial cells with reactive atypia. Furthermore, lymph nodes swelling with abnormal 2-[18F]-fluoro-2-deoxy-D-glucose accumulation on imaging were suggestive of malignancy. However, biopsy examination revealed multiple non-caseating granulomas in the lymph node, unlikely due to malignancy. Eventually, the temporal association of the preceding COVID-19 with the occurrence of subacute PT without other identifiable cause led to a final diagnosis of COVID-19-associated acute pericarditis. With anti-inflammatory and corticosteroids treatment, the patient's symptoms involving the pericardial structure and function were completely resolved along with improvements in size of the affected lymphadenopathies.
Conclusions:
We encountered a unique case of COVID-19-associated acute pericarditis exhibiting hemorrhagic PT. This case underscores the residual risk of delayed pericardial involvement even in patients with mild COVID-19 who receive early treatment, and the recognition that COVID-19 may cause various cytomorphological and histological features. Additionally, the importance of considering this rare entity as a cause of hemorrhagic pericardial effusions should be highlighted.
|
{
"authors": [
"Anil Kaplan",
"Taner Akalin",
"Melis Palamar"
],
"case_amount": 3,
"doi": "10.14744/bej.2024.79664",
"journal": "Beyoglu Eye J",
"journal_detail": "2024 Sep 1;9(3):161-164.",
"keywords": [
"cornea",
"eye",
"ocular surface",
"ocular surface squamous neoplasia",
"renal transplant"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/39239627/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC11372405",
"pmid": "39239627",
"title": "Ocular Surface Squamous Neoplasia in Renal Transplant Patients",
"year": "2024"
}
|
PMC11372405
|
Transplantation surgery becomes more widespread with time worldwide; organ transplantation increases the risk of developing malignancies. This phenomenon is primarily due to immunosuppressive treatment which is one of the mainstay approaches to prevent transplant rejection. It is aimed to describe clinical signs and symptoms of histologically proven ocular surface squamous neoplasia (OSSN) in renal transplant patients. Three patients, who previously underwent renal transplant surgery, diagnosed with OSSN are presented. The histopathological examination results were conclusive for squamous cell neoplasia in all cases. No recurrence in any patients was observed after total surgical excision, cryotherapy, and reconstruction with amniotic membrane. Solid organ transplant patients undergo intense immunosuppressive treatment to prevent transplant rejection. That immunosuppressive treatment increases the risk of developing secondary malignancies including OSSN. It is important to inform all transplant patients about these risks. Even though OSSN is known to be a relatively benign acting tumor that rarely metastasizes to distant organs, the clinical course might change if it develops in an immunocompromised patient. For this reason, these patients should be monitored for any formation of a mass on the ocular surface. Surgical management through complete excision can result in the complete resolution of a tumor.
|
{
"authors": [
"Julieta E Rodriguez",
"Damien Vasseur",
"Mohamed Amine Bani",
"Odile Cabaret",
"Sophie Cotteret",
"Martine Muleris",
"Veronica Golbarg",
"David Malka",
"Thomas Pudlarz",
"Olivier Caron",
"Cristina Smolenschi"
],
"case_amount": 1,
"doi": "10.3389/fonc.2024.1396869",
"journal": "Front Oncol",
"journal_detail": "2024 Jun 18:14:1396869.",
"keywords": [
"case report",
"circulating dna",
"colorectal cancer",
"discordant msi",
"next-generation sequencing"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/38957326/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC11217479",
"pmid": "38957326",
"title": "Case report: Microsatellite instability determination is not always black and white in Lynch syndrome diagnosis",
"year": "2024"
}
|
PMC11217479
|
Introduction:
Microsatellite instability (MSI) is a genetic marker that is useful in the detection and treatment of Lynch syndrome (Sd). Although conventional techniques such as immunohistochemistry (IHC) and polymerase chain reaction (PCR) are the standards for MSI detection, the advent of next-generation sequencing (NGS) has offered new possibilities, especially with circulating DNA.
Case report:
We present the case of a 26-year-old patient with Lynch Sd and a BRAF-mutated metastatic colon cancer. The discordant MSI results between the conventional methods and NGS posed challenges in making treatment decisions. Subsequent NGS analysis revealed a high MSI status, leading to participation in an immunotherapy trial, with remarkable clinical response.
Conclusion:
This case emphasizes the importance of comprehensive molecular profiling and strong interdisciplinary collaborations, especially in cases with ambiguous MSI results.
|
{
"authors": [
"Tawfiq Ahmad Mushkani",
"Zabih Ur Rahman Roheen"
],
"case_amount": 1,
"doi": "10.2147/IMCRJ.S453954",
"journal": "Int Med Case Rep J",
"journal_detail": "2024 Mar 12:17:157-160.",
"keywords": [
"bilateral",
"high intraocular pressure",
"iris coloboma"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/38495805/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10944301",
"pmid": "38495805",
"title": "Bilateral Iris Coloboma in an 11-Year-Old Child with Low Vision and High Intraocular Pressure: A Rare Case Report and Review of Literature",
"year": "2024"
}
|
PMC10944301
|
Background:
Coloboma means curtailed in Greek language. It is mainly used when normal tissue of the eye or another organ is not present since birth. Coloboma is a congenital abnormality mainly caused by incomplete closure of the embryonic fissure of the choroid part of eye.
Purpose:
The aim of this case report is to share the clinical findings in a patient with bilateral iris coloboma, low vision, and headache.
Patients and methods:
Case report.
Results:
An eleven-year-old boy with low vision and headache visited the University Eye Hospital of Kabul University of Medical Science (UEHKUMS) for consultation. Ophthalmic examination revealed a bilateral iris coloboma without concomitant chorioretinal defect, refractive error, and high intraocular pressure in both eyes. The refractive error of the patient was corrected by advising proper glasses, and the high intraocular pressure was controlled by anti-glaucoma drops. After several follow-up visits, the patient no longer complained of headache and low vision.
Conclusion:
Visiting patients with iris coloboma should be considered for intraocular pressure (IOP) check, and screening of other family members is mandatory.
|
{
"authors": [
"Lisa Debbarma",
"Vineet Sharma"
],
"case_amount": 4,
"doi": "10.7759/cureus.51933",
"journal": "Cureus",
"journal_detail": "2024 Jan 9;16(1):e51933.",
"keywords": [
"attrition",
"hobo twin-stage",
"patient-centered",
"pfm crowns",
"vertical dimension"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/38333449/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10851815",
"pmid": "38333449",
"title": "Full Mouth Rehabilitation for a Patient With Generalized Attrition: The Hobo Technique in Action",
"year": "2024"
}
|
PMC10851815
|
This case report addresses the critical issue of severe tooth wear and its impact on the vertical dimension of occlusion in a 75-year-old patient. The patient presented with worn-down teeth, chewing difficulties, and aesthetic concerns, prompting a comprehensive treatment plan utilizing the Hobo twin-stage technique. The approach involved careful diagnosis, root canal therapy, and the creation of provisional restorations, monitored through an occlusal splint. The prosthetic phase incorporated strategically designed porcelain-fused-to-metal crowns, aiming for optimal tooth alignment and balanced movement. The successful outcome not only restored function and aesthetics but also enhanced the patient's confidence. This case underscores the effectiveness of a systematic approach in managing severe tooth wear, emphasizing the importance of regular follow-ups and good oral hygiene for long-term success.
|
{
"authors": [
"Jennifer Wolf",
"Nicole Goncalves",
"Ioannis Alagkiozidis"
],
"case_amount": 1,
"doi": "10.3389/fonc.2024.1302724",
"journal": "Front Oncol",
"journal_detail": "2024 Feb 2:14:1302724.",
"keywords": [
"cytoreductive surgery",
"debulking",
"minimally invasive surgery",
"ovarian cancer",
"robotic-assisted surgery"
],
"license": "CC BY",
"link": "https://pubmed.ncbi.nlm.nih.gov/38371627/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10870411",
"pmid": "38371627",
"title": "Case report: Minimally invasive primary debulking surgery for advanced stage epithelial ovarian cancer",
"year": "2024"
}
|
PMC10870411
|
The surgical management of advanced ovarian cancer has historically emphasized an open technique, but advances in minimally invasive surgery (MIS) have led to its increasing use in ovarian cancer. Most research has focused on the utility of MIS in the interval debulking setting. Here, we present a case of a 38-year-old patient with incidentally diagnosed advanced stage ovarian cancer. We describe the robotic surgery techniques used to achieve complete primary cytoreduction, including resection of disease on the diaphragm. The patient has completed standard adjuvant chemotherapy and maintenance treatment and remains without evidence of disease for more than 2 years. This case details the techniques utilized to achieve complete cytoreduction including trocar placement, robotic instrument preference, and rotation of the robotic boom. This patient has had successful perioperative and oncologic outcomes, and her case highlights the role for minimally invasive primary debulking surgery for select patients with advanced ovarian cancer.
|
{
"authors": [
"Ashutosh Kashyap",
"Laxmi Raj Bhatta",
"Bhuwan Bhatta",
"Prakash Nepali",
"Pratigya Gyawali",
"Ashik Rajak",
"Sarita Dhakal"
],
"case_amount": 1,
"doi": "10.1177/2050313X231225342",
"journal": "SAGE Open Med Case Rep",
"journal_detail": "2024 Jan 9:12:2050313X231225342.",
"keywords": [
"dengue",
"stemi",
"case report",
"myocarditis"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/38205141/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10777758",
"pmid": "38205141",
"title": "Dengue fever complicated with ST elevation myocardial infarction with atypical features: A case report",
"year": "2024"
}
|
PMC10777758
|
Dengue fever is an arboviral infection whose presentation ranges from a mild febrile illness to a multisystem complicated syndrome. We report a case of 58-year-old female presenting with fever, myalgia, arthralgia, and vomiting who was found to be infected with dengue and had electrocardiography changes revealing ST-segment elevation myocardial infarction, a rare manifestation in dengue. Dengue fever can affect the cardiovascular system leading to conduction abnormalities, hypotension, arrhythmias, myocarditis, cardiomyopathy, and occasionally myocardial infarction, which has been reported in only a few case reports prior to this. The differentiation between myocarditis and myocardial infarction is essential for which echocardiography and coronary angiography can be helpful. It is essential to keep an eye on the cardiovascular complications in a dengue patient as the presentation can be quite subtle with devastating consequences.
|
{
"authors": [
"Merga Daba Mulisa",
"Shalom Kassahun Bekele",
"Sebhatleab Teju Mulate",
"Zerubabel Getahun Kiflu",
"Yared Getachew Tadesse",
"Walelign Worku Mamo"
],
"case_amount": 1,
"doi": "10.2147/IMCRJ.S455329",
"journal": "Int Med Case Rep J",
"journal_detail": "2024 May 15:17:455-458.",
"keywords": [
"extremity weakness",
"flaccid paralysis",
"hypermagnesemia"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/38765867/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC11102740",
"pmid": "38765867",
"title": "Hypermagnesemia Complicated by Acute Flaccid Paralysis, Case Report",
"year": "2024"
}
|
PMC11102740
|
Hypermagnesemia is a rare electrolyte abnormality observed in the clinical setting. Patients with this condition can present with a variety of symptoms, depending on the level of serum magnesium. Hypermagnesemia is rarely complicated by weakness of the extremities. We report the case of 32 years old female patient who presented with bilateral upper- and lower-extremity weakness due to hypermagnesemia. Following correction of the serum magnesium level, extremity weakness subsided, and the patient was discharged with improvement. Here, we discuss the delay in the diagnosis and management of this type of clinical presentation.
|
{
"authors": [
"Atieh Akbari",
"Parisa Behravan",
"Afshin Moradi",
"Mohammad Esmaeil Akbari"
],
"case_amount": 1,
"doi": "10.1159/000538771",
"journal": "Case Rep Oncol",
"journal_detail": "2024 Jun 3;17(1):608-613.",
"keywords": [
"breast",
"granular cell tumor",
"schwann cells",
"uncommon tumors"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/39015632/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC11250677",
"pmid": "39015632",
"title": "Case Report of a Benign Granular Cell Tumor Resembling Breast Carcinoma in a Young Woman: A Diagnostic Challenge",
"year": "2024"
}
|
PMC11250677
|
Introduction:
Granular cell tumors (GCTs) are uncommon, low-grade Schwann cell tumors found in the skin, soft tissue, and mucosal surfaces of the oral, gastrointestinal, and respiratory tracts. One in 1,000 breast cancer cases is GCT. Just 1-2% of GCTs are malignant GCTs.
Case presentation:
This case report presents the clinical details and outcomes of a 34-year-old woman with a main concern of a palpable mass and pain in her right breast. In the clinical examination, we found a 1.5 × 2-cm palpable mass in her right breast with no axillary lymph node detection. The primary diagnosis was a benign GCT mimicking carcinoma of the breast. Upon evaluation, the mass was confirmed to be a benign GCT through pathology. The patient underwent breast-conserving surgery and sentinel lymph node dissection at the Cancer Research Center of Shahid Beheshti University of Medical Sciences on November 30, 2022. The surgical margins were found to be free of tumors, and there was no involvement of skin or axillary lymph nodes. The patient had a positive postoperative outcome, with no complications observed.
Conclusion:
The case highlights the importance of accurate diagnosis and appropriate surgical planning to avoid invasive procedures and unnecessary radical surgeries in cases of benign GCT mimicking carcinoma of the breast.
|
{
"authors": [
"Fengqin Zhu",
"Zongjing Hu",
"Wei Yu",
"Fengxian Dai",
"Dehuai Jing",
"Guangxi Zhou"
],
"case_amount": 1,
"doi": "10.2147/JIR.S422057",
"journal": "J Inflamm Res",
"journal_detail": "2023 Aug 28:16:3715-3723.",
"keywords": [
"acute myeloid leukemia",
"bullous sweet’s syndrome",
"cytomegalovirus",
"ulcerative colitis"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/37663756/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10473406",
"pmid": "37663756",
"title": "Ulcerative Colitis Concomitant with Cytomegalovirus Infection, Bullous Sweet's Syndrome, and Acute Myeloid Leukemia: A Case Report and Literature Review",
"year": "2023"
}
|
PMC10473406
|
Background:
Ulcerative colitis (UC) is a chronic, relapsing progressive inflammatory immune disease. There is still no cure for it. Even worse, UC may predispose patients to opportunistic infections, and several extra-intestinal manifestations (EIMs) and comorbidities may antedate, occur with, or postdate the onset of UC, which may increase the mortality risk. But case reports of UC patients simultaneously concomitant with opportunistic infection, EIM, and comorbidity are extremely rare.
Case presentation:
We report a case of 51-year-old male patient with incipient UC accompanied by cytomegalovirus (CMV) infection and bullous Sweet's syndrome (bSS, a cutaneous EIM of UC) after treatment with oral mesalazine and prednisolone for 3 weeks. After clearance of the CMV infection by using ganciclovir, the patient was administered two cycles of infliximab to cure UC and bSS; however, he developed acute myeloid leukemia (AML) a month later and died after two cycles of chemotherapy.
Conclusion:
Based on this rare case of UC concomitant with CMV infection, bSS and AML, we recommend that it is important to distinguish between an acute UC flare and opportunistic infections, especially in patients receiving immunosuppressive therapy, and monitor EIMs and comorbidities timely. Particular attention should be paid to cancer surveillance. Clinicians should be mindful of these facts to adopt optimal therapeutic options to address all aspects of UC. Early initiation of biological therapy may be of benefit to patients with newly diagnosed severe UC.
|
{
"authors": [
"Hiroaki Oiwa",
"Kosuke Sugawara",
"Sho Morita",
"Asuka Uebayashi",
"Hiroaki Sakai",
"Kazuhito Funai",
"Toshinari Ema"
],
"case_amount": 1,
"doi": "10.21037/acr-23-92",
"journal": "AME Case Rep",
"journal_detail": "2023 Dec 13:8:14.",
"keywords": [
"subglottic stenosis",
"case report",
"double‑lumen tube (dlt)",
"thoracic surgery"
],
"license": "CC BY-NC-ND",
"link": "https://pubmed.ncbi.nlm.nih.gov/38234353/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10789894",
"pmid": "38234353",
"title": "Severe subglottic stenosis after resection of anterior mediastinal tumor using a double‑lumen tube: a case report",
"year": "2023"
}
|
PMC10789894
|
Background:
Double‑lumen tubes (DLTs) are commonly used for differential pulmonary ventilation during thoracic surgery. Few reports exist on subglottic stenosis among patients who underwent surgery involving DLTs; we lack immediate postoperative period documentation leading up to the onset and subsequent recovery of subglottic stenosis. Herein, we present a case of a 75-year-old woman successfully treated for subglottic stenosis after DLT.
Case description:
A 75-year-old woman presented to our hospital with an abnormal chest shadow, which was identified during a medical examination. Chest computed tomography revealed an anterior mediastinal mass with a poor contrast effect measuring 6.0 cm × 3.1 cm × 1.9 cm, which grew from 2.2 to 6.0 cm over 21 months. Low and high signals were detected on T1- and T2-weighted thoracic magnetic resonance imaging, respectively. Concordantly, a thymic cyst was suspected. The patient underwent robotic-assisted thoracoscopic resection via the right lateral approach. A 35-Fr left-sided DLT was used for intubation and differential lung ventilation. Hoarseness and stridor were observed on postoperative day (POD) 1. Laryngoscopy showed submucosal hemorrhage around the vocal cords and mild subglottic stenosis; however, there was no arytenoid dislocation or findings necessitating emergency treatment. On POD 4, her stridor became more severe and laryngoscopy was re-performed and revealed subglottic stenosis progression prompting emergency tracheotomy. The stenosis further progressed, and almost complete airway obstruction was observed on POD 7. By POD 9, partially improving the subglottic stenosis, thereafter the subglottic stenosis was almost completely alleviated by POD 12. The tracheal cannula was removed on POD 22. Trachea-cutaneous fistula closure was performed on POD 35, and she was discharged on POD 42, remaining well. The pathological examination of the anterior mediastinal tumor confirmed the diagnosis of thymic cyst.
Conclusions:
Airway obstruction owing to subglottic stenosis may occur several days post-surgery with a DLT. Prompt tracheostomy is recommended to prevent complete airway obstruction in patients with progressive subglottic stenosis.
|
{
"authors": [
"Connor Skoumal",
"Matt Dewald"
],
"case_amount": 1,
"doi": "10.26603/001c.91642",
"journal": "Int J Sports Phys Ther",
"journal_detail": "2024 Feb 1;19(2):238-244.",
"keywords": [
"case report",
"pitching",
"scapular dyskinesis",
"softball"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/38313669/",
"major_mesh_terms": [],
"mesh_terms": [],
"pmcid": "PMC10837815",
"pmid": "38313669",
"title": "Clinical Diagnosis of Scapular Dyskinesis in a Youth Softball Pitcher: A Case Report",
"year": "2024"
}
|
PMC10837815
|
Introduction:
Effective rehabilitation strategies for upper extremity injuries in softball pitchers are scarce in current literature, especially among youth athletes. Additionally, there continues to be ambiguity regarding the interpretation and clinical practicality when treating an overhead athlete with scapular dyskinesis. The purpose of this case report is to highlight the examination and treatment of a youth softball pitcher referred to physical therapy with the diagnosis of scapular dyskinesis.
Case description:
This case report presents data and outcomes for a 14-year-old female who experienced chronic right shoulder discomfort related to performing the windmill softball pitch (WSP). The subject was clinically diagnosed with scapular dyskinesis by her referring physician and demonstrated abnormal scapular movement when elevating and lowering her upper extremity. Internal and external rotator isokinetic strength testing and the Athletic Shoulder Test (ASH) were used as primary objective measures. Both were performed six days after the initial evaluation and again six weeks later. Initial testing demonstrated decreased peak torque and total work. Initial treatment involved periscapular and shoulder strengthening with progression to overhead loading. Later rehabilitation strategies focused on neuromuscular control, functional training, and sport-specific activities.
Outcomes:
The subject initially demonstrated improved peak torque and total work of the shoulder with isokinetic strength testing but continued to have symptoms with pitching, even though the Scapular Dyskinesis Test had become negative. After changing the focus to neuromuscular and functional training the subject had fewer symptoms and became comfortable with self-management.
Discussion:
This case matches previous research that endorses scapular dyskinesis being a normal finding in overhead athletes with and without shoulder pain. Neuromuscular control and functional training after a period of scapular strengthening were beneficial in improving symptoms in this athlete.
Level of evidence:
5.
|
{
"authors": [
"Olivia Julian",
"Kailyn Wilcox",
"Davek Sharma",
"Kathleen Lamb",
"Robert Luo",
"Hong Zheng",
"Renganaden Sooppan",
"Amir Behnam"
],
"case_amount": 2,
"doi": "10.1093/jscr/rjad306",
"journal": "J Surg Case Rep",
"journal_detail": "2024 Jan 16;2024(1):rjad306.",
"keywords": [
"groin wound coverage",
"groin wounds",
"lower extremity reconstruction",
"rectus femoris muscle flap",
"revascularization"
],
"license": "CC BY-NC",
"link": "https://pubmed.ncbi.nlm.nih.gov/38239382/",
"major_mesh_terms": [],
"mesh_terms": [
"Case Reports"
],
"pmcid": "PMC10795896",
"pmid": "38239382",
"title": "Viability of the rectus femoris muscle flap for groin wound coverage after ligation of proximal inflow",
"year": "2024"
}
|
PMC10795896
|
Lower extremity revascularization via groin incisions can be complicated by wound dehiscence associated with infection, seroma and femoral vessel exposure. This may require additional surgical debridement and coverage of vascular structures and grafts. The pedicled rectus femoris muscle flap (RFF) has both bulk and a large arc of rotation, making it useful for reconstruction. Its main pedicle is the descending branch of the lateral femoral circumflex artery (DLFCA), a branch of the profunda femoris artery. One could anticipate that ligation of more proximal vasculature could lead to ischemia of the RFF. We present two patients who each underwent vascular surgery involving the common femoral artery and subsequent reconstruction utilizing a pedicled RFF. Both patients then required additional vascular procedures involving the ligation of inflow vessels proximal to the DLFCA. The flaps remained viable, demonstrating the rich collateralization of blood supply that occurs in vascular disease patients.
|
Subsets and Splits
Thyroid Articles Abstracts
Retrieves articles with 'thyroid' in the abstract, providing basic information about each article but limited analytical value.